A Case Series of Nephrotic Syndrome: A Harbinger of Catastrophic Oncologic Diseases.

INTRODUCTION: A cancer patient can have numerous complications involving the kidneys, ranging from acute kidney injury, chronic kidney disease, glomerulopathies, electrolyte, and acid-base disorders. It can be due to the malignancy itself or due to chemotherapeutic agents. Paraneoplastic glomerulopathy is a rare presentation of neoplastic disease.

CASE DISCUSSION: We present a case series of two patients presenting with nephrotic syndrome as a paraneoplastic syndrome associated with a gynecologic tumor. Both patients responded only partially to steroids and immunosuppressive therapy. Complete remission was only achieved after treatment of primary malignancy.

CONCLUSION: It is critical to recognize this entity as immunosuppression may induce a flare in the tumor course and worsen outcomes. So, age-appropriate screening of malignancy should ideally be performed in any adult patient with nephrotic syndrome.