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Urology

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https://www.readbyqxmd.com/read/28104422/tipless-nitinol-stone-baskets-comparison-of-penetration-force-radial-dilation-force-opening-dynamics-and-deflection
#1
Nishant Patel, Arash Akhavein, Bryan Hinck, Rajat Jain, Manoj Monga
OBJECTIVE: To evaluate 5 commercially available tipless nitinol baskets (2.2F) in 4performance factors: penetration force, radial dilation force, opening dynamics and deflection limitation. MATERIAL AND METHODS: The 2.2F Coloplast Dormia No-Tip®, 1.5F Sacred Heart Medical Halo®, 2.2F Cook NCircle Nitinol Tipless Stone Extractor ®, 1.9F Bard SkyLite Tipless Nitinol Basket® and the 1.9F Boston Scientific Zero TipTM baskets were tested for penetration force (safety metric), radial dilation force (functional metric for ureteral calculi), and opening/closing dynamics...
January 16, 2017: Urology
https://www.readbyqxmd.com/read/28104421/assessing-cancer-progression-and-stable-disease-after-neoadjuvant-chemotherapy-for-organ-confined-muscle-invasive-bladder-cancer
#2
Meera R Chappidi, Max Kates, Aaron Brant, Alexander S Baras, George J Netto, Phillip M Pierorazio, Noah M Hahn, Trinity J Bivalacqua
OBJECTIVE: To propose and validate a new approach to stratify clinically staged organ-confined muscle-invasive bladder cancer patients (cT2N0M0) that are pathologic non-responders to neoadjuvant chemotherapy (NAC) to better characterize NAC non-response. METHODS: We retrospectively identified radical cystectomy patients with cT2N0M0 disease at our institution (2005-2014) and in the National Cancer Database (NCDB, 2004-2012) for external validation. Patients were stratified as stable (pT2N0M0) or progressors (>pT2 and/or pN+)...
January 16, 2017: Urology
https://www.readbyqxmd.com/read/28104420/use-of-a-novel-flexible-mini-nephroscope-in-minimally-invasive-percutaneous-nephrolithotomy
#3
Dilip Kumar Mishra, Madhu Sudan Agrawal
OBJECTIVE: To assess the feasibility and safety of a novel flexible mini-nephroscope in minimally-invasive PCNL. Presumably, limiting the size and number of tracts during percutaneous-nephrolithotomy(PCNL) has the potential of decreasing the morbidity of the procedure. We present our experience with, this new technique. METHODS: A retrospective analysis of patients with multiple kidney stones treated with mini-PCNL combined with a novel flexible mini-nephroscope was performed...
January 16, 2017: Urology
https://www.readbyqxmd.com/read/28104419/pelvic-hardware-eroding-into-the-bladder-a-rare-case-presentation-of-gross-hematuria-bladder-pain-and-refractory-luts
#4
Kristen E Gurtner, Jonathan A Israel, Michael R Pinsky, James F Mautner, June B Miguez, Daniel J Canter
We present a 60 year-old male who presented with gross hematuria, refractory lower urinary tract symptoms, and increasing bladder pain for 3 months. The patient had a prior history of a motorcycle accident and pelvic fracture requiring an extensive pelvic open reduction and internal fixation. During evaluation, the patient was found to have an orthopedic screw from his hardware eroding through the left lateral wall of his bladder and irritating his trigone. The patient underwent pelvic exploration with open cystotomy and hardware removal with the orthopedic service...
January 16, 2017: Urology
https://www.readbyqxmd.com/read/28094045/quantification-of-user-and-manufacturer-variabilities-in-urinary-catheter-anchoring-balloon-inflation-and-mitigation-of-variability-by-flow-resistance
#5
Niall F Davis, Eoghan M Cunnane, Rory C Mooney, Rustom P Manecksha, John A Thornhill, Michael T Walsh
OBJECTIVE: To quantify user variability and manufacturer variability in urinary catheter anchoring balloon inflation pressure and to mitigate any significant variance by incorporating flow resistance into the anchoring balloon inflation process. METHODS: Inflation of a urinary catheter anchoring balloon was performed at atmospheric pressure by different users (n = 8) to investigate user variability. A calibrated pressure transducer measured inflation pressures, and a video extensometer measured balloon inflation profiles...
January 13, 2017: Urology
https://www.readbyqxmd.com/read/28093308/antibiotic-coating-of-the-artificial-urinary-sphincter-ams-800-%C3%A2-is-it-worthwhile
#6
Tanja Hüsch, Alexander Kretschmer, Frauke Thomsen, Dominik Kronlachner, Martin Kurosch, Alice Obaje, Ralf Anding, Tobias Pottek, Achim Rose, Roberto Olianas, Alexander Friedl, Wilhelm Hübner, Roland Homberg, Jesco Pfitzenmaier, Ulrich Grein, Fabian Queissert, Carsten M Naumann, Josef Schweiger, Carola Wotzka, Joanne Nyarangi-Dix, Torben Hofmann, Kurt Ulm, Ricarda M Bauer, Axel Haferkamp
OBJECTIVES: To investigate the impact of the antibiotic coating InhibiZone(®) on the infection and explantation rates of the AMS 800(®) in comparison to the AMS 800(®) without InhibiZone(®). METHODS: We retrospectively identified 305 patients with an AMS 800(®) in a multicenter cohort study. Patients were subsequently divided into InhibiZone(®) and without InhibiZone(®)-coated groups. Infection as well as explantation rates were analysed by univariate and consecutively by multivariate logistic regression adjusted to variable risk factors...
