journal
MENU ▼
Read by QxMD icon Read
search

Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry

journal
https://www.readbyqxmd.com/read/30413118/mitigation-effects-of-a-novel-herbal-medicine-hepad-on-neuroinflammation-neuroapoptosis-and-neuro-oxidation
#1
Da Hye Song, Gyeong-Ji Kim, Kwon Jai Lee, Jae Soo Shin, Dong-Hee Kim, Byung-Jun Park, Jeung Hee An
Parkinson's disease (PD), a common adult-onset neurodegenerative disorder with complex pathological mechanisms, is characterized by the degeneration of dopaminergic nigrostriatal neurons. The present study demonstrated that the herbal medicines Hepad 1 and 2 protected against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity in C57BL/6 mice and SH-SY5Y cells. Hepad 1 and 2 remarkably alleviated the enhanced expression of pro-inflammatory cytokines (tumor necrosis factor-α, interleukin-6, inducible nitric oxide synthase, cyclooxygenase-2, macrophage-1, and phosphorylated iκB-α) and apoptotic signals (Bcl-2-associated X protein, caspase-3, and poly [ADP-ribose] polymerase-1)...
November 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30413117/rosmarinic-acid-derivatives-inhibition-of-glycogen-synthase-kinase-3%C3%AE-is-the-pharmacological-basis-of-kangen-karyu-in-alzheimer-s-disease
#2
Pradeep Paudel, Su Hui Seong, Yajuan Zhou, Chan Hum Park, Takako Yokozawa, Hyun Ah Jung, Jae Sue Choi
Inhibition of glycogen synthase kinase 3β (GSK-3β) is considered to be the central therapeutic approach against Alzheimer's disease (AD). In the present study, boiled water extracts of the Kangen-karyu (KK) herbal mixture and its constituents were screened for GSK-3β inhibitory activity. KK is used in traditional Kampo and Chinese medicines for improving cognitive function. The GSK-3β inhibition potential was evaluated by using the Kinase-Glo luminescent kinase assay platform. Furthermore, enzyme kinetics and in silico modeling were performed by using AutoDockTools to demonstrate the mechanism of enzyme inhibition...
November 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30413113/a-novel-venom-derived-peptide-for-brachytherapy-of-glioblastoma-preclinical-studies-in-mice
#3
Steve Swenson, Radu O Minea, Cao Duc Tuan, Thu-Zan Thein, Thomas C Chen, Francis S Markland
We developed a bacterial expression system to produce a recombinant disintegrin, vicrostatin (VCN), whose structure is based on a natural disintegrin isolated from southern copperhead snake venom. Our goal is to develop VCN for potential clinical translation as an anti-cancer agent. VCN is a peptide of 69 amino acids with a single tyrosine residue. We have employed VCN as integrin-targeted radionuclide therapy (brachytherapy) for treatment of glioblastoma (GBM, glioma). GBM is a deadly brain cancer that doesn't discriminate between sexes and knows no age limit...
November 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30413097/complete-chloroplast-genome-sequence-of-malus-hupehensis-genome-structure-comparative-analysis-and-phylogenetic-relationships
#4
Xin Zhang, Chunxiao Rong, Ling Qin, Chuanyuan Mo, Lu Fan, Jie Yan, Manrang Zhang
Malus hupehensis belongs to the Malus genus (Rosaceae) and is an indigenous wild crabapple of China. This species has received more and more attention, due to its important medicinal, and excellent ornamental and economical, values. In this study, the whole chloroplast (cp) genome of Malus hupehensis , using a Hiseq X Ten sequencing platform, is reported. The M. hupehensis cp genome is 160,065 bp in size, containing a large single copy region (LSC) of 88,166 bp and a small single copy region (SSC) of 19,193 bp, separated by a pair of inverted repeats (IRs) of 26,353 bp...
November 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30413083/the-effects-of-different-degrees-of-procyanidin-polymerization-on-the-nutrient-absorption-and-digestive-enzyme-activity-in-mice
#5
Huairong Zhong, Yong Xue, Xiaoyuan Lu, Qiang Shao, Yuelei Cao, Zhaoxia Wu, Gao Chen
Proanthocyanidins, including polymers with both low and high degrees of polymerization, are the focus of intensive research worldwide due to their high antioxidant activity, medicinal applications, and pharmacological properties. However, the nutritional value of these compounds is limited because they readily form complexes with proteins, polysaccharides, and metal ions when consumed. In this study, we examined the effects of proanthocyanidins with different degrees of polymerization on white mice. Twenty-four male white mice were randomly divided into three groups of eight mice each and fed proanthocyanidins with a low degree of polymerization or a high degree of polymerization or a distilled water control via oral gavage over a 56-day period...
