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American Journal of Nephrology

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https://www.readbyqxmd.com/read/27907919/the-impact-of-health-care-appointment-non-adherence-on-graft-outcomes-in-kidney-transplantation
#1
David J Taber, James N Fleming, Cory E Fominaya, Mulugeta Gebregziabher, Kelly J Hunt, Titte R Srinivas, Prabhakar K Baliga, John W McGillicuddy, Leonard E Egede
BACKGROUND: Non-adherence to medication is a well-studied and known cause of late allograft loss, but it is difficult to measure and prospectively monitor. The aim of this study was to assess if appointment non-adherence was correlated with medication non-adherence and a predictor of graft outcomes. METHODS: This was a longitudinal cohort study that used the National United States Renal Data System and veterans affairs health records data with time-to-event analyses conducted to assess the impact on graft and patient survival...
December 2, 2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27907917/simple-cysts-in-donor-kidney-contribute-to-reduced-allograft-function
#2
Wenxian Qiu, Yan Jiang, Jianyong Wu, Hongfeng Huang, Wenqing Xie, Xishao Xie, Jianghua Chen, Wenhan Peng
BACKGROUND: Simple renal cysts may be an early marker of renal disease. We investigated whether simple cysts in donor kidney are associated with the decline of allograft function in living donor kidney transplantation. METHODS: We retrospectively reviewed records of donors and recipients from 716 living donor kidney transplants performed between April 2007 and April 2015 in our hospital. Ninety-one donors with renal cysts and 64 recipients with cysts in donor kidney were noted...
December 2, 2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27907912/adherence-in-kidney-transplant-recipients
#3
Daniel Cukor
No abstract text is available yet for this article.
December 2, 2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27898424/arterial-stiffness-as-a-cardiovascular-risk-factor-in-stage-5d-chronic-kidney-disease-patients-an-age-affair
#4
Carmine Zoccali, Francesca Mallamaci
No abstract text is available yet for this article.
November 30, 2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27898419/high-pulse-wave-velocity-defines-a-very-high-cardiovascular-risk-cohort-of-dialysis-patients-under-age-60
#5
João Pedro Ferreira, Nicolas Girerd, Bruno Pannier, Patrick Rossignol, Gerard M London
BACKGROUND: Patients with end-stage renal disease (ESRD) are at a high risk of cardiovascular mortality (CVM). In patients with ESRD, arterial stiffness increases at an earlier age when compared to the general population and this contributes to the overall risk of cardiovascular mortality. The main objective of this study was to clarify the interplay between age and cardiovascular alterations in ESRD. METHODS: Prospective, observational cohort study initiated in April 1987 until the end of 1998 with events recorded until the end of the year 2000 at the F...
November 30, 2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27894119/trajectories-and-predictors-of-allograft-dysfunction-after-renal-transplantation-in-children
#6
Vandréa Carla de Souza, Muriel Rabilloud, Pierre Cochat, Mario Bernardes Wagner, Clotilde Druck Garcia, Bruno Ranchin, Jean Iwaz, Luciano Selistre, Laurence Dubourg
BACKGROUND: The survival rates of renal transplant children are indeed on the rise, but it is still important to ensure that there is optimal renal function in these children in all their future growing years. The number of functioning nephrons and the graft ability to adapt to an increasing demand during body growth seem to be the most important factors for long-term allograft function. This study examined the long-term change in the glomerular filtration rate in a pediatric kidney transplant cohort and the importance of the recipient and donor ages in predicting transplant outcome...
November 29, 2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27894115/complement-activation-related-pseudo-allergy-a-fresh-look-at-hypersensitivity-reactions-to-intravenous-iron
#7
Iain C Macdougall, Katherine Vernon
No abstract text is available yet for this article.
November 29, 2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27889746/distinct-in-vitro-complement-activation-by-various-intravenous-iron-preparations
#8
Julia Cordelia Hempel, Felix Poppelaars, Mariana Gaya da Costa, Casper F M Franssen, Thomas P G de Vlaam, Mohamed R Daha, Stefan P Berger, Marc A J Seelen, Carlo A J M Gaillard
BACKGROUND: Intravenous (IV) iron preparations are widely used in the treatment of anemia in patients undergoing hemodialysis (HD). All IV iron preparations carry a risk of causing hypersensitivity reactions. However, the pathophysiological mechanism is poorly understood. We hypothesize that a relevant number of these reactions are mediated by complement activation, resulting in a pseudo-anaphylactic clinical picture known as complement activation-related pseudo allergy (CARPA). METHODS: First, the in-vitro complement-activating capacity was determined for 5 commonly used IV iron preparations using functional complement assays for the 3 pathways...
