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T-SPOT.TB reactivity in Southern African children with and without in utero HIV exposure.

Saori C Iwase, Paul T Edlefsen, Lynnette Bhebhe, Kessy Motsumi, Sikhulile Moyo, Anna-Ursula Happel, Danica Shao, Nicholas Mmasa, Sara Schenkel, Melanie A Gasper, Melanie Dubois, Megan A Files, Chetan Seshadri, Fergal Duffy, John Aitchison, Mihai G Netea, Jennifer Jao, Donald W Cameron, Clive M Gray, Heather B Jaspan, Kathleen M Powis
Clinical Infectious Diseases 2023 June 10
Infants HIV-exposed uninfected (iHEU) experience higher risk of infectious morbidity than infants HIV-unexposed uninfected (iHUU). We compared TB infection prevalence in 418 Bacillus Calmette-Guérin vaccinated sub-Saharan African iHEU and iHUU aged 9-18 months using T-SPOT.TB. Prevalence of TB infection was low and did not differ by HIV exposure status.

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