journal
MENU ▼
Read by QxMD icon Read
search

Trends in Biochemical Sciences

journal
https://www.readbyqxmd.com/read/28917971/how-fast-is-protein-ligand-association
#1
Stefano Gianni, Per Jemth
There is increasing interest in studying protein interactions and their role in cell biology using kinetics. However, there is confusion about the proper terminology in terms of the distinction between rates and rate constants. We recommend a more stringent use of the words speed, fast, slow, rate, and rate constant.
September 13, 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/28917970/how-do-enzymes-meet-nanoparticles-and-nanomaterials
#2
REVIEW
Ming Chen, Guangming Zeng, Piao Xu, Cui Lai, Lin Tang
Enzymes are fundamental biological catalysts responsible for biological regulation and metabolism. The opportunity for enzymes to 'meet' nanoparticles and nanomaterials is rapidly increasing due to growing demands for applications in nanomaterial design, environmental monitoring, biochemical engineering, and biomedicine. Therefore, understanding the nature of nanomaterial-enzyme interactions is becoming important. Since 2014, enzymes have been used to modify, degrade, or make nanoparticles/nanomaterials, while numerous nanoparticles/nanomaterials have been used as materials for enzymatic immobilization and biosensors and as enzyme mimicry...
September 13, 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/28916413/emerging-structural-understanding-of-amyloid-fibrils-by-solid-state-nmr
#3
REVIEW
Beat H Meier, Roland Riek, Anja Böckmann
Amyloid structures at atomic resolution have remained elusive mainly because of their extensive polymorphism and because their polymeric properties have hampered structural studies by classical approaches. Progress in sample preparation, as well as solid-state NMR methods, recently enabled the determination of high-resolution 3D structures of fibrils such as the amyloid-β fibril, which is involved in Alzheimer's disease. Notably, the simultaneous but independent structure determination of Aβ1-42, a peptide that forms fibrillar deposits in the brain of Alzheimer patients, by two independent laboratories, which yielded virtually identical results, has highlighted how structures can be obtained that allow further functional investigation...
September 12, 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/28893460/stress-activated-chaperones-a-first-line-of-defense
#4
REVIEW
Wilhelm Voth, Ursula Jakob
Proteins are constantly challenged by environmental stress conditions that threaten their structure and function. Especially problematic are oxidative, acid, and severe heat stress which induce very rapid and widespread protein unfolding and generate conditions that make canonical chaperones and/or transcriptional responses inadequate to protect the proteome. We review here recent advances in identifying and characterizing stress-activated chaperones which are inactive under non-stress conditions but become potent chaperones under specific protein-unfolding stress conditions...
September 8, 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/28870425/emerging-insights-into-the-roles-of-the-paf1-complex-in-gene-regulation
#5
REVIEW
S Branden Van Oss, Christine E Cucinotta, Karen M Arndt
The conserved, multifunctional Polymerase-Associated Factor 1 complex (Paf1C) regulates all stages of the RNA polymerase (Pol) II transcription cycle. In this review, we examine a diverse set of recent studies from various organisms that build on foundational studies in budding yeast. These studies identify new roles for Paf1C in the control of gene expression and the regulation of chromatin structure. In exploring these advances, we find that various functions of Paf1C, such as the regulation of promoter-proximal pausing and development in higher eukaryotes, are complex and context dependent...
September 1, 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/28864230/there-is-an-inclusion-for-that-material-properties-of-protein-granules-provide-a-platform-for-building-diverse-cellular-functions
#6
REVIEW
Daniel Kaganovich
Proteins perform a staggering variety of functions in the cell. Traditionally, protein function was thought to be hard-wired into the folded structure and conformational dynamics of each protein molecule. Recent work describes a new mode of protein functionality driven by the collective behavior of many different proteins; most of which lack a defined structure. These proteins form clusters or granules in which unstructured polypeptides interact transiently. Nonspecific multivalent interactions drive the formation of phase-separated structures resembling aggregates...
