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Journal of Pediatrics

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https://www.readbyqxmd.com/read/28215425/outcomes-of-lung-transplantation-for-infants-and-children-with-genetic-disorders-of-surfactant-metabolism
#1
Whitney B Eldridge, Qunyuan Zhang, Albert Faro, Stuart C Sweet, Pirooz Eghtesady, Aaron Hamvas, F Sessions Cole, Jennifer A Wambach
OBJECTIVE: To compare outcomes of infants and children who underwent lung transplantation for genetic disorders of surfactant metabolism (SFTPB, SFTPC, ABCA3, and NKX2-1) over 2 epochs (1993-2003 and 2004-2015) at St Louis Children's Hospital. STUDY DESIGN: We retrospectively reviewed clinical characteristics, mortality, and short- and long-term morbidities of infants (transplanted at <1 year; n = 28) and children (transplanted >1 year; n = 16) and compared outcomes by age at transplantation (infants vs children) and by epoch of transplantation...
February 16, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28209292/cholesterol-screening-and-treatment-practices-and-preferences-a-survey-of-united-states-pediatricians
#2
Sarah D de Ferranti, Angie Mae Rodday, Susan K Parsons, William L Cull, Karen G O'Connor, Stephen R Daniels, Laurel K Leslie
OBJECTIVES: To determine pediatricians' practices, attitudes, and barriers regarding screening for and treatment of pediatric dyslipidemias in 9- to 11-year-olds and 17- to 21-year-olds. STUDY DESIGN: American Academy of Pediatrics (AAP) 2013-2014 Periodic Survey of a national, randomly selected sample of 1627 practicing AAP physicians. Pediatricians' responses were described and modeled. RESULTS: Of 614 (38%) respondents who met eligibility criteria, less than half (46%) were moderately/very knowledgeable about the 2008 AAP cholesterol statement; fewer were well-informed about 2011 National Heart, Lung, and Blood Institute Guidelines or 2007 US Preventive Service Task Force review (both 26%)...
February 13, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28215936/alcohol-s-harm-to-children-findings-from-the-2015-united-states-national-alcohol-s-harm-to-others-survey
#3
Lauren M Kaplan, Madhabika B Nayak, Thomas K Greenfield, Katherine J Karriker-Jaffe
OBJECTIVES: To examine the prevalence and severity of alcohol's harm to children in the US and the relationship of the harmer to the child, and to examine caregivers' sociodemographic characteristics, alcohol use, and exposure to harm due to a drinking spouse/partner or other family member as risk factors for alcohol's harm to children. STUDY DESIGN: We report data on 764 caregivers (defined as persons with parental responsibility for at least 1 child aged ≤17 years) from the 2015 National Alcohol's Harm to Others Survey, a dual-frame national sample of US adults...
February 10, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28196683/spontaneous-umbilical-cord-hematoma
#4
Puneet Kumar Arora, Sindhu Mohandas, Sarah McAndrew, Vijender Karody
No abstract text is available yet for this article.
February 10, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28196682/mode-of-delivery-and-risk-of-celiac-disease-risk-of-celiac-disease-and-age-at-gluten-introduction-cohort-study
#5
Elena Lionetti, Stefania Castellaneta, Ruggiero Francavilla, Alfredo Pulvirenti, Carlo Catassi
OBJECTIVE: To determine whether the mode of delivery is associated with the risk of celiac disease (CD) in a cohort of children genetically predisposed to CD prospectively followed from birth. STUDY DESIGN: By telephone interview, we recorded information on the mode of delivery of children participating in the Risk of Celiac Disease and Age at Gluten Introduction study, a multicenter, prospective intervention trial that compared early and delayed introduction of gluten in infants with at least 1 first-degree relative affected with CD...
February 10, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28196681/safety-and-efficacy-of-ferric-carboxymaltose-in-children-and-adolescents-with-iron-deficiency-anemia
#6
LETTER
Elpis Mantadakis, Jelena Roganovic
No abstract text is available yet for this article.
February 10, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28196680/trajectories-of-substance-use-frequency-among-adolescents-seen-in-primary-care-implications-for-screening
#7
Scott E Hadland, Sarah H Copelas, Sion K Harris
OBJECTIVE: To identify trajectories of substance use in a prospective cohort of adolescent primary care patients one year after a clinic visit. STUDY DESIGN: We recruited 12- to 18-year-olds from 9 New England practices between 2005 and 2008 and identified 5 trajectories of substance use. We first distinguished adolescents with no past-year use at a baseline clinic visit and at 12-month follow-up (trajectory A). For adolescents who used substances, we assessed past 90-day use at both timepoints, and identified the remaining 4 trajectories based on frequency of use...
