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Journal Article
Research Support, N.I.H., Extramural
Cancer immunity derailed: PGE 2 misconducts cDC1s.
Immunity 2023 June 14
Type 1 conventional dendritic cells (cDC1s) are critical for CD8+ T cell-mediated tumor control. In this issue of Immunity, Bayerl et al.1 expose a mechanism leading to cancer progression where prostaglandin E2 induces dysfunctional cDC1s, which cannot coordinate CD8+ T cell migration and expansion.
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