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Journal of the Pediatric Infectious Diseases Society

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https://www.readbyqxmd.com/read/28093452/a-time-to-save
#1
Carol J Baker
Group B Streptococcus (GBS), characterized by Lancefield in 1933, was not recognized as a human pathogen until the early 1970s when it emerged and replaced Escherichia coli as the most common cause of sepsis and meningitis among neonates and young infants. This article briefly gives a personnel account of the discovery of clinical syndromes of GBS distinguished by age at onset, vertical mode of transmission for early-onset disease, meningeal tropism for GBS capsular (CPS) type III strains, and protective CPS epitopes...
January 16, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28073985/population-based-pertussis-incidence-and-risk-factors-in-infants-less-than-6-months-in-nepal
#2
Michelle M Hughes, Janet A Englund, Jane Kuypers, James M Tielsch, Subarna K Khatry, Laxman Shrestha, Steven C LeClerq, Mark Steinhoff, Joanne Katz
BACKGROUND: Pertussis is estimated to cause 2 percent of childhood deaths globally and is a growing public health problem in developed countries despite high vaccination coverage. Infants are at greatest risk of morbidity and mortality. Maternal vaccination during pregnancy may be effective to prevent pertussis in young infants, but population-based estimates of disease burden in infants are lacking, particularly in low-income countries. The objective of this study was to estimate the incidence of pertussis in infants less than 6 months of age in Sarlahi District, Nepal...
January 10, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28064237/response-to-effectiveness-of-the-10-valent-pneumococcal-nontypeable-haemophilus-influenzae-protein-d-conjugated-vaccine-phid-cv-against-carriage-and-acute-otitis-media-a-double-blind-randomized-clinical-trial-in-finland
#3
LETTER
Heather L Sings, Raul Isturiz
No abstract text is available yet for this article.
January 7, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28062554/prediction-of-resistance-to-intravenous-immunoglobulin-in-children-with-kawasaki-disease
#4
Maskit Bar-Meir, Itai Kalisky, Andrei Schwartz, Eli Somekh, Diana Tasher
BACKGROUND: Approximately 10%-20% of patients with Kawasaki disease (KD) are refractory to initial intravenous immunoglobulin (IVIg) therapy, and these "nonresponders" are at higher risk of coronary artery abnormalities. Early identification of these patients, who may benefit from additional therapy, is challenging. The aim of the present study is to identify predictors for IVIg resistance. METHODS: We reviewed clinical records of 312 consecutive KD patients from 9 medical centers in Israel (development dataset) and 186 patients from additional 5 centers (validation dataset)...
January 6, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28062553/neurobrucellosis-unexpected-answer-from-metagenomic-next-generation-sequencing
#5
Kanokporn Mongkolrattanothai, Samia N Naccache, Jeffrey M Bender, Erik Samayoa, Elizabeth Pham, Guixia Yu, Jennifer Dien Bard, Steve Miller, Grace Aldrovandi, Charles Y Chiu
A diagnosis of brucellosis can be difficult because routine culture and serological methods exhibit variable sensitivity and specificity. We present the use of a metagenomic next- generation sequencing assay to diagnose a case of neurobrucellosis from cerebrospinal fluid, resulting in the institution of appropriate antibiotic treatment and a favorable clinical outcome.
January 6, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28062552/time-to-change-dosing-of-inactivated-quadrivalent-influenza-vaccine-in-young-children-evidence-from-a-phase-iii-randomized-controlled-trial
#6
Varsha K Jain, Joseph B Domachowske, Long Wang, Opokua Ofori-Anyinam, Miguel A Rodríguez-Weber, Michael L Leonardi, Nicola P Klein, Gary Schlichter, Robert Jeanfreau, Byron L Haney, Laurence Chu, Jo-Ann S Harris, Kwabena O Sarpong, Amanda C Micucio, Jyoti Soni, Vijayalakshmi Chandrasekaran, Ping Li, Bruce L Innis
BACKGROUND: Children under 3 years of age may benefit from a double-dose of inactivated quadrivalent influenza vaccine (IIV4) instead of the standard-dose. METHODS: We compared the only United States-licensed standard-dose IIV4 (0.25 mL, 7.5 µg hemagglutinin per influenza strain) versus double-dose IIV4 manufactured by a different process (0.5 mL, 15 µg per strain) in a phase III, randomized, observer-blind trial in children 6-35 months of age (NCT02242643). The primary objective was to demonstrate immunogenic noninferiority of the double-dose for all vaccine strains 28 days after last vaccination...
