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Journal of Pediatrics

Ather Ali, Theresa R Weiss, Anne Dutton, Douglas McKee, Kim D Jones, Susmita Kashikar-Zuck, Wendy K Silverman, Eugene D Shapiro
OBJECTIVE: To assess the feasibility of a mindfulness-based stress reduction (MBSR) program for adolescents with widespread chronic pain and other functional somatic symptoms and to make preliminary assessments of its clinical utility. STUDY DESIGN: Three cohorts of subjects completed an 8-week MBSR program. Child- and parent-completed measures were collected at baseline and 8 and 12 weeks later. Measures included the Functional Disability Inventory (FDI), the Fibromyalgia/Symptom Impact Questionnaire-Revised (FIQR/SIQR), the Pediatric Quality of Life Inventory, the Multidimensional Anxiety Scale (MASC2), and the Perceived Stress Scale...
January 12, 2017: Journal of Pediatrics
Jenny Lin, Aliva De, Lisa Figueiredo, Rochelle Maxwell, Emily Wasserman, Kelly Adams, Jacqueline Weingarten, Giles Peek, Michael Miksa
Pulmonary alveolar proteinosis (PAP) is a rare diffuse lung disease in the pediatric population. There are currently few cases documenting hemophagocytic lymphohistiocytosis as a cause for secondary PAP. We describe an ex-preterm child with secondary hemophagocytic lymphohistiocytosis, complicated by PAP and hypoxemic respiratory failure.
January 12, 2017: Journal of Pediatrics
Amy G Feldman, Ronald J Sokol, Regina M Hardison, Estella M Alonso, Robert H Squires, Michael R Narkewicz
OBJECTIVES: To assess the accuracy of blood lactate and lactate: pyruvate molar ratio (L:P) as a screen for mitochondrial, respiratory chain, or fatty acid oxidation disorders in children with pediatric acute liver failure (PALF); to determine whether serum lactate ≥ 2.5 mmol/L or L:P  ≥ 25 correlated with biochemical variables of clinical severity; and to determine whether lactate or L:P is associated with clinical outcome at 21 days. STUDY DESIGN: Retrospective review of demographic, clinical, laboratory, and outcome data for PALF study group participants who had lactate and pyruvate levels collected on the same day...
January 12, 2017: Journal of Pediatrics
John G Zampella, Shawn G Kwatra, Jaime Blanck, Bernard Cohen
No abstract text is available yet for this article.
January 12, 2017: Journal of Pediatrics
Chun-Hua Liao, Chi-Nien Chen
No abstract text is available yet for this article.
January 12, 2017: Journal of Pediatrics
Robin K Whyte, Harvey Nelson, Robin S Roberts, Barbara Schmidt
It has been reported in the 3 Benefits of Oxygen Saturation Targeting (BOOST-II) trials that changes in oximeter calibration software resulted in clearer separation between the oxygen saturations in the two trial target groups. A revised analysis of the published BOOST-II data does not support this conclusion.
January 12, 2017: Journal of Pediatrics
Amy G Feldman, Shikha S Sundaram, Brenda L Beaty, Allison Kempe
OBJECTIVES: To examine in liver transplant recipients at centers participating in the Pediatric Health Information System dataset the number of hospitalizations for respiratory syncytial virus (RSV) and vaccine-preventable infections (VPIs) in the first 2 years after transplantation, morbidity and mortality associated with these hospitalizations, and costs associated with these hospitalizations. STUDY DESIGN: A retrospective cohort study of patients <18 years of age who underwent liver transplantation at a Pediatric Health Information System center between January 1, 2004, and December 31, 2012...
January 11, 2017: Journal of Pediatrics
Steve G Robison, Juventila Liko
OBJECTIVE: To assess whether, during a 2012 pertussis outbreak, unvaccinated and poorly vaccinated cases occurred earlier on a community level. STUDY DESIGN: Pediatric pertussis among children 2 months to 10 years of age in the Oregon Sentinel Surveillance region during an epidemic starting at the beginning of 2012 were stratified by immunization status, age, zip code, and calendar date of disease onset. Differences in median onset as days between fully or mostly vaccinated, poorly vaccinated, and unvaccinated cases were examined overall and within local zip code areas...
