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Retrospective Cohort Study of the Incidence and Outcomes of Jarisch-Herxheimer Reactions After Treatment of Infectious Syphilis in Late Pregnancy.

Stephen Macumber, Ameeta E Singh, Jennifer Gratrix, Joan L Robinson, Petra Smyczek, Lindsay Rathjen, Cameron Sklar
Sexually Transmitted Diseases 2022 October 2
ABSTRACT: Of 39 pregnant women at ≥20 weeks' gestation treated with benzathine penicillin G for infectious syphilis, we identified only 2 mild Jarisch-Herxheimer reactions. There were no immediate fetal sequelae. Data from our study do not support the recommendation for routine admission for the treatment of infectious syphilis in late pregnancy.

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