January 6, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28040689/burden-of-healthcare-associated-viral-respiratory-infections-in-children-s-hospitals
#7
Caroline Quach, Rita Shah, Lorry G Rubin
OBJECTIVE: Although healthcare-associated (HA) viral respiratory infections (VRIs) are common in pediatrics, no benchmark for comparison exists. We aimed to determine, compare, and assess determinants of unit-specific HA-VRI incidence rates in 2 children's hospitals. METHODS: This study was a retrospective comparison of prospective cohorts. The Montreal Children's Hospital and the Cohen Children's Medical Center of New York perform prospective surveillance for HA-VRI using standardized definitions that require the presence of symptoms compatible with VRI and virus detection...
December 30, 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28040688/prevalence-of-pertussis-antibodies-in-maternal-blood-cord-serum-and-infants-from-mothers-with-and-those-without-tdap-booster-vaccination-during-pregnancy-in-argentina
#8
Aurelia A Fallo, Silvina E Neyro, Gabriela V Manonelles, Claudia Lara, Daniela Hozbor, Jonathan Zintgraff, Silvina Mazzeo, Héctor E Davison, Susana González, Estella Zapulla, Oscar Canle, Miguel Huespe, Marcelo Galas, Eduardo L López
BACKGROUND: Morbidity and mortality rates for pertussis in infants are high because disease often occurs before the onset of routine immunization or in those who do not complete a primary immunization series. Pertussis immunization is recommended during pregnancy to achieve antibody levels sufficient to protect young infants. To our knowledge, no previous reports of maternal pertussis immunization results in Latin America exist in the literature. METHODS: This study compared pertussis antibody levels in newborns from mothers who received or did not receive a tetanus-diphtheria-acellular pertussis vaccination (TdapV) during pregnancy...
December 30, 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/27988496/resurgence-of-rotavirus-genotype-g12-in-st-louis-during-the-2014-2015-rotavirus-season
#9
Kristine M Wylie, Katherine M Stanley, Erin McElvania TeKippe, Kusal Mihindukulasuriya, Gregory A Storch
BACKGROUND: Rotaviruses are a leading cause of gastroenteritis. Rotavirus vaccination has dramatically reduced rotavirus occurrence; however, we have noticed mild to moderate recurrences in the St. Louis area in alternate years. In 2013, we found rotavirus genotype G12 to be the dominant strain in the St. Louis region. In this study, we again determined the distribution of genotypes and ascertained vaccine history in patients infected with rotavirus G12 during the 2014-15 season. METHODS: Samples submitted to the St...
December 17, 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/27988495/aeromonas-as-a-cause-of-purulent-folliculitis-a-case-report-and-review-of-the-literature
#10
Aleksandra E Olszewski, Manjiree V Karandikar, Neeraj K Surana
Aeromonas species are rarely an identified cause of folliculitis. Here, we describe the case of a patient who had purulent folliculitis of the breast caused by an Aeromonas species and review 4 other cases presented in the literature, highlighting the commonalities observed. Aeromonas infection should be considered in patients who present with purulent folliculitis, particularly those with exposure to nonchlorinated pools or baths.
December 16, 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/27856730/multidrug-and-carbapenem-resistant-pseudomonas-aeruginosa-in-children-united-states-1999-2012
#11
Latania K Logan, Sumanth Gandra, Siddhartha Mandal, Eili Y Klein, Jordan Levinson, Robert A Weinstein, Ramanan Laxminarayan
BACKGROUND: Pseudomonas aeruginosa is a common cause of healthcare-associated infection. Multidrug-resistant (MDR) (>3 classes) and carbapenem-resistant (CR) P aeruginosa are significant threats globally. We used a large reference-laboratory database to study the epidemiology of P aeruginosa in children in the United States. METHODS: Antimicrobial susceptibility data from the Surveillance Network were used to phenotypically identify MDR and CR P aeruginosa isolates in children aged 1 to 17 years between January 1999 and July 2012...
November 16, 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/27794078/clemens-von-pirquet-a-remarkable-life-and-career
#12
REVIEW
Stanford T Shulman
From 1908 to 1929, Clemens von Pirquet was one of the world's most acclaimed pediatricians. Von Pirquet (1874-1929) trained at Vienna's Universitäts Kinderklinic under Theodor Escherich, the first Pediatric Infectious Diseases physician [ 1], and became the first Professor and Chair of Pediatrics at Johns Hopkins in 1909. He then succeeded his mentor Escherich as Professor and Chair of Pediatrics in Vienna, the most prestigious European pediatric position, when Escherich died unexpectedly in 1911. He held that position in Vienna until his shocking double suicide at age 54 with his wife in 1929...
October 28, 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/27856771/a-9-year-old-boy-with-a-chest-mass-and-eosinophilia
#13
Laura E Norton, Sean N Curtis, Jennifer L Goldman
No abstract text is available yet for this article.
