Bilateral Wilms Tumor in CLOVES Syndrome.

Wilms tumor (WT) is the most common pediatric renal mas and occurs in up to ten percent of predisposition syndromes. One such syndrome is CLOVES syndrome, an extremely rare disorder within the umbrella of PIK3CA-Related Overgrowth Spectrum (PROS) disorders. This case presents the management of bilateral WT in a patient with CLOVES syndrome and highlights the many intricacies in caring for complex oncology patients. Particularly highlighted in this case is the delicate line in balancing the risks of treatment-related morbidity against the risks of recurrence in predisposed patients, while still abiding by established treatment guidelines.