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American Journal of Nephrology

Jessica Fitzpatrick, Stephen M Sozio, Bernard G Jaar, Mara A McAdams-DeMarco, Michelle M Estrella, Larisa G Tereshchenko, Jose M Monroy-Trujillo, Rulan S Parekh
BACKGROUND: The risk of cardiovascular mortality is high among adults with end-stage renal disease (ESRD) undergoing hemodialysis. Waist-to-hip ratio (WHR), a metric of abdominal adiposity, is a predictor of cardiovascular disease (CVD) and mortality in the general population; however, no studies have examined the association with CVD mortality, particularly sudden cardiac death (SCD), in incident hemodialysis. METHODS: Among 379 participants incident (< 6 months) to hemodialysis enrolled in the Predictors of Arrhythmic and Cardiovascular Risk in ESRD study, we evaluated associations between WHR and risk of CVD mortality, SCD, and non-CVD mortality in Cox proportional hazards regression models...
November 14, 2018: American Journal of Nephrology
Tarra Faulk, Lauren E Walker, Jeffrey T Howard, Jud C Janak, Jonathan A Sosnov, Ian J Stewart
BACKGROUND: Although rhabdomyolysis has been associated with acute kidney injury and mortality in the short term, the long-term consequences of an episode of rhabdomyolysis remain unknown. We sought to identify the long-term outcomes of rhabdomyolysis, including mortality, renal function, and incidence of hypertension (HTN), among service members initially admitted to the intensive care unit after sustaining a combat injury in Iraq or Afghanistan between February 1, 2002 and February 1, 2011...
November 14, 2018: American Journal of Nephrology
Gang Jee Ko, Yoshitsugu Obi, Melissa Soohoo, Tae Ik Chang, Soo Jeong Choi, Csaba P Kovesdy, Elani Streja, Connie M Rhee, Kamyar Kalantar-Zadeh
BACKGROUND: The population of elderly end-stage renal disease patients initiating dialysis is rapidly growing. Although longer treatment is supposed to benefit for hemodialysis (HD) patients through more solute clearance and slower fluid removal, it is not yet clear how treatment session length affects mortality risk in octogenarians and nonagenarians. METHODS: In a cohort of 112,026 incident HD patients between 2007 and 2011, we examined the association of treatment session length with all-cause mortality, adjusting for demographics and comorbid conditions...
November 13, 2018: American Journal of Nephrology
Jing Liu, Wei Zhu, Chun-Ming Jiang, Yuan Feng, Yang-Yang Xia, Qing-Yan Zhang, Peng-Fei Xu, Miao Zhang
Peritoneal fibrosis (PF) is characterized by progressive extracellular matrix (ECM) accumulation. Increasing evidence has suggested that ECM synthesis was increased in human peritoneal mesothelial cells (HPMCs) under high-glucose conditions, but the effects of high-glucose peritoneal dialysis solution (PDS) on ECM synthesis have not been fully elucidated. The aim of this study was to explore the potential mechanisms of high-glucose PDS-induced production of ECM in HPMCs. HPMCs were stimulated by high-glucose PDS...
November 13, 2018: American Journal of Nephrology
Mary Hammes, George L Bakris
No abstract text is available yet for this article.
November 13, 2018: American Journal of Nephrology
Steven M Brunelli, Dena E Cohen, Gilbert Marlowe, David Van Wyck
BACKGROUND: Intradialytic hypotension (IDH) is a frequent complication of hemodialysis, and is associated with significant morbidity and mortality. Off-label use of the alpha-1 andrenergic receptor agonist midodrine to reduce the frequency and severity of IDH is common. However, limited data exist to support this practice. This study sought to examine real-world efficacy of midodrine with respect to relevant clinical and hemodynamic outcomes. METHODS: Here, we compared a variety of clinical and hemodynamic outcomes among adult patients who were prescribed midodrine (n = 1,046) and matched controls (n = 2,037), all of whom were receiving in-center hemodialysis treatment at dialysis facilities in the United States (July 2015 - September 2016)...
November 13, 2018: American Journal of Nephrology
Thijs T Jansz, Franka E van Reekum, Akin Özyilmaz, Pim A de Jong, Franciscus T J Boereboom, Tiny Hoekstra, Marianne C Verhaar, Brigit C van Jaarsveld
BACKGROUND: Vascular calcification is seen in most patients on dialysis and is strongly associated with cardiovascular mortality. Vascular calcification is promoted by phosphate, which generally reaches higher levels in hemodialysis than in peritoneal dialysis. However, whether vascular calcification develops less in peritoneal dialysis than in hemodialysis is currently unknown. Therefore, we compared coronary artery calcification (CAC), its progression, and calcification biomarkers between patients on hemodialysis and peritoneal dialysis...
