A difficult-to-treat pleuropulmonary histoplasmosis in a patient with rheumatoid arthritis in Taiwan.

Wen-Kai Chu, Un-In Wu, Tai-Fen Lee, Aristine Cheng, Kai-Hsiang Chen, Kuan-Yin Lin, Yee-Chun Chen

Journal of Microbiology Immunology and Infection 2023 Februrary

Amphotericin B and itraconazole are the primary agents for treating histoplasmosis. Newer azoles are alternatives for patients refractory to or intolerant of standard therapy. We report an 83-year-old woman with rheumatoid arthritis complicated with pleuropulmonary histoplasmosis who responded to liposomal amphotericin B, but progressed under voriconazole and posaconazole maintenance therapy.

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