November 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30413079/heparan-sulfate-mimetics-in-cancer-therapy-the-challenge-to-define-structural-determinants-and-the-relevance-of-targets-for-optimal-activity
#6
REVIEW
Cinzia Lanzi, Giuliana Cassinelli
Beyond anticoagulation, the therapeutic potential of heparin derivatives and heparan sulfate (HS) mimetics (functionally defined HS mimetics) in oncology is related to their ability to bind and modulate the function of a vast array of HS-binding proteins with pivotal roles in cancer growth and progression. The definition of structural/functional determinants and the introduction of chemical modifications enabled heparin derivatives to be identified with greatly reduced or absent anticoagulant activity, but conserved/enhanced anticancer activity...
November 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30413071/bioactive-natural-spirolactone-type-6-7-seco-ent-kaurane-diterpenoids-and-synthetic-derivatives
#7
REVIEW
Haonan Li, Runwei Jiao, Jiahui Mu, Shengtao Xu, Xu Li, Xianhua Wang, Zhanlin Li, Jinyi Xu, Huiming Hua, Dahong Li
Diterpenoids are widely distributed natural products and have caused considerable interest because of their unique skeletons and antibacterial and antitumor activities and so on. In light of recent discoveries, ent -kaurane diterpenoids, which exhibit a wide variety of biological activities, such as anticancer and anti-inflammatory activities, pose enormous potential to serve as a promising candidate for drug development. Among them, spirolactone-type 6,7- seco - ent -kaurane diterpenoids, with interesting molecular skeleton, complex oxidation patterns, and bond formation, exhibit attractive activities...
November 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30413058/design-synthesis-molecular-modeling-and-biological-evaluation-of-novel-thiouracil-derivatives-as-potential-antithyroid-agents
#8
Samir M Awad, Yasser M Zohny, Sahar A Ali, Shahenda Mahgoub, Ahmed M Said
Hyperthyroidism is the result of uncontrolled overproduction of the thyroid hormones. One of the mostly used antithyroid agents is 6- n- propyl-2-thiouracil (PTU). The previously solved X-ray crystal structure of the PTU bound to mammalian lactoperoxidase (LPO) reveals that the LPO-PTU binding site is basically a hydrophobic channel. There are two hydrophobic side chains directed towards the oxygen atom in the C-4 position of the thiouracil ring. In the current study, the structural activity relationship (SAR) was performed on the thiouracil nucleus of PTU to target these hydrophobic side chains and gain more favorable interactions and, in return, more antithyroid activity...
November 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30413028/inhibitory-effects-of-ginsenoside-rb1-on-early-atherosclerosis-in-apoe-mice-via-inhibition-of-apoptosis-and-enhancing-autophagy
#9
Ping Zhou, Weijie Xie, Yun Luo, Shan Lu, Ziru Dai, Ruiying Wang, Xuelian Zhang, Guang Li, Guibo Sun, Xiaobo Sun
Inflammation is a major contributing factor to the progression of atherosclerosis. Ginsenoside Rb1 (Rb1), an active saponin of Panax notoginseng , has been found to exert beneficial effects on inflammation and oxidative stress. This study investigated the ability of Rb1 to inhibit the formation of atherosclerotic plaques and the potential mechanisms. In this study, the effects of Rb1 on the development of atherosclerosis were investigated in ApoE-/- deficient mice fed with a western diet. Mice were intragastrically administrated with Rb1 (10 mg/kg) for 8 weeks...
November 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30413024/carbonic-anhydrase-inhibitors-as-novel-drugs-against-mycobacterial-%C3%AE-carbonic-anhydrases-an-update-on-in-vitro-and-in-vivo-studies
#10
REVIEW
Ashok Aspatwar, Jean-Yves Winum, Fabrizio Carta, Claudiu T Supuran, Milka Hammaren, Mataleena Parikka, Seppo Parkkila
Mycobacteria cause a variety of diseases, such as tuberculosis, leprosy, and opportunistic diseases in immunocompromised people. The treatment of these diseases is problematic, necessitating the development of novel treatment strategies. Recently, β-carbonic anhydrases (β-CAs) have emerged as potential drug targets in mycobacteria. The genomes of mycobacteria encode for three β-CAs that have been cloned and characterized from Mycobacterium tuberculosis (Mtb) and the crystal structures of two of the enzymes have been determined...
