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Urology

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https://www.readbyqxmd.com/read/28438629/the-impact-of-multiple-prostate-biopsies-on-risk-for-major-complications-following-radical-prostatectomy-a-population-based-cohort-study
#1
Daniel Olvera-Posada, Blayne Welk, J Andrew McClure, Jennifer Winick-Ng, Jonathan I Izawa, Stephen E Pautler
OBJECTIVE: To evaluate the impact of multiple transrectal ultrasound-guided prostate biopsies (TRUS-Bx) before radical prostatectomy (RP) on surgical outcomes. METHODS: Administrative databases were used to identify all patients who had a RP performed in the province of Ontario from April 1, 2002 to March 31, 2013. TRUS-Bx prior to RP were identified and patients were categorized as having one or more than one prior TRUS-Bx. The primary end point was a composite index of serious surgical complications...
April 21, 2017: Urology
https://www.readbyqxmd.com/read/28438628/diagnostic-accuracy-of-64-cu-psma-pet-ct-for-primary-lymph-node-staging-of-intermediate-to-high-risk-prostate-cancer-our-preliminary-experience
#2
Francesco Cantiello, Vincenzo Gangemi, Giuseppe Lucio Cascini, Ferdinando Calabria, Marco Moschini, Matteo Ferro, Gennaro Musi, Salvatore Butticè, Andrea Salonia, Alberto Briganti, Rocco Damiano
OBJECTIVE: To assess the diagnostic accuracy of (64)Copper Prostate-Specific Membrane Antigen ((64)Cu PSMA) positron emission tomography/computed tomography (PET/CT) in the primary lymph node (LN) staging of a selected cohort of intermediate-high risk Prostate Cancer (PCa) patients. MATERIALS AND METHODS: An observational prospective study was performed in 23 patients with intermediate-high risk PCa, who underwent (64)Cu-PSMA PET/CT for local and lymph nodal staging before laparoscopic radical prostatectomy (LRP) with an extended pelvic LN dissection...
April 21, 2017: Urology
https://www.readbyqxmd.com/read/28438627/atypical-small-acinar-proliferation-and-high-grade-prostatic-intraepithelial-neoplasia-in-the-era-of-multi-parametric-mri-a-contemporary-review
#3
REVIEW
Todd G Manning, Ernest Cheung, Marlon Perera, Daniel Christidis, Jonathan S O'Brien, Catherine Mitchell, Damien M Bolton, Nathan Lawrentschuk
Multiparametric Magnetic Resonance Imaging (mpMRI) has added to the armamentarium for the diagnosis and surveillance for organ confined prostate cancer. Atypical small acinar proliferation (ASAP) and high-grade prostatic intraepithelial neoplasia (HGPIN) are premalignant prostatic lesions. The management of such lesions remains contentious, and the addition of mpMRI introduces further uncertainty given its ability to pick up indolent lesions and its use in targeted biopsy. We aimed to perform a comprehensive review of current evidence regarding ASAP, HGPIN and mpMRI to ascertain a consensus for a current management algorithm...
April 21, 2017: Urology
https://www.readbyqxmd.com/read/28438626/near-infrared-intraoperative-molecular-imaging-can-identify-metastatic-lymph-nodes-in-prostate-cancer
#4
Leilei Xia, Ryan Zeh, Jack Mizelle, Andrew Newton, Jarrod Predina, Shuming Nie, Sunil Singhal, Thomas J Guzzo
OBJECTIVE: To propose a novel method to perform indocyanine green (ICG) based near-infrared (NIR) fluorescence imaging during pelvic lymph node dissection (PLND) for prostate cancer patients with lymph node metastasis (LNM). MATERIALS AND METHODS: A prostate cancer cell line PC3 was used to establish xenograft model in NOD/SCID mouse. After tumor growth, mice were injected through the tail vein with ICG. Xenografts and surrounding tissues were imaged with NIR camera 24 hours after intravenous ICG and tumor-to-background ratios (TBRs) were calculated...