August 29, 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/28869131/in-the-hunger-games-the-winner-takes-everything
#7
Franziska Püschel, Cristina Muñoz-Pinedo
Entosis is an atypical form of cell death that occurs when a cell engulfs and kills another cell. A recent article by Overholtzer and colleagues indicates that glucose deprivation promotes entosis. AMP-activated protein kinase (AMPK) activation in the loser cells triggers their engulfment and elimination by winner cells, which endure starvation.
August 28, 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/28802547/good-ol-fat-links-between-lipid-signaling-and-longevity
#8
REVIEW
Victor Bustos, Linda Partridge
Aging is the single greatest risk factor for the development of disease. Understanding the biological molecules and mechanisms that modulate aging is therefore critical for the development of health-maximizing interventions for older people. The effect of fats on longevity has traditionally been disregarded as purely detrimental. However, new studies are starting to uncover the possible beneficial effects of lipids working as signaling molecules on health and longevity. These studies highlight the complex links between aging and lipid signaling...
August 9, 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/28801047/the-ribosome-holds-the-rna-polymerase-on-track-in-bacteria
#9
Bruno P Klaholz
The central dogma of molecular biology comprises two fundamental mechanistic steps of gene expression (transcription and translation), which, in bacteria, are coupled. A recent study provides structural insights into a supercomplex between the RNA polymerase and the ribosome, thus highlighting the synergy between two key macromolecular machineries in the cell.
August 8, 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/28784328/how-hsp90-and-cdc37-lubricate-kinase-molecular-switches
#10
REVIEW
Kliment A Verba, David A Agard
The Hsp90/Cdc37 chaperone system interacts with and supports 60% of the human kinome. Not only are Hsp90 and Cdc37 generally required for initial folding, but many kinases rely on the Hsp90/Cdc37 throughout their lifetimes. A large fraction of these 'client' kinases are key oncoproteins, and their interactions with the Hsp90/Cdc37 machinery are crucial for both their normal and malignant activity. Recently, advances in single-particle cryo-electron microscopy (cryoEM) and biochemical strategies have provided the first key molecular insights into kinase-chaperone interactions...
August 4, 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/28780273/shahaf-peleg-delaying-the-appointment-in-samarra
#11
(no author information available yet)
No abstract text is available yet for this article.
August 2, 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/28764927/d-tyrosyl-trna-deacylase-a-new-function
#12
Richard Calendar
d-Aminoacyl-tRNA deacylase (DTD) hydrolyzes d-amino acids mistakenly attached to tRNAs and, thus, has been implicated in perpetuating protein homochirality. Fifty years after the discovery of DTD, it has now been shown that its function extends beyond 'chiral proofreading' because it also eliminates glycine that has been erroneously coupled to tRNA(Ala).
July 29, 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/28716332/shaping-and-reshaping-transcriptome-plasticity-during-evolution
#13
Shobbir Hussain
Transcriptome plasticity, usually associated with alternative isoform generation, is recognised as a key mechanism driving proteomic diversity and biological complexity. Recent findings of Liscovitch-Brauer et al. and Ma et al. suggest that RNA base modifications are an additional central mode of transcriptome malleability that have the potential to determine evolutionary outcomes.
July 14, 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/28684008/ribosomal-chamber-music-toward-an-understanding-of-ires-mechanisms
#14
REVIEW
Hiroshi Yamamoto, Anett Unbehaun, Christian M T Spahn
Internal initiation is a 5'-end-independent mode of translation initiation engaged by many virus- and putatively some cell-encoded templates. Internal initiation is facilitated by specific RNA tertiary folds, called internal ribosomal entry sites (IRESs), in the 5' untranslated region (UTR) of the respective transcripts. In this review we discuss recent structural insight into how established IRESs first capture and then manipulate the eukaryotic translation machinery through non-canonical interactions and by guiding the intrinsic conformational flexibility of the eukaryotic ribosome...