November 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30413009/in-silico-analysis-of-bioactive-peptides-released-from-giant-grouper-epinephelus-lanceolatus-roe-proteins-identified-by-proteomics-approach
#11
Fenny Crista A Panjaitan, Honey Lyn R Gomez, Yu-Wei Chang
Major proteins contained in dried giant grouper roe (GR) such as vitellogenin (from Epinephelus coioides ; NCBI accession number: AAW29031.1), apolipoprotein A-1 precursor (from Epinephelus coioides ; NCBI accession number: ACI01807.1) and apolipoprotein E (from Epinephelus bruneus ; NCBI accession number: AEB31283.1) were characterized through compiled proteomics techniques (SDS-PAGE, in-gel digestion, mass spectrometry and on-line Mascot database analysis). These proteins were subjected to in silico analysis using BLAST and BIOPEP-UWM database...
November 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30413008/antiproliferative-activity-of-combined-biochanin-a-and-ginsenoside-rh%C3%A2-on-mda-mb-231-and-mcf-7-human-breast-cancer-cells
#12
Guixing Ren, Zhenxing Shi, Cong Teng, Yang Yao
Breast cancer is the most frequently diagnosed cancer in women worldwide. The antiproliferative activities of biochanin A (BA) and ginsenoside Rh₂ were determined by evaluating their inhibitory effect on MDA-MB-231 human breast cancer cell proliferation. The combination of BA with Rh₂ was also assessed. In MDA cells, combination treatment led to a decrease in the EC50 values of BA and Rh₂ to 25.20 μM and 22.75 μM, respectively. In MCF-7 cells, the EC50 values of combined BA and Rh₂ decreased to 27...
November 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30413007/isolation-of-chavibetol-and-methyleugenol-from-essential-oil-of-pimenta-pseudocaryophyllus-by-high-performance-liquid-chromatography
#13
Edenilson Dos Santos Niculau, Leandro do Prado Ribeiro, Thiago Felipe Ansante, João Batista Fernandes, Moacir Rossi Forim, Paulo Cezar Vieira, José Djair Vendramim, Maria Fátima das Graças Fernandes da Silva
A high performance liquid chromatography (HPLC) method was developed for the simultaneous isolation, on a semi-preparative scale, of chavibetol and methyleugenol from the crude essential oil of P. pseudocaryophyllus leaves. The purity of the isolated compounds and their quantifications were developed using GC/FID. Chavibetol was isolated with high purity (98.7%) and mass recovery (94.6%). The mass recovery (86.4%) and purity (85.3%) of methyleugenol were lower than those of chavibetol. Both compounds were identified on the basis of spectral analysis...
November 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30412997/variety-identification-of-raisins-using-near-infrared-hyperspectral-imaging
#14
Lei Feng, Susu Zhu, Chu Zhang, Yidan Bao, Pan Gao, Yong He
Different varieties of raisins have different nutritional properties and vary in commercial value. An identification method of raisin varieties using hyperspectral imaging was explored. Hyperspectral images of two different varieties of raisins (Wuhebai and Xiangfei) at spectral range of 874⁻1734 nm were acquired, and each variety contained three grades. Pixel-wise spectra were extracted and preprocessed by wavelet transform and standard normal variate, and object-wise spectra (sample average spectra) were calculated...
November 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30405089/co-delivery-of-gemcitabine-and-paclitaxel-in-crgd-modified-long-circulating-nanoparticles-with-asymmetric-lipid-layers-for-breast-cancer-treatment
#15
Jing Zhang, Peng Zhang, Qian Zou, Xiang Li, Jianjiang Fu, Ying Luo, Xinli Liang, Yi Jin
Combination chemotherapy is a common clinical practice in cancer treatment. Here, cyclic RGD (arginylglycylaspartic acid) peptide was introduced to the surface of lipid/calcium/phosphate (LCP) asymmetric lipid layer nanoparticles for the co-delivery of paclitaxel (PTX) and gemcitabine monophosphate (GMP) (P/G-NPs). The sphere-like morphology of P/G-NPs displays a well-distributed particle size, and high entrapment efficiency and drug loading for both PTX and GMP, with a positive zeta potential. P/G-NPs were stable for up to 15 days...
