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American Journal of Nephrology

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https://www.readbyqxmd.com/read/29996127/serum-calcification-propensity-and-fetuin-a-biomarkers-of-cardiovascular-disease-in-kidney-transplant-recipients
#1
Andrew Bostom, Andreas Pasch, Tracy Madsen, Mary B Roberts, Nora Franceschini, Dominik Steubl, Pranav S Garimella, Joachim H Ix, Katherine R Tuttle, Anastasia Ivanova, Theresa Shireman, Reginald Gohh, Basma Merhi, Petr Jarolim, John W Kusek, Marc A Pfeffer, Simin Liu, Charles B Eaton
BACKGROUND: "T50," shortened transformation time from primary to secondary calciprotein particles may reflect deranged mineral metabolism predisposing to vascular calcification and cardiovascular disease (CVD). The glycoprotein fetuin-A is a major T50 determinant. METHODS: The Folic Acid For Vascular Outcome Prevention In Transplantation (FAVORIT) cohort is a completed, large, multiethnic controlled clinical trial cohort of chronic, stable kidney transplant recipients (KTRs)...
July 11, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29990994/gender-and-racial-disparities-in-initial-hemodialysis-access-and-outcomes-in-incident-end-stage-renal-disease-patients
#2
Silvi Shah, Anthony C Leonard, Karthikeyan Meganathan, Annette L Christianson, Charuhas V Thakar
BACKGROUND: Arteriovenous (AV) access confers survival benefits over central venous catheters (CVC) in hemodialysis patients. Although chronic kidney disease disproportionately affects women and racial minorities, disparities in the -utilization of hemodialysis access across Asians, Native Americans, Hispanics, blacks, and whites among males and females after accounting for pre-dialysis health are not well studied. METHODS: We evaluated 885,699 patients with end-stage renal disease who initiated hemodialysis between January 1, 2004 and December 31, 2014 using the US Renal Data System...
July 10, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29990967/re-evaluation-of-total-co2-concentration-in-apparently-healthy-younger-adults
#3
Jeffrey A Kraut, Vivian Lew, Nicolaos E Madias
The initial assessment of acid-base status is usually based on the measurement of total CO2 concentration ([TCO2]) in venous blood, a surrogate for [HCO3-]. Previously, we posited that the reference limits of serum [TCO2] in current use are too wide. Based on studies on the acid-base composition of normal subjects, we suggested that the reference limits of serum [TCO2] at sea level be set at 23-30 mEq/L. To validate this proposal, we queried the University of California at Los Angeles (UCLA's) Integrated Clinical and Research Data Repository, a database containing information on 4...
July 10, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29990962/vascular-access-differences-in-men-and-women-time-to-solve-the-problem
#4
EDITORIAL
Adeera Levin
No abstract text is available yet for this article.
July 10, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29791896/deterioration-of-cortical-bone-microarchitecture-critical-component-of-renal-osteodystrophy-evaluation
#5
Ashish K Sharma, Nigel D Toussaint, Rosemary Masterson, Stephen G Holt, Chamith S Rajapakse, Peter R Ebeling, Sindhu T Mohanty, Paul Baldock, Grahame J Elder
BACKGROUND: Cortical bone is a significant determinant of bone strength and its deterioration contributes to bone fragility. Thin cortices and increased cortical porosity have been noted in patients with chronic kidney disease (CKD), but the "Turnover Mineralization Volume" classification of renal osteodystrophy does not emphasize cortical bone as a key parameter. We aimed to assess trabecular and cortical bone microarchitecture by histomorphometry and micro-CT in patients with CKD G5 and 5D (dialysis)...
May 23, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29788030/cortical-or-trabecular-bone-what-s-the-difference
#6
EDITORIAL
Susan M Ott
No abstract text is available yet for this article.
May 22, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29895031/iatrogenesis-imperfecta-medicamentosa-adverse-drug-events-in-dialysis-patients-are-associated-with-higher-resource-utilization-and-mortality
#7
EDITORIAL
Daniel Blum, Christopher T Chan
No abstract text is available yet for this article.
2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29895030/national-trends-in-emergency-room-visits-of-dialysis-patients-for-adverse-drug-reactions
#8
Lili Chan, Aparna Saha, Priti Poojary, Kinsuk Chauhan, Nidhi Naik, Steven Coca, Pranav S Garimella, Girish N Nadkarni
BACKGROUND: Various medications are cleared by the kidneys, therefore patients with impaired renal function, especially dialysis patients are at risk for adverse drug events (ADEs). There are limited studies on ADEs in maintenance dialysis patients. METHODS: We utilized a nationally representative database, the Nationwide Emergency Department Sample, from 2008 to 2013, to compare emergency department (ED) visits for dialysis and propensity matched non-dialysis patients...
2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29895004/can-emergency-department-visits-for-adverse-drug-reactions-in-dialysis-patients-be-reduced
#9
EDITORIAL
Simit Doshi, Jay B Wish
No abstract text is available yet for this article.
2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29879718/acute-kidney-injury-before-dialysis-initiation-predicts-adverse-outcomes-in-hemodialysis-patients
#10
Timmy Lee, Silvi Shah, Anthony C Leonard, Pratik Parikh, Charuhas V Thakar
BACKGROUND: Acute kidney injury (AKI) is associated with increased morbidity and mortality. Mortality in end-stage renal disease (ESRD) patients is highest during the first year of dialysis. The impact of pre-ESRD AKI events on long-term outcomes in incident ESRD patients remains unknown. METHODS: We evaluated a retrospective cohort of 47,341 incident hemodialysis patients from the United States Renal Data System with linked Medicare data for at least 2 years prior to hemodialysis initiation...