July 3, 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/28669456/biphasic-modeling-of-mitochondrial-metabolism-dysregulation-during-aging
#15
REVIEW
Darren J Baker, Shahaf Peleg
Organismal aging is classically viewed as a gradual decline of cellular functions and a systemic deterioration of tissues that leads to an increased mortality rate in older individuals. According to the prevailing theory, aging is accompanied by a continuous and progressive decline in mitochondrial metabolic activity in cells. However, the most robust approaches to extending healthy lifespan are frequently linked with reduced energy intake or with lowering of mitochondrial activity. While these observations appear contradictory, recent work and technological advances demonstrate that metabolic deregulation during aging is potentially biphasic...
June 29, 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/28668327/an-updated-translation
#16
EDITORIAL
Nicole Neuman
No abstract text is available yet for this article.
June 28, 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/28739276/a-process-of-resection-dependent-nonhomologous-end-joining-involving-the-goddess-artemis
#17
REVIEW
Markus Löbrich, Penny Jeggo
DNA double-strand breaks (DSBs) are a hazardous form of damage that can potentially cause cell death or genomic rearrangements. In mammalian G1- and G2-phase cells, DSBs are repaired with two-component kinetics. In both phases, a fast process uses canonical nonhomologous end joining (c-NHEJ) to repair the majority of DSBs. In G2, slow repair occurs by homologous recombination. The slow repair process in G1 also involves c-NHEJ proteins but additionally requires the nuclease Artemis and DNA end resection. Here, we consider the nature of slow DSB repair in G1 and evaluate factors determining whether DSBs are repaired with fast or slow kinetics...
September 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/28734578/phosphatidylserine-is-the-signal-for-tam-receptors-and-their-ligands
#18
REVIEW
Greg Lemke
Nature repeatedly repurposes, in that molecules that serve as metabolites, energy depots, or polymer subunits are at the same time used to deliver signals within and between cells. The preeminent example of this repurposing is ATP, which functions as a building block for nucleic acids, an energy source for enzymatic reactions, a phosphate donor to regulate intracellular signaling, and a neurotransmitter to control the activity of neurons. A series of recent studies now consolidates the view that phosphatidylserine (PtdSer), a common phospholipid constituent of membrane bilayers, is similarly repurposed for use as a signal between cells and that the ligands and receptors of the Tyro3/Axl/Mer (TAM) family of receptor tyrosine kinases (RTKs) are prominent transducers of this signal...
September 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/28733116/a-bright-future-for-serial-femtosecond-crystallography-with-xfels
#19
REVIEW
Linda C Johansson, Benjamin Stauch, Andrii Ishchenko, Vadim Cherezov
X-ray free electron lasers (XFELs) have the potential to revolutionize macromolecular structural biology due to the unique combination of spatial coherence, extreme peak brilliance, and short duration of X-ray pulses. A recently emerged serial femtosecond (fs) crystallography (SFX) approach using XFEL radiation overcomes some of the biggest hurdles of traditional crystallography related to radiation damage through the diffraction-before-destruction principle. Intense fs XFEL pulses enable high-resolution room-temperature structure determination of difficult-to-crystallize biological macromolecules, while simultaneously opening a new era of time-resolved structural studies...
September 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/28579074/cytosolic-proteostasis-networks-of-the-mitochondrial-stress-response
#20
REVIEW
Davide D'Amico, Vincenzo Sorrentino, Johan Auwerx
Mitochondrial stress requires timely intervention to prevent mitochondrial and cellular dysfunction. Re-establishing the correct protein homeostasis is crucial for coping with mitochondrial stress and maintaining cellular homeostasis. The best-characterized adaptive pathways for mitochondrial stress involve a signal originating from stressed mitochondria that triggers a nuclear response. However, recent findings have shown that mitochondrial stress also affects a complex network of protein homeostasis pathways in the cytosol...
September 2017: Trends in Biochemical Sciences
journal
journal
26849
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"