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Not so neutral lipids: Metabolic regulation of the pre-metastatic niche.
Cell Metabolism 2022 December 7
How primary tumors alter distant tissue sites to facilitate seeding and metastasis remains unclear. In this issue, Gong et al. demonstrate that IL-1β-dependent lipid accumulation in lung mesenchymal cells supports both tumor growth and NK cell dysfunction, facilitating lung metastasis of primary breast tumors.
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