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Urology

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https://www.readbyqxmd.com/read/29339111/stem-cells-for-urinary-incontinence-functional-differentiation-or-cytokine-effects
#1
REVIEW
Bradley C Gill, Daniel Z Sun, Margot S Damaser
Minimally-invasive stem cell therapy for stress urinary incontinence may provide an effective nonsurgical treatment for this common condition. Clinical trials of periurethral stem cell injection have been underway and basic science research has demonstrated the efficacy of both local and systemic stem cell therapies. Results differ as to whether stem cells have a therapeutic effect by differentiating into permanent, functional tissues, or whether they exert benefits through a transient presence and the secretion of regenerative factors...
January 12, 2018: Urology
https://www.readbyqxmd.com/read/29338948/editorial-comment
#2
Craig V Comiter
No abstract text is available yet for this article.
January 12, 2018: Urology
https://www.readbyqxmd.com/read/29338947/reply
#3
Nicholas J Waler, Raul I Clavijo, Ranjith Ramasamy
No abstract text is available yet for this article.
January 12, 2018: Urology
https://www.readbyqxmd.com/read/29338946/author-reply
#4
Carrie Stewart, Wayne J G Hellstrom
No abstract text is available yet for this article.
January 12, 2018: Urology
https://www.readbyqxmd.com/read/29338945/editorial-comment
#5
Edmund Sabanegh
No abstract text is available yet for this article.
January 12, 2018: Urology
https://www.readbyqxmd.com/read/29331567/author-reply
#6
Rena D Malik, Yuefeng Rose Wu, Alana L Christie, Feras Alhalabi, Philippe E Zimmern
No abstract text is available yet for this article.
January 10, 2018: Urology
https://www.readbyqxmd.com/read/29331566/editorial-comment
#7
Deborah J Lightner
No abstract text is available yet for this article.
January 10, 2018: Urology
https://www.readbyqxmd.com/read/29331304/gender-representation-in-urological-subspecialties
#8
Oluwarotimi S Nettey, Joceline S Fuchs, Stephanie J Kielb, Edward M Schaeffer
OBJECTIVE: To examine associations between urologic subspecialization, surgeon gender and practice patterns among certifying urologists over the last 13 years. MATERIALS AND METHODS: Demographic data of certifying and recertifying urologists (2004 to 2015) was obtained from the American Board of Urology (ABU). We investigated gender-specific trends in self-reported practice type (academic practice, private practice), subspecialization, and employment as a full-time versus part-time physician, relative to certification year and cycle...
January 10, 2018: Urology
https://www.readbyqxmd.com/read/29330001/in-bore-3-0-t-magnetic-resonance-imaging-guided-transrectal-targeted-prostate-biopsy-in-a-repeat-biopsy-population-diagnostic-performance-complications-and-learning-curve
#9
Alexander Friedl, Jenifer Schneeweiss, Sabina Sevcenco, Klaus Eredics, Thomas Kunit, Martin Susani, Danijel Kivaranovic, Edith Eisenhuber-Stadler, Lukas Lusuardi, Clemens Brössner, Wolfgang Schima
OBJECTIVE: To evaluate the diagnostic performance and complication rate of the in-bore magnetic resonance imaging-guided transrectal targeted prostate biopsy (MRGB) in a repeat biopsy population on basis of a nearly four year learning curve (2014-2017). MATERIALS AND METHODS: A total of 142 consecutive males with a history of previous biopsies and persistent suspicion of prostate cancer (PCa) due to prostate specific antigen (PSA) elevation initially underwent MRGB in the case of prostate imaging reporting and data system (PI-RADS) 3-5 lesions...
January 9, 2018: Urology
https://www.readbyqxmd.com/read/29330000/histotripsy-treatment-of-benign-prostatic-enlargement-using-the-vortx-rx-system-initial-human-safety-and-efficacy-outcomes
#10
T G Schuster, J T Wei, K Hendlin, R Jahnke, W W Roberts
OBJECTIVES: To assess clinical safety (primary) and efficacy (secondary) of histotripsy for treatment of symptomatic benign prostatic enlargement (BPE) in a first-in human study. METHODS: Twenty-five male subjects with moderate to severe lower urinary tract symptoms (LUTS), prostate size between 30 and 80 grams and no evidence of prostate cancer were enrolled at two sites in a prospective, single-arm study. Treatment consisted of acoustic energy delivery through the perineum with integrated real-time TRUS monitoring using the Vortx RX system...
