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Did circular DNA shape the evolution of mammalian genomes?
Trends in Biochemical Sciences 2022 October 22
Extrachromosomal circular DNA (eccDNA) can shape the genomes of somatic cells, but how it impacts genomes across generations is largely unexplored. We propose that genomes can rearrange via circular intermediates across generations and show that up to 6% of a mammalian genome can have changed gene order through eccDNA.
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