April 21, 2017: Urology
https://www.readbyqxmd.com/read/28438625/laser-endopyelotomy-in-the-management-of-pelvi-ureteric-junction-obstruction-in-adults-a-systematic-review-of-the-literature
#5
REVIEW
Muhammad Elmussareh, Oliver Traxer, Bhaskar Kumar Somani, Chandra Shekhar Biyani
Laser endopyelotomy (LEP) is considered as an option to treatment of pelvi-ureteric junction obstruction (PUJO) in adults. A comprehensive systematic search of the published literature was performed to assess the success rate and peri-operative complications of LEP in the treatment of primary and secondary PUJO and identify the factors that may impact of the success of LEP. The evidence available has significant limitations with heterogeneous study design and definitions of outcomes. The average overall success rate of the pooled data was 75% with a mean follow-up of 29 months...
April 21, 2017: Urology
https://www.readbyqxmd.com/read/28438624/bladder-recurrence-of-clear-cell-sarcoma-of-the-kidney-7-years-after-initial-presentation
#6
John Weaver, Tammy Ho, Adam Lang, Joel F Koenig, Douglas E Coplen, Louis Dehner, Erica J Traxel
Clear cell sarcoma of the kidney (CCSK) is the second most common pediatric renal malignancy after Wilms tumor. CCSK has the potential to metastasize to distant sites and was historically known as the bone metastasizing renal tumor. We report an exceedingly rare case of a bladder recurrence of CCSK. Our patient presented with gross hematuria 7 years after initial complete response. He was found to have a large sessile bladder tumor and underwent a partial cystectomy with right pelvic lymph node dissection. Final pathology was metastatic CCSK...
April 21, 2017: Urology
https://www.readbyqxmd.com/read/28438403/editorial-comment
#7
Faysal A Yafi
No abstract text is available yet for this article.
April 21, 2017: Urology
https://www.readbyqxmd.com/read/28435035/the-expanding-role-of-advanced-practice-providers-in-urologic-procedural-care
#8
Joshua P Langston, Richard Duszak, Venetia L Orcutt, Heather Schultz, Brad Hornberger, Lawrence C Jenkins, Jennifer Hemingway, Danny R Hughes, Raj S Pruthi, Matthew E Nielsen
OBJECTIVE: To understand the role of Advanced Practice Providers (APPs) in urologic procedural care, and its change over time. As the population ages and the urologic workforce struggles to meet patient access demands, the role of APPs in the provision of all aspects of urologic care is increasing. However, little is currently known about their role in procedural care. MATERIALS AND METHODS: Commonly performed urologic procedures were linked to Current Procedural Terminology (CPT) codes from 1994 to 2012...
April 20, 2017: Urology
https://www.readbyqxmd.com/read/28435034/cytoreductive-prostatectomy-for-metastatic-prostate-cancer-first-lessons-learned-from-the-multicentric-prospective-lomp-trial
#9
Filip Poelaert, Caroline Verbaeys, Bernard Rappe, Bart Kimpe, Ignace Billiet, Hendrik Plancke, Karel Decaestecker, Valérie Fonteyne, Sarah Buelens, Nicolaas Lumen
OBJECTIVE: To prospectively evaluate patients with newly diagnosed metastatic prostate cancer (mPCa) in the context of the LoMP trial (which investigates the role of cytoreductive radical prostatectomy [cRP] in addition to standard of care [SoC]). To provide a preliminary analysis of patient's characteristics, safety of cRP and early local symptoms. PATIENTS AND METHODS: cRP was performed in asymptomatic patients with a resectable tumor and fit to undergo surgery (group A, n=17)...
April 20, 2017: Urology
https://www.readbyqxmd.com/read/28435033/could-reduced-fluid-intake-cause-the-placebo-effect-seen-in-overactive-bladder-clinical-trials-analysis-of-a-large-solifenacin-integrated-database
#10
Sender Herschorn, Christopher R Chapple, Robert Snijder, Emad Siddiqui, Linda Cardozo
OBJECTIVE To assess the hypothesis that patients receiving placebo in overactive bladder (OAB) trials who experience less benefit from 'treatment' continue with behavioral modifications such as fluid restriction, whereas those on active treatment adopt more normal drinking patterns. This may manifest itself as a reduction in micturition frequency (MF). MATERIALS AND METHODS We interrogated a large integrated database containing pooled patient data from 4 randomized, placebo-controlled phase III OAB solifenacin studies...