January 9, 2018: Urology
https://www.readbyqxmd.com/read/29309798/impact-of-adjuvant-radiation-on-artificial-urinary-sphincter-durability-in-post-prostatectomy-patients
#11
Arnav Srivastava, Gregory A Joice, Hiten D Patel, Madeleine G Manka, Nikolai A Sopko, E James Wright
OBJECTIVES: To further understand the implications of adjuvant radiation on artificial urinary sphincter durability (AUS) in post-prostatectomy patients. METHODS: 158 post-prostatectomy patients, identified by retrospective chart review, underwent AUS placement by one surgeon from 2008 - 2016. Time-to-event analysis measured the effect of adjuvant radiation on all-cause failure and competing risks regression stratified failure by cause (infection/erosion, urethral atrophy, mechanical failure)...
January 5, 2018: Urology
https://www.readbyqxmd.com/read/29307733/safety-and-feasibility-of-intravesical-instillation-of-botulinum-toxin-a-in-hydrogel-based-slow-release-delivery-system-in-interstitial-cystitis-bladder-pain-syndrome-patients-a-pilot-study
#12
Yishai H Rappaport, Amnon Zisman, Michal Jeshurun-Gutshtat, Tami Gerassi, Gil Hakim, Yuri Vinshtok, Kobi Stav
OBJECTIVE: To assess feasibility and safety of a mixture instillation of TC-3 Gel, a novel reverse-thermal gelation hydrogel, and botulinum toxin-A (BTX-A) for the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS). TC-3 Gel/BTX-A mix is instilled into the bladder as liquid, solidifies due to body heat and gradually dissolves to release BTX-A for several hours. METHODS: A single intravesical instillation of 200U BTX-A premixed with 40ml TC-3 Gel was delivered to the bladder...
January 4, 2018: Urology
https://www.readbyqxmd.com/read/29307732/promescent%C3%A2-has-a-cytotoxic-impact-on-fresh-human-sperm-in-vitro
#13
Melissa Sutton, Caitlin Hunn, Roxanne B Summers-Colquitt, Shu-Hung Chen, Shahryar K Kavoussi, Keikhosrow M Kavoussi, Parviz K Kavoussi
OBJECTIVES: To assess the impact of Promescent®, a commonly used topical medication for premature ejaculation (PE), on human sperm motility, forward progression (FP), viability, and sperm DNA fragmentation (SDF) in vitro. METHODS: Aliquots from specimens for diagnostic semen analyses from patients (n=20) presenting to a couple's fertility center andrology laboratory for fertility testing were included after the full diagnostic semen analyses were performed. Samples which met the World Health Organization (WHO) 5th edition criteria as "normal" had Promescent® applied to an aliquot of the sample and motility, FP, viability, and SDF were compared to an aliquot which was not treated with Promescent®...
January 4, 2018: Urology
https://www.readbyqxmd.com/read/29305945/urosymphyseal-fistulas-resulting-from-endoscopic-treatment-of-radiation-induced-posterior-urethral-strictures
#14
Daniel D Shapiro, David C Goodspeed, Wade Bushman
Objective To describe the inciting events leading to urosymphyseal fistulas (UF) and pubic osteomyelitis (PO) in patients who had radiation induced urethral strictures. Materials and Methods We retrospectively reviewed patients who underwent simultaneous pubic debridement, simple cystectomy and urinary diversion for refractory UF and PO from 2014-2016. We investigated inciting events leading to UF as well as patient presenting symptoms, diagnosis, management, and outcomes. Results Five patients were identified over a two-year period...
January 3, 2018: Urology
https://www.readbyqxmd.com/read/29305944/expression-of-zmynd15-in-testes-of-azoospermic-men-and-association-with-sperm-retrieval
#15
Motahare-Sadat Hashemi, Hossein Mozdarani, Kamran Ghaedi, Mohammad Hossein Nasr-Esfahani
OBJECTIVE: To compare the expression levels of ZMYND15 and its target haploid genes (TNP1, PRM1and SPEM1) in testicular samples of non-obstructive azoospermia (NOA) vs. obstructive azoospermia (OA). The level of these transcripts were also compared in azoospermic samples with positive and negative sperm retrieval (SR). METHODS: This study included 63 testis biopsy samples from 16 OA and 47 NOA individuals. Expression levels of these target genes were determined by real-time reverse transcription-polymerase chain reaction using ΔΔCt method...