2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29879715/recognizing-downstream-consequences-of-acute-kidney-injury
#11
EDITORIAL
Lenar Yessayan, Michael Heung
No abstract text is available yet for this article.
2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29879714/dialysate-potassium-and-mortality-in-a-prospective-hemodialysis-cohort
#12
Antoney Ferrey, Amy S You, Csaba P Kovesdy, Tracy Nakata, Mary Veliz, Danh V Nguyen, Kamyar Kalantar-Zadeh, Connie M Rhee
BACKGROUND: Studies examining the association of dialysate potassium concentration and mortality in hemodialysis patients show conflicting findings. We hypothesized that low dialysate potassium concentrations are associated with higher mortality, particularly in patients with high pre-dialysis serum potassium concentrations. METHODS: We evaluated 624 hemodialysis patients from the prospective Malnutrition, Diet, and Racial Disparities in Kidney Disease study recruited from 16 outpatient dialysis facilities over 2011-2015 who underwent protocolized collection of dialysis treatment characteristics every 6 months...
2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29874658/association-of-monocyte-chemoattractant-protein-1-with-death-and-atherosclerotic-events-in-chronic-kidney-disease
#13
L Parker Gregg, Maria Clarissa Tio, Xilong Li, Beverley Adams-Huet, James A de Lemos, S Susan Hedayati
BACKGROUND: Monocyte chemoattractant protein-1 -(MCP-1), a marker of inflammation and monocyte recruitment to atherosclerotic plaques, is associated with cardiovascular (CV) outcomes in patients with acute coronary syndrome. Although plasma levels are elevated in chronic kidney disease (CKD), associations with reduced kidney function or outcomes in CKD have not been explored. METHODS: In this population-based, probability-sampled, longitudinal cohort of 3,257 participants, including 286 (8...
2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29874654/ferric-citrate-decreases-fibroblast-growth-factor-23-and-improves-erythropoietin-responsiveness-in-hemodialysis-patients
#14
Noriaki Maruyama, Tomoyasu Otsuki, Yoshinori Yoshida, Chinami Nagura, Maki Kitai, Nami Shibahara, Hyoe Tomita, Takashi Maruyama, Masanori Abe
BACKGROUND: Serum phosphate and vitamin D receptor activator regulate fibroblast growth factor 23 (FGF23), and iron may modulate FGF23 metabolism. The aim of the present study was to elucidate the effects of ferric citrate hydrate and lanthanum carbohydrate on serum FGF23 levels in hemodialysis patients. METHODS: This prospective, open-label, multicenter study enrolled 60 patients on hemodialysis treated with lanthanum carbonate. Patients were randomly assigned to 2 groups: those switching from lanthanum carbonate to ferric citrate hydrate (ferric citrate group, n = 30) or those continuing lanthanum carbonate (control group, n = 30)...
2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29874651/corticosteroid-for-iga-nephropathy-are-they-really-therapeutic
#15
Yujia Lin, Junya Jia, Yipeng Guo, Dandan He, Yaru Zhang, Fuzhen Wang, Tiekun Yan, Youxia Liu, Shan Lin
BACKGROUND: IgA nephropathy (IgAN) is a common chronic glomerular disease that, in most patients, slowly progresses to end-stage kidney disease. The therapy with corticosteroid in IgAN is still a worldwide problem that is confusing the clinicians. METHODS: MEDLINE, EMBASE, the Cochrane Library, and article reference lists were searched for randomized controlled trials (RCTs) that compared corticosteroids with placebo and any other non-immunosuppressive agents in treating IgAN...
2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29860245/prelims-proteinuria-in-nephrotic-syndrome-mechanistic-and-clinical-considerations-in-optimizing-management
#16
(no author information available yet)
No abstract text is available yet for this article.
2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29852501/immunoglobulin-a-nephropathy-advances-in-understanding-of-pathogenesis-and-treatment
#17
Richard A Lafayette, Ellie Kelepouris
BACKGROUND: Immunoglobulin A (IgA) nephropathy is the most common form of primary glomerulonephritis and has clinical associations with a wide range of inflammatory and infectious diseases. There is a substantial variation in clinical course and outcomes, with many patients not diagnosed until they present with sequelae, which may include gross hematuria, hypertension, renal insufficiency, and/or significant proteinuria. Treatment options are currently limited and directed mainly toward control of these sequelae and have limited ability to reduce the incidence of end-stage renal disease or treat the primary IgA defect...
2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29852500/proteinuria-in-nephrotic-syndrome-mechanistic-and-clinical-considerations-in-optimizing-management
#18
James A Tumlin, Kirk N Campbell
No abstract text is available yet for this article.
2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29852493/protecting-podocytes-a-key-target-for-therapy-of-focal-segmental-glomerulosclerosis
#19
Kirk N Campbell, James A Tumlin
BACKGROUND: Focal segmental glomerulosclerosis (FSGS) is a histologic pattern of injury demonstrated by renal biopsy that can arise from a diverse range of causes and mechanisms. It has an estimated incidence of 7 per 1 million and is the most common primary glomerular disorder leading to end-stage renal disease in the United States. This review focuses on damage to the podocyte and the consequences of this injury in patients with FSGS, the genetics of FSGS, and approaches to treatment with a focus on the effects on podocytes...
2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29852492/a-review-of-podocyte-biology
#20
Puneet Garg
BACKGROUND: Podocyte biology is a developing science that promises to help improve understanding of the mechanistic nature of multiple diseases associated with proteinuria. Proteinuria in nephrotic syndrome has been linked to mechanistic dysfunctions in the renal glomerulus involving the function of podocyte epithelial cells, including podocyte foot process effacement. SUMMARY: Developments in imaging technology are improving knowledge of the detailed structure of the human renal glomerulus and cortex...
2018: American Journal of Nephrology
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