April 20, 2017: Urology
https://www.readbyqxmd.com/read/28435032/clinical-efficacy-of-1-year-intensive-systematic-dietary-manipulation-as-complementary-and-alternative-medicine-therapies-on-female-interstitial-cystitis-bladder-pain-syndrome-patients
#11
Hitoshi Oh-Oka
OBJECTIVE: To evaluate the clinical efficacy of intensive systematic dietary manipulation (ISDM) for female patients with interstitial cystitis (IC)/bladder pain syndrome (BPS) in stable condition who were followed in our hospital. MATERIALS AND METHODS: In cooperation with the nutrition control team, we created a basic IC/BPS diet menu for 1 month. Data regarding daily food intake and food-related symptoms were collected by detailed interview of each patient, we set meal menu to control IC/BPS symptoms and advised the patients to reduce the intake of specific food items to the maximum possible extent...
April 20, 2017: Urology
https://www.readbyqxmd.com/read/28433381/editorial-comment
#12
Ronald W Lewis
No abstract text is available yet for this article.
April 19, 2017: Urology
https://www.readbyqxmd.com/read/28433380/author-reply
#13
Fabio Pezzoni, Fabrizio Ildefonso Scroppo, Giorgio Cavallini
No abstract text is available yet for this article.
April 19, 2017: Urology
https://www.readbyqxmd.com/read/28431996/comparison-of-silodosin-monotherapy-versus-silodosin-with-tadalafil-add-on-therapy-in-patients-with-benign-prostatic-hyperplasia
#14
Takashi Yoshida, Hidefumi Kinoshita, Seiji Shimada, Makoto Taguchi, Tadashi Matsuda
OBJECTIVE: To evaluate the efficacy and safety of add-on therapy with the phosphodiesterase type 5 inhibitor tadalafil for patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia (LUTS/BPH) treated with the α1-adrenoceptor blocker silodosin. METHODS: We analyzed 103 patients with LUTS/BPH with an International Prostate Symptom Score (IPSS) of >8 after ≥4 weeks of silodosin treatment from April 2016 through December 2016 at Kori Hospital...
April 18, 2017: Urology
https://www.readbyqxmd.com/read/28431995/robot-assisted-laparoscopic-urachal-excision-in-children
#15
Haris Ahmed, Adam S Howe, Lori L Dyer, Ronnie G Fine, Jordan S Gitlin, Richard N Schlussel, Paul F Zelkovic, Lane S Palmer
OBJECTIVE: To report the first exclusively pediatric series of robot-assisted urachal remnant excisions in children. MATERIALS & METHODS: We reviewed the medical records of all children who underwent robot-assisted excision of urachal remnants from 2010 to 2016. For the procedure, a 3-port approach was performed in all cases. Excision of the urachus was performed, along with partial cystectomy if there was clear or suspected bladder involvement. Outcomes and complications were reviewed...
April 18, 2017: Urology
https://www.readbyqxmd.com/read/28431994/raynaud-s-phenomenon-revisiting-a-rare-sign-of-pheochromocytoma-paraganglioma
#16
Virendra Ashokrao Patil, Rajiv Kasaliwal, Manjunath R Goroshi, Anurag R Lila, Tushar Bandgar, Nalini S Shah
Paraganglioma (PGL) are rare tumors arising from extraadrenal chromaffin cells and occasionally secret catecholamines. The patient commonly presents with headache, palpitation, anxiety, diaphoresis and episodic or sustained hypertension. Rarely patient can present with Raynaud's phenomenon. We present a case of adolescent girl who presented with isolated Raynaud's phenomenon as only manifestation of metastasis of PGL three years after undergoing surgical excision of normetanephrine secreting abdominal PGL.
