The 2019-2020 Dengue Fever Epidemic: Genomic Markers Indicating Severity in Dominican Republic Children.

Brittany N Simpson, Miguel E Mejía Sang, Yonairy Collado Puello, Elvira J Diaz Brockmans, María F Díaz Soto, Stephanie M Rivera Defilló, Karla M Taveras Cruz, Javier O Santiago Pérez, Ammar Husami, Melissa E Day, Valentina Pilipenko, Rafael Mena, Cesár Mota, Margaret K Hostetter, Louis J Muglia, Elizabeth Schlaudecker, Javier Gonzalez Del Rey, Lisa J Martin, Carlos E Prada

Journal of the Pediatric Infectious Diseases Society 2023 April 19

We performed an observational cohort study to assess associations between genetic factors of dengue fever (DF) severity in children in the Dominican Republic. A total of 488 participants had serologically confirmed DF. We replicated the association between the IFIH1 gene (rs1990760) and severe DF (n = 80/488, p = 0.006) and identified novel associations needing further investigation.

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