We have located links that may give you full text access.
Journal Article
Review
Biomarker Enrichment in Sepsis Associated Acute Kidney Injury: Finding High-Risk Patients in the ICU.
American Journal of Nephrology 2023 October 17
Abstract: Background: Sepsis associated Acute kidney injury (AKI) is a leading comorbidity in admissions to the intensive care unit. While a gold standard definition exists, it remains imperfect and does not allow for the timely identification of patients in the setting of critical illness. This review will discuss the use of biochemical and electronic biomarkers to allow for prognostic and predictive enrichment of patients with sepsis associated AKI over and above the use of serum creatinine and urine output. Summary: Current data suggest that several biomarkers are capable of identifying patients with sepsis at risk for the development of severe AKI and other associated morbidity. This review discusses this data and these biomarkers in the setting of sub-phenotyping and endotyping sepsis associated AKI. While not all of these tests are widely available and some require further validation, in the near future we anticipate several new tools to help nephrologists and other providers better care for patients with sepsis associated AKI. Key messages: Predictive and prognostic enrichment using both traditional biomarkers and novel biomarkers in the setting of sepsis can identify subsets of patients with either similar outcomes or similar pathophysiology respectively. Novel biomarkers can identify kidney injury in patients without consensus definition AKI (e.g. changes in creatinine or urine output); and can predict other adverse outcomes (e.g. severe consensus definition AKI, inpatient mortality). Finally, emerging artificial intelligence and machine learning derived risk models are able to predict sepsis associated AKI in critically ill patients using advanced learning techniques and several laboratory and vital sign measurements.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app