November 26, 2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27880946/2md-dp001-a-single-agent-in-the-management-of-hemodialysis-patients-a-randomized-trial
#9
Ravi Thadhani, Julia B Zella, Danielle C Knutson, William J Blaser, Lori A Plum, Margaret Clagett-Dame, Raymond D Buck, Hector F DeLuca
BACKGROUND: Vitamin D analogs and calcimimetics are used to manage secondary hyperparathyroidism (SHPT) in dialysis patients. DP001 is an oral vitamin D analog that suppresses parathyroid hormone (PTH) in uremic rats, osteopenic women, and hemodialysis patients. The safety and effectiveness of DP001 suppressing PTH in dialysis patients previously managed with active vitamin D with or without a calcimimetic are presented. METHODS: A multicenter, randomized, double-blind study compared DP001 to placebo in hemodialysis patients with serum-intact PTH (iPTH) ≥300 pg/ml...
November 24, 2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27866208/kidney-cancer-linked-to-chronic-hepatitis-in-the-asia-pacific-a-population-based-analysis
#10
Yu-Shan Lin, Chih-Ching Yeh, Yen-Chung Lin, Chien-Tien Su, Fung-Chang Sung, Shih-Ni Chang, Yun-Ru Liu, Fu-Hsiung Su
BACKGROUND: The association of renal cancer with viral hepatitis infection remains unclear. Using an insurance data set, this population-based case-control study evaluated the association of renal cancer with chronic hepatitis virus infection in an endemic area of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. METHODS: We enrolled 17,747 patients with renal cancer during the period from 2000 to 2011 from the National Health Insurance Research Database of Taiwan...
November 19, 2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27866205/disparities-in-kidney-transplantation-access-among-korean-patients-initiating-dialysis-a-population-based-cohort-study-using-national-health-insurance-data-2003-2013
#11
Young Choi, Jaeyong Shin, Jung Tak Park, Kyoung Hee Cho, Eun-Cheol Park, Tae Hyun Kim
BACKGROUND: The socioeconomic status of a person has an impact on his or her access to kidney transplantation as has been reported in western countries. This study examined the association between income level and kidney transplantation among chronic kidney disease patients undergoing dialysis in South Korea. METHODS: We analyzed data from 1,792 chronic kidney disease patients undergoing dialysis and listed in the Korean National Health Insurance Claim Database (2003-2013)...
November 19, 2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27846632/vitamin-k-metabolism-in-a-rat-model-of-chronic-kidney-disease
#12
Kristin M McCabe, Sarah L Booth, Xueyan Fu, Emilie Ward, Michael A Adams, Rachel M Holden
BACKGROUND: Patients with chronic kidney disease (CKD) have very high levels of uncarboxylated, inactive, extra-hepatic vitamin K-dependent proteins measured in circulation, putting them at risk for complications of vitamin K deficiency. The major form of vitamin K found in the liver is phylloquinone (K1). Menaquinone-4 (MK-4) is the form of vitamin K that is preferentially found in extra-hepatic tissues. METHODS: In the present study, we assessed tissue concentrations of K1 and MK-4 and the expression of vitamin K-related genes in a rat model of adenine-induced CKD...
November 16, 2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27842304/vitamin-k-deficiency-in-chronic-kidney-disease-evidence-is-building-up
#13
Maria Fusaro, Mario Plebani, Giorgio Iervasi, Maurizio Gallieni
No abstract text is available yet for this article.
November 15, 2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27842302/effect-of-a-dialysis-access-coordinator-on-preemptive-access-placement-among-veterans-a-quality-improvement-initiative
#14
Randall C Gale, Doreen Kehoe, Yiming Z Lit, Steven M Asch, Manjula Kurella Tamura
BACKGROUND AND OBJECTIVES: Preemptive placement of permanent dialysis access is recommended in order to reduce the morbidity associated with central venous catheters. We assessed the effect of a dialysis access coordinator on preemptive access placement in veterans who are at high risk for end-stage renal disease (ESRD). DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: Pre-post evaluation of a dialysis access coordinator in the nephrology clinics of the Veterans Affairs Palo Alto...