January 13, 2017: Urology
https://www.readbyqxmd.com/read/28093307/the-impact-of-baseline-functional-bladder-capacity-on-short-term-neuromodulation-outcomes
#7
Kim A Killinger, Priyanka Gupta, Jason P Gilleran, Jamie Bartley, Michael Ehlert, Judith A Boura, Kenneth M Peters
OBJECTIVES: To evaluate the impact of functional bladder capacity (FBC) on clinical outcomes after a staged neuromodulation procedure. METHODS: Adults in our prospective neuromodulation database were evaluated. Data were collected from medical records, voiding diaries (FBC defined as average volume per void), Interstitial Cystitis Symptom/Problem Indices (ICSI-PI), Overactive Bladder Questionnaires (OAB-q), and Global Response Assessments over 3 months. Descriptive statistics, Pearson's Chi-square tests, Wilcoxon rank sum tests, logistic regression, repeated measures analyses and Spearman Correlation Coefficients were performed...
January 13, 2017: Urology
https://www.readbyqxmd.com/read/28089885/variable-pulse-duration-from-a-new-ho-yag-laser-the-effect-on-stone-comminution-fiber-tip-degradation-and-retropulsion-in-a-dusting-model
#8
Daniel A Wollin, Anika Ackerman, Chen Yang, Tony Chen, Walter Neal Simmons, Glenn M Preminger, Michael E Lipkin
OBJECTIVE: To more clearly define the efficiency and potential benefits of variable pulse-width laser technology for ureteroscopic lithotripsy, we performed comparative in vitro evaluations assessing stone comminution, laser fiber tip degradation, and stone retropulsion. METHODS: All experiments were conducted using a Swiss LaserClast Ho: YAG laser (Electro Medical Systems, Nyon, Switzerland) with adjustable pulse duration (300 µs - 1500 µs). To assess comminution efficiency and fiber tip degradation, a "dusting" model was employed; the laser fiber tip was moved by a 3-dimensional positioning system in a spiral motion across a flat BegoStone surface submerged in water...
January 13, 2017: Urology
https://www.readbyqxmd.com/read/28089888/evaluation-of-the-effectiveness-of-a-short-term-treatment-and-repeat-treatment-of-nocturnal-enuresis-using-an-enuresis-alarm
#9
Taiju Hyuga, Shigeru Nakamura, Shina Kawai, Hideo Nakai
OBJECTIVE: To evaluate the effectiveness of a 3-month enuresis alarm (EA) treatment and repeat EA treatment among pediatric patients with nocturnal enuresis (NE), and to compare patient characteristics among 'responders' and 'non-responders' to treatment. MATERIALS AND METHODS: Clinical outcomes were retrospectively evaluated for 137 children (94 boys and 43 girls, mean age, 10.1 years). Effectiveness was evaluated after an initial 3-month treatment, using the International Children's Continence Society criteria...
January 12, 2017: Urology
https://www.readbyqxmd.com/read/28089887/ureteral-stone-diameter-on-computerized-tomography-coronal-reconstructions-is-clinically-important-and-underreported
#10
Mustafa Kadihasanoglu, Tracy Marien, Nicole L Miller
OBJECTIVES: The aim of this study is to compare the maximum stone diameter of ureteral stones in the coronal plane to the axial and determine the clinical significance of the coronal diameter. METHODS: A retrospective chart review was performed on patients seen in clinic between September 2013 and November 2015.Patients were included if they had a history of ureteral stone noted on CT performed with coronal reconstructions. Patients were excluded if they had multiple ureteral stones, history of upper urinary tract abnormalities, need for urgent intervention, or no follow-up...
January 12, 2017: Urology
https://www.readbyqxmd.com/read/28089886/adjuvant-sunitinib-in-high-risk-renal-cell-carcinoma-after-nephrectomy
#11
LETTER
Werner J Struss, Peter C Black
No abstract text is available yet for this article.