November 13, 2018: American Journal of Nephrology
Lucile Mercadal, Sophie Tezenas du Montcel, Michel B Chonchol, Alain Debure, Hélène Depreneuf, Aude Servais, Nader Bassilios, Ubald Assogba, Mahmoud Allouache, Dominique Prié
BACKGROUND: The use of L-carnitine has been proposed in haemodialysis (HD) when deficiency is present to improve anaemia resistant to erythropoietin stimulating agent, intradialytic hypotension or cardiac failure. We tested the effects of L-carnitine supplementation on parameters of chronic kidney disease-mineral bone disorder. METHODS: CARNIDIAL was a randomized, double-blinded trial having included 92 incident HD subjects for a 1-year period to receive L-carnitine versus placebo...
November 8, 2018: American Journal of Nephrology
Laura-Gabriela Sánchez-Lozada, Fernando E García-Arroyo, Guillermo Gonzaga, Octaviano Silverio, Mónica G Blas-Marron, Itzel Muñoz-Jimenez, Edilia Tapia, Horacio Osorio-Alonso, Magdalena Madero, Carlos A Roncal-Jiménez, Ilana Weiss, Jason Glaser, Richard J Johnson
BACKGROUND: Heat stress and rhabdomyolysis are major risk factors for the occurrence of repeated acute kidney injury in workers exposed to heat and strenuous work. These episodes, in turn, may progress to chronic kidney disease. OBJECTIVE: The purpose of this study was to test the effect of allopurinol (AP) and sodium bicarbonate on the kidney injury induced by recurrent heat stress dehydration with concomitant repeated episodes of rhabdomyolysis. METHODS: The model consisted of heat stress exposure (1 h, 37°C) plus rhabdomyolysis (R) induced by repetitive IM injections of glycerol (7...
November 2, 2018: American Journal of Nephrology
Beini Lyu, Tanushree Banerjee, Julia J Scialla, Tariq Shafi, Alexander S Yevzlin, Neil R Powe, Rulan S Parekh, Brad C Astor
BACKGROUND: Arteriovenous (AV) access dysfunction is a common complication in hemodialysis patients. Markers of vascular calcification are associated with cardiovascular outcomes and mortality in this population, but their association with vascular access outcomes is unknown. In this study, we aimed to evaluate the association between selected vascular calcification makers and vascular access complications in a cohort of hemodialysis patients. METHOD: Fetuin-A, osteopontin (OPN), osteoprotegerin (OPG), and bone morphogenetic protein-7 (BMP-7) were measured in blood samples from 219 dialysis patients in the Choice for Healthy Outcomes in Caring for end-stage renal disease study; these patients were using a permanent vascular access...
October 31, 2018: American Journal of Nephrology
Stephen M Korbet, William L Whittier, Roger A Rodby
BACKGROUND: Percutaneous renal biopsy of native kidneys (PRB) has been an integral part of the practice of nephrology. However, over the past 30 years, PRB has transitioned from a procedure performed only by nephrologists to interventional radiologists (IRs). We surveyed practicing nephrologists completing training in our program to determine the clinical practice patterns of PRB. METHODS: The 78 fellows completing the nephrology program at Rush University Medical Center from June 1984 through June 2017 were successfully contacted and surveyed regarding their opinion on adequacy of their training and whether they performed PRB in practice and if not or no longer, why...
October 24, 2018: American Journal of Nephrology
George Kosmadakis, Julie Albaret, Enrique da Costa Correia, Frederic Somda, Didier Aguilera
BACKGROUND: Gastrointestinal (GI) disorders in peritoneal dialysis (PD) patients are relatively understudied in the literature, even though they have a serious impact in the morbidity parameters and the quality of life for this group of patients. Various diagnostic tools have been used, including instrumental methods and questionnaires, invariably validated in comparative studies. SUMMARY: The prevalence of GI disorders is very high in PD patients. Compared to the haemodialysis patients they present a higher prevalence of reflux, eating dysfunction, gastroesophageal reflux, intestinal obstruction or adhesions and abdominal hernia...
