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Clinical Characteristics of Children with Cerebral Injury preceding Treatment of Diabetic Ketoacidosis.

Nicole S Glaser, Kimberly S Quayle, Julie K McManemy, Lise E Nigrovic, Leah Tzimenatos, Michael J Stoner, Jonathan E Bennett, Jennifer L Trainor, Arleta Rewers, Jeff E Schunk, Sage R Myers, Maria Y Kwok, Kathleen M Brown, Simona Ghetti, T Charles Casper, Cody S Olsen, Nathan Kuppermann
Journal of Pediatrics 2022 November
Previous studies have identified more severe acidosis and higher blood urea nitrogen (BUN) as risk factors for cerebral injury during treatment of diabetic ketoacidosis (DKA) in children; however, cerebral injury also can occur before DKA treatment. We found that lower pH and higher BUN levels also were associated with cerebral injury at presentation.

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