Bio-valorization of Tagetes floral waste extract in fabrication of self-healing Schiff-base nanocomposite hydrogels for colon cancer remedy.

The drastic boom in floriculture and social events in religious and recreational places has inevitably led to generation of tremendous floral waste across the globe. Marigold (Tagetes erecta) is one of the most common loose flowers offered for the same. Generally discarded, these Tagetes floral wastes could be valorized for biogenic syntheses. In this study, we have utilized the floral extract towards green synthesis of nano ZnO, the formation of which was affirmed from different analytical techniques. Bionanocomposite Schiff-base hydrogel composed of chitosan and dialdehyde pectin was fabricated by the facile strategy of in situ polymer cross-linking, and the ZnO nanoparticles were embedded in the hydrogel matrix. The hydrogel exhibited remarkable self-healing ability. The antioxidant and anti-inflammatory activities were enhanced owing to nano ZnO. Furthermore, it was hemocompatible and biodegradable. A controlled release drug profile for 5-fluorouracil from the hydrogel was accomplished in the colorectum. The exposure of the drug-loaded nanocomposite hydrogel demonstrated improved anticancer effects in HT-29 colon cancer cells. The findings of this study altogether put forth the successful biovalorization of Tagetes floral waste extract for colon cancer remedy.