Prospective of Agro-Waste Husks for Biogenic Synthesis of Polymeric-Based CeO 2 /NiO Nanocomposite Sensor for Determination of Mebeverine Hydrochloride.

BACKGROUND: The remarkable properties of nickel oxide (NiO) and cerium oxide (CeO2 ) nanostructures have attracted considerable interest in these nanocomposites as potential electroactive materials for sensor construction.

METHODS: The mebeverine hydrochloride (MBHCl) content of commercial formulations was determined in this study using a unique factionalized CeO2 /NiO-nanocomposite-coated membrane sensor.

RESULTS: Mebeverine-phosphotungstate (MB-PT) was prepared by adding phosphotungstic acid to mebeverine hydrochloride and mixing with a polymeric matrix (polyvinyl chloride, PVC) and plasticizing agent o -nitrophenyl octyl ether. The new suggested sensor showed an excellent linear detection range of the selected analyte at 1.0 × 10-8 -1.0 × 10-2 mol L-1 with regression equation EmV = (-29.429 ± 0.2) log [MB] + 347.86. However, the unfunctionalized sensor MB-PT displayed less linearity at 1.0 × 10-5- 1.0 × 10-2 mol L-1 drug solution with regression equation EmV = (-26.603 ± 0.5) log [MB] + 256.81. By considering a number of factors, the applicability and validity of the suggested potentiometric system were improved following the rules of analytical methodological requirements.

CONCLUSION: The created potentiometric technique worked well for determining MB in bulk substance and in medical commercial samples.