April 18, 2017: Urology
https://www.readbyqxmd.com/read/28431993/re-examining-psa-density-defining-the-optimal-psa-range-and-patients-for-using-psa-density-to-predict-prostate-cancer-using-extended-template-biopsy
#17
Joshua Stephen Jue, Marcelo Panizzutti Barboza, Nachiketh Soodana Prakash, Vivek Venkatramani, Varsha R Sinha, Nicola Pavan, Bruno Nahar, Pratik Kanabur, Michael Ahdoot, Yan Dong, Ramgopal Satyanarayana, Dipen J Parekh, Sanoj Punnen
OBJECTIVES: To compare the predictive accuracy of PSA density versus PSA across different PSA ranges and by prior biopsy status in a prospective cohort undergoing prostate biopsy. METHODS: Men from a prospective trial underwent an extended template biopsy to evaluate for prostate cancer at 26 sites throughout the US. The area under the receiver operating curve assessed the predictive accuracy of PSA density versus PSA across three PSA ranges (<4, 4-10, >10 ng/mL)...
April 18, 2017: Urology
https://www.readbyqxmd.com/read/28416299/malignant-mesothelioma-of-the-tunica-vaginalis-testis-outcomes-following-surgical-management-beyond-radical-orchiectomy
#18
Pedro Recabal, Barak Rosenzweig, Wassim M Bazzi, Brett S Carver, Joel Sheinfeld
OBJECTIVE: To describe clinical management and outcomes of a cohort of patients with malignant mesothelioma of the tunica vaginalis testis (MMTVT) who received treatments beyond radical orchiectomy. METHODS: Patients with confirmed MMTVT at a single tertiary-care institution were identified. Treatments, pathologic outcomes, and survival were recorded. Prognostic variables associated with survival were analyzed with a Cox proportional hazards model and Kaplan-Meier curves...
April 14, 2017: Urology
https://www.readbyqxmd.com/read/28412335/metabolic-syndrome-does-not-increase-the-risk-of-ejaculatory-dysfunction-in-patients-with-lower-urinary-tract-symptoms-and-benign-prostatic-enlargement-an-italian-single-center-cohort-study
#19
Cosimo De Nunzio, Riccardo Lombardo, Mauro Gacci, Antonio Nacchia, Fabrizio Presicce, Hassan Alkhatatbeh, Sergio Serni, Andrea Tubaro
OBJECTIVES: To evaluate the relationship between metabolic syndrome and ejaculatory dysfunction in patients with lower urinary tract symptoms (LUTS) and benign prostatic enlargement (BPE). METHODS: From 2012 to 2016, a consecutive series of men with LUTS and BPE attending our prostate clinic, evaluated with the International Prostatic Symptoms Score (IPSS) were enrolled into a prospective database. All patients were assessed using the short form of the International Index of Erectile Function (IIEF-SF) and the male sexual health questionnaire ejaculatory dysfunction short form (MSHQ-ejd-SF) which evaluates the ability to ejaculate, the ejaculation force, the ejaculation volume and subjective bother associated with ejaculatory dysfunction...
April 13, 2017: Urology
https://www.readbyqxmd.com/read/28412334/ovotestis-in-adolescence-two-case-reports
#20
Jyoti D Chouhan, David I Chu, Antoinette Birs, Louise C Pyle, Jason P Van Batavia, Rebecca L Linn, Susan J Back, Pierre Russo, Kassa Darge, Thomas F Kolon, Arun K Srinivasan
We present two patients found to have ovotesticular disorder of sexual differentiation (otDSD) in late adolescence. Two 15-year-old phenotypically male patients presented to a large pediatric hospital with different complaints: one with concern for testicular rupture after a straddle injury; the other with gynecomastia. Further work-up, including imaging and lab tests, was performed before surgical exploration. The first patient had unilateral ovotestis, contralateral testis, and SRY-negative 46,XX karyotype...
April 13, 2017: Urology
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