January 3, 2018: Urology
https://www.readbyqxmd.com/read/29305943/pediatric-testicular-hemangioma-in-a-10-year-old-a-rare-entity-that-may-mimic-malignancy-with-appraisal-of-the-literature
#16
Sarah B Hugar, Brian Kadow, Amy Davis, Sarangarajan Ranganathan, Miguel Reyes-Múgica, Francis X Schneck, Jennifer Picarsic
Capillary hemangioma is a rare benign lesion in the testicle, particularly in pediatrics. It can mimic malignancy, leading to radical orchiectomy. We present a case of a testicular hemangioma in a child, and review the literature on testicular hemangiomas in this age group. A hypervascular testicular lesion without elevated tumor markers may warrant intraoperative biopsy to direct surgical management, which may include testis-sparing surgery if amenable.
January 3, 2018: Urology
https://www.readbyqxmd.com/read/29305942/a-delayed-appearance-of-the-secondary-bladder-stone-10-years-after-tension-free-vaginal-tape-procedure
#17
Hao-Wei Chen, Yu-Chen Chen, Yii-Her Chou
Bladder calculi occur in female is uncommon and the evaluation of bladder stone in women with any history of previous pelvic surgery demands careful attention. Bladder erosion due to previous anti-incontinence surgery formed the nidus for stone formation, and often presented as recurrent cystitis or refractory urinary incontinence since the early postoperative period. We hereby reported a rarely delayed appearance of the symptomatic iatrogenic bladder stone occurred 10 years after previous tension-free vaginal tape procedure...
January 3, 2018: Urology
https://www.readbyqxmd.com/read/29305941/traumatic-urethraggia-in-adolescence-ushering-in-the-new-age-of-extreme-sports
#18
I Hodge, A Adam, M Chennapragada, A Tiu, A V Deshpande
Herein we describe a case of a 14-year-old with straddle injury to the base of the penis, sustained during an indoor rock climbing accident, who presented with severe urethrragia. Urethral injury was confirmed with retrograde urethrography. The patient became haemodynamically unstable from persistent blood loss, and corporal arterial injury was diagnosed on CT angiography. The urethraggia was successfully controlled with angioembolisation. The unique aspects of this case were the challenges in establishing the diagnosis on the background of the abnormal presentation of vascular injury of blood loss as opposed to painless priapism...
January 3, 2018: Urology
https://www.readbyqxmd.com/read/29305940/complications-and-outcomes-of-pregnancy-and-cesarean-delivery-in-women-with-neuropathic-bladder-and-lower-urinary-tract-reconstruction
#19
Joshua D Roth, Jessica T Casey, Benjamin M Whittam, Konrad M Szymanski, Martin Kaefer, Richard C Rink, Frank P Schubert, Mark P Cain, Rosalia Misseri
Objective To determine the outcomes of pregnancy and cesarean delivery (CD) delivery in women with neuropathic bladder (NB) and pediatric lower urinary tract reconstruction (LUTR) as these women often have normal fertility and may become pregnant. Methods We reviewed consecutive patients from July 2001 to June 2016 with NB due to spinal dysphraphism who underwent LUTR, became pregnant, and had a CD at our institution. We collected data on demographics, hydronephrosis, symptomatic urinary tract infection (UTI), continence and catheterization during pregnancy...
January 3, 2018: Urology
https://www.readbyqxmd.com/read/29305205/associations-between-travel-distance-hospital-volume-and-outcomes-following-radical-cystectomy-in-patients-with-muscle-invasive-bladder-cancer
#20
Leilei Xia, Benjamin L Taylor, Ronac Mamtani, John P Christodouleas, Thomas J Guzzo
OBJECTIVE: To explore the associations between travel distance, hospital volume, and outcomes following radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC) METHODS: The 2006 to 2013 National Cancer Database (NCDB) was queried to identify patients with MIBC who underwent RC. Multivariable regressions alternately including travel distance, hospital volume, and both in the models were used. Travel distances and hospital volumes were categorized by quartiles. Outcomes of interest were overall survival and quality-of-care indicators...
January 2, 2018: Urology
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