January 12, 2017: Urology
https://www.readbyqxmd.com/read/28088556/regulation-of-docetaxel-sensitivity-in-prostate-cancer-cells-by-hsa-mir-125a-3p-via-modulation-of-mta1-signaling
#12
Jian-Zhou Liu, Feng-Yan Yin, Chang-You Yan, Hui Wang, Xiao-Hui Luo
OBJECTIVE: To identify the potential down-stream targets of hsa-miR-125a-3p, a mature form of miR-125a, during the pathogenesis of chemoresistance in prostate cancer (PCa). METHODS: Expression levels of hsa-miR-125a-3p was assessed in chemoresistant PCa tissues and experimentally-established chemoresistant cells using quantitative RT-PCR (qRT-PCR). The effect of hsa-miR-125a-3p knockdown or hsa-miR-125a-3p overexpression on the Dox-induced cell death was evaluated using apoptosis ELISA in chemosensitive PC-3 cells or in chemoresistant PC-3 cells (PC-3R)...
January 11, 2017: Urology
https://www.readbyqxmd.com/read/28088555/injury-in-pelvic-fracture-urethral-injury-is-membrano-bulbar-fact-or-myth
#13
Pankaj M Joshi, Devang J Desai, Darshan Shah, Devashree Joshi, Sanjay B Kulkarni
Pelvic fracture urethral injuries (PFUI) commonly result from motor vehicle collisions. The mechanism of injury conventionally thought was a shearing injury at the membranous urethra, which would destroy the striated sphincter. Continence would therefore depend on the bladder neck. Striated sphincter and site of injury has not been shown clearly on preoperative imaging. We demonstrate a our protocol of performing MRI whereby the membranous sphincter is seen intact and the injury is shown to be at the membrano-bulbar junction contrary to conventional belief...
January 11, 2017: Urology
https://www.readbyqxmd.com/read/28088554/mir-99a-suppresses-proliferation-migration-invasion-and-induces-g1-phase-cell-cycle-arrest-via-targeting-igf-1r-pathway-in-renal-cell-carcinoma-786-0-and-os-rc-2-cells
#14
Bo Hao, Li Cui, Yi Gu, Bo Zhang, Min Wang, Hua Zhou, Renfang Xu, XiaoZhou He
OBJECTIVE: To explore the potential mechanism of microRNA-99a (miR-99a) and IGF-1R (insulin-like growth factor 1 receptor) accounting for RCC. MATERIALS AND METHODS: The RCC 786-O and OS-RC-2 cells were transfected with miR-99a mimics or small interfering RNA (siRNA) that silence the IGF-1R (IGF-1R-siRNA) to upregulate the expression of miR-99a and to downregulate the expression of IGF-1R. Real-time PCR and western-blot were used to detect the expression of proteins...
January 11, 2017: Urology
https://www.readbyqxmd.com/read/28088435/editorial-comment
#15
Jay D Raman
No abstract text is available yet for this article.
January 11, 2017: Urology
https://www.readbyqxmd.com/read/28088434/editorial-comment
#16
Nima Almassi, Howard B Goldman
No abstract text is available yet for this article.
January 11, 2017: Urology
https://www.readbyqxmd.com/read/28088433/author-reply
#17
Takahiro Osawa, Sapan N Ambani, Ted A Skolarus, Todd M Morgan
No abstract text is available yet for this article.
January 11, 2017: Urology
https://www.readbyqxmd.com/read/28088432/detection-of-upper-tract-urothelial-malignancies-by-computed-tomography-urography-in-patients-referred-for-hematuria-at-a-large-tertiary-referral-center
#18
Clayton W Commander, David C Johnson, Mathew C Raynor, Lauren M Burke, Kathryn E Hacker, Bryan Hoag, Julia R Fielding, Richard C Semelka, Ellie R Lee
OBJECTIVE: To evaluate the age-stratified prevalence of upper tract urothelial malignancies diagnosed on computed tomography urography in a large cohort of patients referred for initial evaluation of hematuria. MATERIALS AND METHODS: A total of 1123 consecutive adults without a history of urothelial cancer underwent initial computed tomography urography for gross hematuria (n = 652), microscopic hematuria (n = 457), or unspecified hematuria (n = 14) at a single institution from October 2006 to October 2012...
January 11, 2017: Urology
https://www.readbyqxmd.com/read/28088431/reply
#19
Clayton W Commander, David C Johnson, Mathew C Raynor
No abstract text is available yet for this article.
January 11, 2017: Urology
https://www.readbyqxmd.com/read/28087281/mtuepa-trans-urethral-monopolar-enucleation-of-prostatic-adenoma-preliminary-report
#20
Vito Pansadoro, Paolo Emiliozzi, Gianluca Del Vecchio, Marco Martini, Paolo Scarpone, Francesco Del Giudice, Domenico Veneziano, Aldo Brassetti, Christophe Assenmacher
OBJECTIVES: To describe preliminary results of our monopolar Transurethral Enucleation of Prostatic Adenoma (mTUEPA). METHODS: A consecutive series of patient treated with mTUEPA, a retrograde enucleation of the prostatic adenoma performed by means of a standard monopolar resectoscope, were prospectively enrolled. Symptoms, uroflometry parmeters and post voiding residual (PVR) were assessed at baseline and 1, 6 and 12 months post-operatively. Prostate volume (PV) was evaluated at baseline by means of transrectal ultrasound...
January 10, 2017: Urology
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