February 10, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28190518/brain-computed-tomography-compared-with-facial-3-dimensional-computed-tomography-for-diagnosis-of-facial-fractures
#8
Sun Hwa Lee, Seong Jong Yun, Seokyong Ryu, Seoung Won Choi, Hye Jin Kim, Tae Kyug Kang, Sung Chan Oh, Suk Jin Cho
OBJECTIVES: To compare the detection of facial fractures and radiation dose between brain computed tomography (CT) and facial 3-dimensional (3D) CT in pediatric patients who have experienced a trauma. STUDY DESIGN: Four hundred pediatric patients who experienced a trauma and underwent immediate brain CT and facial 3D CT between January 2016 and June 2016 were included in this retrospective study. Two reviewers independently analyzed and determined the presence of the facial fractures of 8 anatomic regions based on brain CT and facial 3D CT over a 1-week interval...
February 9, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28189300/macular-carotenoids-aerobic-fitness-and-central-adiposity-are-associated-differentially-with-hippocampal-dependent-relational-memory-in-preadolescent-children
#9
Kelsey M Hassevoort, Sarah E Khazoum, John A Walker, Sasha M Barnett, Lauren B Raine, Billy R Hammond, Lisa M Renzi-Hammond, Arthur F Kramer, Naiman A Khan, Charles H Hillman, Neal J Cohen
OBJECTIVES: To examine the associations of macular pigment carotenoids (lutein, meso-zeaxanthin, and zeaxanthin), aerobic fitness, and central adiposity with hippocampal-dependent relational memory in prepubescent children. STUDY DESIGN: Children between 7 and 10 years of age (n = 40) completed a task designed to assess relational memory performance and participated in aerobic fitness, adiposity, and macular pigment optical density (MPOD) assessment. Aerobic fitness was assessed via a modified Balke treadmill protocol designed to measure maximal oxygen volume...
February 8, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28187964/brain-perfusion-and-diffusion-abnormalities-in-children-treated-for-posterior-fossa-brain-tumors
#10
Matthew D Li, Nils D Forkert, Palak Kundu, Cheryl Ambler, Robert M Lober, Terry C Burns, Patrick D Barnes, Iris C Gibbs, Gerald A Grant, Paul G Fisher, Samuel H Cheshier, Cynthia J Campen, Michelle Monje, Kristen W Yeom
OBJECTIVE: To compare cerebral perfusion and diffusion in survivors of childhood posterior fossa brain tumor with neurologically normal controls and correlate differences with cognitive dysfunction. STUDY DESIGN: We analyzed retrospectively arterial spin-labeled cerebral blood flow (CBF) and apparent diffusion coefficient (ADC) in 21 patients with medulloblastoma (MB), 18 patients with pilocytic astrocytoma (PA), and 64 neurologically normal children. We generated ANCOVA models to evaluate treatment effects on the cerebral cortex, thalamus, caudate, putamen, globus pallidus, hippocampus, amygdala, nucleus accumbens, and cerebral white matter at time points an average of 5...
February 7, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28185627/epidemiology-of-bleeding-in-critically-ill-children
#11
Lauren J White, Ryan Fredericks, Candace N Mannarino, Stephen Janofsky, Edward Vincent S Faustino
OBJECTIVE: To determine the epidemiology of bleeding in critically ill children. STUDY DESIGN: We conducted a cohort study of children <18 years old admitted to the pediatric intensive care unit for >24 hours and without clinically relevant bleed (CRB) on admission. CRB was defined as resulting in severe physiologic derangements, occurring at a critical site or requiring major therapeutic interventions. Using a novel bleeding assessment tool that we developed, characteristics of the CRB were abstracted from the medical records independently and in duplicate...
February 6, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28185626/prevalence-of-concomitant-acute-bacterial-meningitis-in-neonates-with-febrile-urinary-tract-infection-a-retrospective-cross-sectional-study
#12
Sowdhamini S Wallace, Danielle N Brown, Andrea T Cruz
OBJECTIVE: To describe the frequency of concomitant acute bacterial meningitis (ABM) in neonates with febrile urinary tract infection (UTI). STUDY DESIGN: This was a retrospective cross-sectional study from 2005 to 2013 of infants ≤30 days old evaluated in the emergency department of a quaternary care children's hospital with fever and laboratory-confirmed UTI. Definite ABM was defined as cerebrospinal fluid (CSF) culture with growth of pathogenic bacteria and probable ABM if pleocytosis with ≥ 20 white blood cell was present in an antibiotic-pretreated patient...