January 11, 2017: Journal of Pediatrics
Tine Marie Pedersen, Jakob Stokholm, Jonathan Thorsen, Anna-Rosa Cecilie Mora-Jensen, Hans Bisgaard
OBJECTIVES: To study the association between antibiotic intake in pregnancy and the development of otitis media and placement of ventilation tubes (VTs) in the offspring under the hypothesis that antibiotics in pregnancy may alter the offspring's propensity for disease. STUDY DESIGN: Data from the 700 children in the Copenhagen Prospective Studies on Asthma in Childhood 2010 unselected birth cohort study were used. Information on maternal antibiotic use and other exposures during pregnancy was collected prospectively from interviews and validated in national registries...
January 11, 2017: Journal of Pediatrics
Márcio V F Donadio, João P Heinzmann-Filho, Fernanda M Vendrusculo, Patrícia X H Frasson, Paulo J C Marostica
OBJECTIVE: To evaluate the association of 6-minute walk test (6MWT) and other variables (anthropometry, chronic Pseudomonas aeroginosa colonization, pulmonary function, and respiratory muscle strength) with the risk of hospitalization for pulmonary exacerbation in children and adolescents with cystic fibrosis (CF). STUDY DESIGN: Cohort study that included patients with CF aged 6-18 years. All participants underwent spirometry, manovacuometry, and 6MWT during the 5-year follow-up...
January 10, 2017: Journal of Pediatrics
Monika K Goyal, Joel A Fein, Gia M Badolato, Judy A Shea, Maria E Trent, Stephen J Teach, Theoklis E Zaoutis, James M Chamberlain
OBJECTIVES: To assess whether clinical decision support, using computerized sexually transmitted infection (STI) risk assessments, results in increased STI testing of adolescents at high risk for STI. STUDY DESIGN: In a 2-arm, randomized, controlled trial conducted at a single, urban, pediatric emergency department, adolescents completed a computerized sexual health survey. For patients assigned to the intervention arm, attending physicians received decision support to guide STI testing based on the sexual health survey-derived STI risk; in the usual care arm, decision support was not provided...
January 10, 2017: Journal of Pediatrics
Dorothea Dumuid, Timothy Olds, Lucy K Lewis, Josep Antoni Martin-Fernández, Peter T Katzmarzyk, Tiago Barreira, Stephanie T Broyles, Jean-Philippe Chaput, Mikael Fogelholm, Gang Hu, Rebecca Kuriyan, Anura Kurpad, Estelle V Lambert, José Maia, Victor Matsudo, Vincent O Onywera, Olga L Sarmiento, Martyn Standage, Mark S Tremblay, Catrine Tudor-Locke, Pei Zhao, Fiona Gillison, Carol Maher
OBJECTIVE: To evaluate the relationship between children's lifestyles and health-related quality of life and to explore whether this relationship varies among children from different world regions. STUDY DESIGN: This study used cross-sectional data from the International Study of Childhood Obesity, Lifestyle and the Environment. Children (9-11 years) were recruited from sites in 12 nations (n = 5759). Clustering input variables were 24-hour accelerometry and self-reported diet and screen time...
January 10, 2017: Journal of Pediatrics
Tom E J Theunissen, Suzanne C E H Sallevelt, Debby M E I Hellebrekers, Bart de Koning, Alexandra T M Hendrickx, Bianca J C van den Bosch, Rick Kamps, Kees Schoonderwoerd, Radek Szklarczyk, Elvira N M Mulder-Den Hartog, Irenaeus F M de Coo, Hubert J M Smeets
Whole-exome sequencing identified multiple genetic causes in 2 infants with heterogeneous disease. Three gene defects in the first patient explained all symptoms, but manifestations were overlapping (blended phenotype). Two gene defects in the second patient explained nonoverlapping symptoms (composite phenotype). Whole-exome sequencing rapidly and comprehensively resolves heterogeneous genetic disease.