November 7, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30405073/gas-phase-hydrogenation-of-furaldehydes-via-coupling-with-alcohol-dehydrogenation-over-ceria-supported-au-cu
#16
Chiara Pischetola, Laura Collado, Mark A Keane, Fernando Cárdenas-Lizana
We have investigated the synthesis and application of Au-Cu/CeO₂ (Cu: Au = 2) in the continuous gas phase ( P = 1 atm; T = 498 K) coupled hydrogenation of 5-hydroxymethyl-2-furaldehyde (HMF) with 2-butanol dehydrogenation. STEM-EDX analysis revealed a close surface proximity of both metals in Au-Cu/CeO₂ post -TPR. XPS measurements suggest (support → metal) charge transfer to form Au δ - and strong metal-support interactions to generate Cu⁰ and Cu⁺. Au-Cu/CeO₂ promoted the sole formation of 2,5-dihydroxymethylfuran (DHMF) and 2-butanone in the HMF/2-butanol coupling with full hydrogen utilisation...
November 7, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30405065/identification-of-a-2-o-methyluridine-nucleoside-hydrolase-using-the-metagenomic-libraries
#17
Agota Aučynaitė, Rasa Rutkienė, Daiva Tauraitė, Rolandas Meškys, Jaunius Urbonavičius
Ribose methylation is among the most ubiquitous modifications found in RNA. 2'- O -methyluridine is found in rRNA, snRNA, snoRNA and tRNA of Archaea , Bacteria , and Eukaryota . Moreover, 2'- O -methylribonucleosides are promising starting materials for the production of nucleic acid-based drugs. Despite the countless possibilities of practical use for the metabolic enzymes associated with methylated nucleosides, there are very few reports regarding the metabolic fate and enzymes involved in the metabolism of 2'- O -alkyl nucleosides...
November 7, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30405051/anti-cancer-drug-sensitivity-assay-with-quantitative-heterogeneity-testing-using-single-cell-raman-spectroscopy
#18
Yong Zhang, Jingjing Xu, Yuezhou Yu, Wenhao Shang, Anpei Ye
A novel anti-cancer drug sensitivity testing (DST) approach was developed based on in vitro single-cell Raman spectrum intensity (RSI). Generally, the intensity of Raman spectra (RS) for a single living cell treated with drugs positively relates to the sensitivity of the cells to the drugs. In this study, five cancer cell lines (BGC 823, SGC 7901, MGC 803, AGS, and NCI-N87) were exposed to three cytotoxic compounds or to combinations of these compounds, and then they were evaluated for their responses with RSI...
November 7, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30405045/synthesis-of-jacaranone-derived-nitrogenous-cyclohexadienones-and-their-antiproliferative-and-antiprotozoal-activities
#19
Armin Presser, Gunda Lainer, Nadine Kretschmer, Wolfgang Schuehly, Robert Saf, Marcel Kaiser, Marc-Manuel Kalt
The cytotoxic and antiprotozoal activities of the phytoquinoide, jacaranone, and related compounds have been an ongoing topic in recent drug discovery. Starting from the natural product-derived cyclohexadienone scaffold, a series of nitrogen-containing derivatives were synthesized and subsequently evaluated for their antiproliferative and antiprotozoal activity. Anticancer potency was analyzed using different types of cancer cell lines: MDA-MB-231 breast cancer, CCRF-CEM leukemia, HCT-116 colon cancer, U251 glioblastoma, and, in addition, non-tumorigenic MRC-5 lung fibroblasts...
November 7, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30405042/chiral-separation-of-the-phenylglycinol-enantiomers-by-stripping-crystallization
#20
Lie-Ding Shiau
Stripping crystallization (SC) is introduced in this work for chiral purification of R -phenylglycinol from the enantiomer mixture with an initial concentration ranging from 0.90 to 0.97. As opposed to the solid⁻liquid transformation in melt crystallization, the three-phase transformation occurs in SC at low pressures during the cooling process. SC combines melt crystallization and vaporization to produce a crystalline product and mixture vapor from a mixture melt due to the three-phase transformation. Thermodynamic calculations were applied to determine the operating pressure for the three-phase transformation during the cooling process in the SC experiments...
November 7, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
journal
journal
35164
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"