December 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/27856770/update-from-the-advisory-committee-on-immunization-practices
#14
Jennifer E Schuster, Sean O'Leary, David W Kimberlin
The Advisory Committee on Immunization Practices (ACIP) consists of medical and public health experts who develop recommendations on vaccine use in the United States. The ACIP meets 3 times per year, and members and Centers for Disease Control (CDC) staff present findings and discuss vaccine research, vaccine effectiveness (VE) and safety, clinical trial results, and labeling/package insert information. Outbreaks of vaccine-preventable diseases and vaccine shortages are also discussed. Nonvoting representatives from the American Academy of Pediatrics and the Pediatric Infectious Diseases Society are present...
December 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/27856674/longitudinal-evaluation-of-language-impairment-in-youth-with-perinatally-acquired-human-immunodeficiency-virus-hiv-and-youth-with-perinatal-hiv-exposure
#15
Sean M Redmond, Tzy-Jyun Yao, Jonathan S Russell, Mabel L Rice, Howard J Hoffman, George K Siberry, Toni Frederick, Murli Purswani, Paige L Williams
BACKGROUND: Language impairment (LI) risk is increased for perinatally acquired human immunodeficiency virus-infected (PHIV) and perinatally exposed to HIV but uninfected (PHEU) youth. This study evaluates the persistence of LI in these groups. METHODS: The Clinical Evaluation of Language Fundamentals was repeated on participants of the Pediatric HIV/AIDS Cohort Study Adolescent Master Protocol 18 months postbaseline. Regression models identified factors associated with change in standardized score (SC) and the resolution or development of LI...
December 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/27856673/associations-of-memory-and-executive-functioning-with-academic-and-adaptive-functioning-among-youth-with-perinatal-hiv-exposure-and-or-infection
#16
Patricia A Sirois, Miriam C Chernoff, Kathleen M Malee, Patricia A Garvie, Lynnette L Harris, Paige L Williams, Steven P Woods, Molly L Nozyce, Betsy L Kammerer, Cenk Yildirim, Sharon L Nichols
BACKGROUND: Perinatally acquired HIV (PHIV) confers risk for neurocognitive impairment, which potentially affects school performance and functional independence of infected children. In this study, we examined the associations of 2 key neurocognitive domains, memory and executive function (EF), with academic and adaptive skills among youth with PHIV and perinatally HIV-exposed but uninfected (PHEU) youth. METHODS: Participants ages 9 to <19 years enrolled in the Pediatric HIV/AIDS Cohort Study's Memory and Executive Functioning Study completed standardized measures of reading and math...
December 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/27856672/executive-functioning-in-children-and-adolescents-with-perinatal-hiv-infection-and-perinatal-hiv-exposure
#17
Sharon L Nichols, Miriam C Chernoff, Kathleen M Malee, Patricia A Sirois, Steven P Woods, Paige L Williams, Cenk Yildirim, Dean Delis, Betsy Kammerer
BACKGROUND: Executive functions (EFs) are critical for management of life activities, but few studies have evaluated EFs in children and adolescents with perinatally acquired HIV (PHIV), who are at risk for problems in academics, behavior, and medication adherence. We compared EFs in youth with PHIV and in perinatally HIV-exposed but uninfected (PHEU) youth. METHODS: Four Delis-Kaplan Executive Function System (D-KEFS) subtests were administered to 173 youth with PHIV and 85 PHEU youth, aged 9 to <19 years, who were enrolled in the Pediatric HIV/AIDS Cohort Study (PHACS) Memory and Executive Functioning Study...
December 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/27856671/deformed-subcortical-structures-are-related-to-past-hiv-disease-severity-in-youth-with-perinatally-acquired-hiv-infection
#18
C Paula Lewis-de Los Angeles, Kathryn I Alpert, Paige L Williams, Kathleen Malee, Yanling Huo, John G Csernansky, Ram Yogev, Russell B Van Dyke, Elizabeth R Sowell, Lei Wang
BACKGROUND: Combination antiretroviral therapy has led to increased survival among youth with perinatally acquired HIV (PHIV). However, cognitive deficits continue to be common. Histopathological studies in adults have found HIV concentrated in subcortical structures, which are involved in sensory processing, movement, and higher-order cognition that emerges with development. METHODS: We conducted magnetic resonance imaging and cognitive testing in 40 youth with PHIV at one site of the Adolescent Master Protocol of the Pediatric HIV/AIDS Cohort Study...
December 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/27856670/brain-and-cognitive-development-among-u-s-youth-with-perinatally-acquired-human-immunodeficiency-virus-infection
#19
Kathleen M Malee, Renee A Smith, Claude A Mellins
No abstract text is available yet for this article.
December 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/27609072/best-practices-for-treatment-of-invasive-methicillin-susceptible-staphylococcus-aureus-infections-the-case-for-oxacillin
#20
James B Wood, Isaac P Thomsen, C Buddy Creech, Jason G Newland
No abstract text is available yet for this article.
December 2016: Journal of the Pediatric Infectious Diseases Society
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