January 9, 2017: Journal of Pediatrics
Cheryl L Brosig, Laurel Bear, Sydney Allen, Raymond G Hoffmann, Amy Pan, Michele Frommelt, Kathleen A Mussatto
OBJECTIVE: To describe preschool neurodevelopmental outcomes of children with complex congenital heart disease (CHD), who were evaluated as part of a longitudinal cardiac neurodevelopmental follow-up program, as recommended by the American Heart Association and the American Academy of Pediatrics, and identify predictors of neurodevelopmental outcomes in these children. STUDY DESIGN: Children with CHD meeting the American Heart Association/American Academy of Pediatrics high-risk criteria for neurodevelopmental delay were evaluated at 4-5 years of age...
January 9, 2017: Journal of Pediatrics
Elsa Lorthe, Pierre-Yves Ancel, Héloïse Torchin, Monique Kaminski, Bruno Langer, Damien Subtil, Loïc Sentilhes, Catherine Arnaud, Bruno Carbonne, Thierry Debillon, Pierre Delorme, Claude D'Ercole, Michel Dreyfus, Cécile Lebeaux, Jacques-Emmanuel Galimard, Christophe Vayssiere, Norbert Winer, Laurence Foix L'Helias, François Goffinet, Gilles Kayem
OBJECTIVE: To assess the impact of latency duration on survival, survival without severe morbidity, and early-onset sepsis in infants born after preterm premature rupture of membranes (PPROM) at 24-32 weeks' gestation. STUDY DESIGN: This study was based on the prospective national population-based Etude Épidémiologique sur les Petits Ȃges Gestationnels 2 cohort of preterm births and included 702 singletons delivered in France after PPROM at 24-32 weeks' gestation...
January 9, 2017: Journal of Pediatrics
Daniël R Hoekman, Judith Zeevenhooven, Faridi S van Etten-Jamaludin, Iuke Douwes Dekker, Marc A Benninga, Merit M Tabbers, Arine M Vlieger
OBJECTIVE: To investigate the magnitude and determinants of the placebo response in studies with pediatric abdominal pain-related functional gastrointestinal disorders. STUDY DESIGN: The Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, and CINAHL were searched for systematic reviews and randomized placebo-controlled trials concerning children 4-18 years of age with an abdominal pain-related functional gastrointestinal disorder. The primary outcome was the pooled proportion of subjects assigned to placebo with improvement as defined by the authors...
January 9, 2017: Journal of Pediatrics
Janet L Engstrom, Aloka L Patel, Paula P Meier
No abstract text is available yet for this article.
January 9, 2017: Journal of Pediatrics
Jonathan Y Bernard, Martine Armand, Hugo Peyre, Cyrielle Garcia, Anne Forhan, Maria De Agostini, Marie-Aline Charles, Barbara Heude
OBJECTIVE: To examine the relationship of polyunsaturated fatty acid (PUFA) in breast milk with children's IQ. STUDY DESIGN: In the French Etude des Déterminants pré- et postnatals précoces du développement et de la santé de l'Enfant (EDEN) mother-child cohort, colostrum samples were collected at the maternity unit. Colostrum omega-6 and omega-3 PUFA were analyzed by gas chromatography. At age 5-6 years, the IQs of 1080 children were assessed using the Wechsler Preschool and Primary Scale of Intelligence-III...
January 9, 2017: Journal of Pediatrics
Marco T Luque, Cathy A Jenkins, Bryan E Shepherd, Denis Padgett, Vanessa Rouzier, Regina Célia M Succi, Daisy M Machado, Catherine C McGowan, Sten H Vermund, Jorge A Pinto
OBJECTIVES: To assess the risks of and factors associated with mortality, loss to follow-up, and changing regimens after children with HIV infected perinatally initiate combination antiretroviral therapy (cART) in Latin America and the Caribbean. STUDY DESIGN: This 1997-2013 retrospective cohort study included 1174 antiretroviral therapy-naïve, perinatally infected children who started cART age when they were younger than 18 years of age (median 4.7 years; IQR 1...
January 9, 2017: Journal of Pediatrics
Judy H Squires, Amber Bill, Jessica Thieret, James E Squires
No abstract text is available yet for this article.
January 4, 2017: Journal of Pediatrics
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