October 19, 2018: American Journal of Nephrology
Athanasios Bikos, Elena Angeloudi, Evangelos Memmos, Charalampos Loutradis, Antonios Karpetas, Evi Ginikopoulou, Stylianos Panagoutsos, Ploumis Pasadakis, Vassilios Liakopoulos, Aikaterini Papagianni, Pantelis Sarafidis
BACKGROUND: Short-term blood pressure (BP) variability (BPV) is associated with increased cardiovascular risk in hemodialysis. Patients with intradialytic hypertension have high risk of adverse outcomes. Whether BPV is increased in these patients is not clear. The purpose of this study was to compare short-term BPV in patients with and without intradialytic hypertension. METHODS: Forty-one patients with and 82 patients without intradialytic hypertension (intradialytic SBP rise ≥10 mm Hg to > 150 mm Hg) matched in a 1: 2 ratio for age, sex, and hemodialysis vintage were included...
2018: American Journal of Nephrology
Mónica Furlano, Irene Loscos, Teresa Martí, Gemma Bullich, Nadia Ayasreh, Asunción Rius, Lourdes Roca, José Ballarín, Elisabet Ars, Roser Torra
BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) causes the development of renal cysts and leads to a decline in renal function. Limited guidance exists in clinical practice on the use of tolvaptan. A decision algorithm from the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Working Groups of Inherited Kidney Disorders and European Renal Best Practice (WGIKD/ERBP) has been proposed to identify candidates for tolvaptan treatment; however, this algorithm has not been assessed in clinical practice...
2018: American Journal of Nephrology
Panagiotis I Georgianos, Rajiv Agarwal
No abstract text is available yet for this article.
2018: American Journal of Nephrology
Benjamin D Cowley
No abstract text is available yet for this article.
2018: American Journal of Nephrology
Yi-Ju Chen, Ling Yeung, Chi-Chin Sun, Chien-Chieh Huang, Kuo-Su Chen, Yi-Hsuan Lu
BACKGROUND: Age-related macular degeneration (AMD) is an important cause of blindness in aged people. Chronic kidney disease (CKD) was reported to be associated with a higher risk of AMD. However, supporting evidence was inconsistent between studies. This work intends to examine whether a positive association exists between CKD and AMD by systematic review and meta-analysis. METHODS: A systematic search of electronic databases (Medline, PubMed, Cochrane and EMBASE) and reference lists on June 2017...
2018: American Journal of Nephrology
Adil Jadoon, Anna V Mathew, Jaeman Byun, Crystal A Gadegbeku, Debbie S Gipson, Farsad Afshinnia, Subramaniam Pennathur
BACKGROUND: The gut microbiota is altered in patients with chronic kidney disease (CKD), and cardiovascular risk increases with progressive CKD. This study examined the potential link between short chain fatty acids (SCFAs), which are produced by the gut microbiota, and cardiovascular outcomes in patients with CKD. METHODS: SCFAs were measured using a targeted liquid chromatography-mass spectrometry platform in baseline plasma samples from 214 patients with CKD enrolled in the Clinical Phenotyping Resource and Biobank Core; 81 patients with coronary artery disease (CAD) and 133 without CAD were randomly assigned to training and validation subsets...
2018: American Journal of Nephrology
Iain C Macdougall, Claire White, Stefan D Anker, Sunil Bhandari, Kenneth Farrington, Philip A Kalra, John J V McMurray, Heather Murray, Retha Steenkamp, Charles R V Tomson, David C Wheeler, Christopher G Winearls, Ian Ford
BACKGROUND: Intravenous (IV) iron supplementation is a standard maintenance treatment for hemodialysis (HD) patients, but the optimum dosing regimen is unknown. METHODS: PIVOTAL (Proactive IV irOn Therapy in hemodiALysis patients) is a multicenter, open-label, blinded endpoint, randomized controlled (PROBE) trial. Incident HD adults with a serum ferritin < 400 µg/L and transferrin saturation (TSAT) levels < 30% receiving erythropoiesis-stimulating agents (ESA) were eligible...
2018: American Journal of Nephrology
Jalal Azmandian, Mohammad Reza Abbasi, Vahid Pourfarziani, Amir Ahmad Nasiri, Shahrzad Ossareh, Shahrokh Ezzatzadegan Jahromi, Hooshang Sanadgol, Somayeh Amini, Arshia Shahvaroughi Farahani
BACKGROUND: Anemia is one of the most prevalent complications in patients with chronic kidney disease, which is believed to be caused by the insufficient synthesis of erythropoietin by the kidney. This phase III study aimed to compare the efficacy and safety of CinnaPoietin® (epoetin beta, CinnaGen) with Eprex® (epoetin alfa, Janssen Cilag) in the treatment of anemia in ESRD hemodialysis patients. METHODS: In this randomized, active-controlled, double-blind, parallel, and non-inferiority trial, patients were randomized to receive either CinnaPoietin® or Eprex® for a 26-week period...
2018: American Journal of Nephrology
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