February 6, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28185625/impact-of-erythropoiesis-stimulating-agents-on-behavioral-measures-in-children-born-preterm
#13
Jean R Lowe, Rebecca E Rieger, Natalia C Moss, Ronald A Yeo, Sarah Winter, Shrena Patel, John Phillips, Richard Campbell, Shawna Baker, Sean Gonzales, Robin K Ohls
OBJECTIVE: To evaluate the impact of erythropoiesis-stimulating agents (ESAs) administered during initial hospitalization and family demographic factors on behavior at 3.5-4 years of age. STUDY DESIGN: Children were enrolled who had previously participated in a randomized study of ESAs (n = 35) or placebo (n = 14) in infants born preterm with birth weights of 500-1250 g. A term healthy control group (n = 22) also was recruited. Behavior was evaluated by parent report with the Behavioral Assessment System of Children-2...
February 6, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28189301/auditory-exposure-in-the-neonatal-intensive-care-unit-room-type-and-other-predictors
#14
Roberta Pineda, Polly Durant, Amit Mathur, Terrie Inder, Michael Wallendorf, Bradley L Schlaggar
OBJECTIVE: To quantify early auditory exposures in the neonatal intensive care unit (NICU) and evaluate how these are related to medical and environmental factors. We hypothesized that there would be less auditory exposure in the NICU private room, compared with the open ward. STUDY DESIGN: Preterm infants born at ≤ 28 weeks gestation (33 in the open ward, 25 in private rooms) had auditory exposure quantified at birth, 30 and 34 weeks postmenstrual age (PMA), and term equivalent age using the Language Environmental Acquisition device...
February 2, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28162769/cord-blood-biomarkers-of-placental-maternal-vascular-underperfusion-predict-bronchopulmonary-dysplasia-associated-pulmonary-hypertension
#15
Karen K Mestan, Nina Gotteiner, Nicolas Porta, William Grobman, Emily J Su, Linda M Ernst
OBJECTIVE: To assess whether cord blood biomarkers associated with placental maternal vascular underperfusion (MVU) are predictive of bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH). STUDY DESIGN: Premature infants enrolled in a longitudinal cohort study were randomly sampled from 4 gestational age strata (n = 190, range 23-36 weeks). Fifteen factors from a human angiogenesis panel were measured in cord blood using multiplex immunoassay...
February 2, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28162768/response-to-name-in-infants-developing-autism-spectrum-disorder-a-prospective-study
#16
Meghan Miller, Ana-Maria Iosif, Monique Hill, Gregory S Young, A J Schwichtenberg, Sally Ozonoff
OBJECTIVE: To examine longitudinal patterns of response to name from 6-24 months of age in infants at high and low risk for autism spectrum disorder (ASD). STUDY DESIGN: A response to name task was tested at 6, 9, 12, 15, 18, and 24 months of age in 156 infant siblings of children with ASD (high-risk) or typical development (low-risk). At 36 months of age, participants were classified into 1 of 3 outcome groups: group with ASD (n = 20), high-risk group without ASD (n = 76), or low-risk group without ASD (n = 60)...
February 2, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28161203/questioning-the-utility-of-laryngoscopy-in-the-evaluation-of-pediatric-gastroesophageal-reflux
#17
EDITORIAL
Jonathan B Ida, Dana M Thompson
No abstract text is available yet for this article.
February 1, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28161202/analysis-of-children-and-adolescents-with-familial-hypercholesterolemia
#18
Ilenia Minicocci, Simone Pozzessere, Cristina Prisco, Anna Montali, Alessia di Costanzo, Eliana Martino, Francesco Martino, Marcello Arca
OBJECTIVE: To evaluate the effectiveness of criteria based on child-parent assessment in predicting familial hypercholesterolemia (FH)-causative mutations in unselected children with hypercholesterolemia. STUDY DESIGN: LDLR, APOB, and PCSK9 genes were sequenced in 78 children and adolescents (mean age 8.4 ± 3.7 years) with clinically diagnosed FH. The presence of polygenic hypercholesterolemia was further evaluated by genotyping 6 low-density lipoprotein cholesterol (LDL-C)-raising single-nucleotide polymorphisms...
February 1, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28161201/neonatal-hemochromatosis-blitz-diagnosis-results-in-favorable-outcome
#19
Christiane Sokollik, Bianca Kreiter, Rainer Wolf
No abstract text is available yet for this article.
February 1, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28161200/predictors-of-infant-body-composition-at-5-months-of-age-the-healthy-start-study
#20
Katherine A Sauder, Jill L Kaar, Anne P Starling, Brandy M Ringham, Deborah H Glueck, Dana Dabelea
OBJECTIVE: To examine associations of demographic, perinatal, and infant feeding characteristics with offspring body composition at approximately 5 months of age. STUDY DESIGN: We collected data on 640 mother/offspring pairs from early pregnancy through approximately 5 months of age. We assessed offspring body composition with air displacement plethysmography at birth and approximately 5 months of age. Linear regression analyses examined associations between predictors and fat-free mass, fat mass, and percent fat mass (adiposity) at approximately 5 months...
February 1, 2017: Journal of Pediatrics
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