November 15, 2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27802442/urinary-periostin-excretion-predicts-renal-outcome-in-iga-nephropathy
#15
Jin Ho Hwang, Jung Pyo Lee, Clara Tammy Kim, Seung Hee Yang, Jin Hyuk Kim, Jung Nam An, Kyung Chul Moon, Hajeong Lee, Yun Kyu Oh, Kwon Wook Joo, Dong Ki Kim, Yon Su Kim, Chun Soo Lim
BACKGROUND: Periostin is a matricellular protein and plays a vital role in tissue regeneration, fibrosis and wound healing. However, data about its significance in nephrology are limited. We investigated the correlation between urinary periostin excretion and its clinical significance including renal histologic findings and prognosis in IgA nephropathy (IgAN). METHODS: Of 399 patients from a glomerulonephritis cohort recruited between January 2009 and December 2014, 314 were enrolled...
November 1, 2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27798939/impact-of-cognitive-function-change-on-mortality-in-renal-transplant-and-end-stage-renal-disease-patients
#16
Akhil Sharma, Jonathan Yabes, Saleem Al Mawed, Christine Wu, Carol Stilley, Mark Unruh, Manisha Jhamb
BACKGROUND: Limited evidence from small-scale studies, mainly involving end-stage renal disease (ESRD) patients, suggests that kidney transplantation may improve cognitive function. We examined changes in cognitive function after a kidney transplant and its association with survival in advanced chronic kidney disease (CKD)/ESRD patients. METHODS: In a prospective study design, cognitive performance of 90 patients (50.6 ± 13.1 years, 66.7% men, 27.8% blacks, 76% CKD stages 4-5) was assessed at the respective patients' residences using established neurocognitive tests...
November 1, 2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27798938/cognitive-impairment-in-advanced-chronic-kidney-disease-the-canadian-frailty-observation-and-interventions-trial
#17
Rukhsana Foster, Simon Walker, Ranveer Brar, Brett Hiebert, Paul Komenda, Claudio Rigatto, Leroy Storsley, Bhanu Prasad, Clara Bohm, Navdeep Tangri
BACKGROUND: Chronic kidney disease (CKD) affects more than one third of older adults, and is a strong risk factor for vascular disease and cognitive impairment. Cognitive impairment can have detrimental effects on the quality of life through decreased treatment adherence and poor nutrition and results in increased costs of care and early mortality. Though widely studied in hemodialysis populations, little is known about cognitive impairment in patients with pre-dialysis CKD. METHODS: Multicenter, cross-sectional, prospective cohort study including 385 patients with CKD stages G4-G5...
November 1, 2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27788522/vancomycin-trough-and-acute-kidney-injury-a-large-retrospective-cohort-study
#18
Kassem Hammoud, Michael Brimacombe, Alan Yu, Neil Goodloe, Wael Haidar, Wissam El Atrouni
BACKGROUND: The association between vancomycin trough (VT) and acute kidney injury (AKI) at the recommended doses remains controversial. METHODS: The authors conducted a retrospective, observational cohort study of 500 adult patients who received vancomycin for ≥72 h. Data collected included 2 main predictors: average VT (including only VTs before the occurrence of AKI), first VT and other possible risk factors for AKI. The baseline characteristics/variables between patients with AKI and patients with no AKI were compared...
October 28, 2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27788520/lifetime-cocaine-and-opiate-use-and-chronic-kidney-disease
#19
Tessa Novick, Yang Liu, Anika Alvanzo, Alan B Zonderman, Michele K Evans, Deidra C Crews
BACKGROUND: More than 50% of American adolescents and adults report having used illicit drugs in their lifetime. We examined the association of lifetime opiate and cocaine use with reduced kidney function, albuminuria and rapid kidney function decline among urban-dwelling adults. METHODS: Our prospective cohort included 2,286 Healthy Aging in Neighborhoods of Diversity across the Life Span study participants who were community-dwelling adults residing in Baltimore, MD...
October 28, 2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27788507/vancomycin-trough-levels-cause-or-result-of-acute-kidney-injury
#20
William M Bennett
No abstract text is available yet for this article.
October 28, 2016: American Journal of Nephrology
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