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Sexually Transmitted Diseases

Sarah Kidd, Virginia B Bowen, Elizabeth A Torrone, Gail Bolan
BACKGROUND: Recent increases in reported congenital syphilis have led to an urgent need to identify interventions that will have the greatest impact on congenital syphilis prevention. We sought to create a congenital syphilis prevention cascade using national syphilis surveillance data to (1) estimate the proportion of potential congenital syphilis cases averted with current prevention efforts, and (2) develop a classification framework to better describe why reported cases were not averted...
March 14, 2018: Sexually Transmitted Diseases
Ahmed M Kassem, Jared Bartschi, Kris K Carter
During 2011-2015 in Idaho, 14 (7%) of 193 persons with early syphilis had repeat syphilis. Persons with repeat infections were more likely to have had secondary or early latent syphilis (P = 0.037) and be infected with HIV (P < 0.001) compared with those having one infection.
March 14, 2018: Sexually Transmitted Diseases
Elizabeth A Torrone, William C Miller
No abstract text is available yet for this article.
March 13, 2018: Sexually Transmitted Diseases
James Matthias, Gayle Keller, Susan Cha, Craig Wilson, Thomas A Peterman
BACKGROUND: Before searching prior records, sexually transmitted disease (STD) programs use syphilis reactor grids to exclude some reactive non-treponemal test results (RNTs) based on patient age, sex, and test titer. We propose a new algorithm that starts with comparing RNTs to previous syphilis non-treponemal tests and current treponemal test results. METHODS: De-duplicated RNTs from Florida's surveillance system (2006-2015) were extracted and stratified on morbidity...
March 13, 2018: Sexually Transmitted Diseases
Christopher B Hurt
No abstract text is available yet for this article.
March 13, 2018: Sexually Transmitted Diseases
C L Shannon, C C Bristow, N A Hoff, A Wynn, M Nguyen, A Medina-Marino, J Cabeza, A W Rimoin, J D Klausner
BACKGROUND: Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Trichomonas vaginalis (TV) infections during pregnancy are linked with adverse birth outcomes. However, few countries have prenatal CT, NG, or TV screening programs. In this study, we aimed to evaluate the acceptability and feasibility of CT, NG, and TV screening and treatment among pregnant women across six low-to-middle income countries. METHODS: A total 1,817 pregnant women were screened for CT, NG, and TV in Botswana, the Democratic Republic of Congo (DRC), Haiti, South Africa, and Vietnam...
March 9, 2018: Sexually Transmitted Diseases
Susan Cha, James M Matthias, Mohammad Rahman, Julia A Schillinger, Bruce W Furness, River A Pugsley, Sarah Kidd, Kyle T Bernstein, Thomas A Peterman
BACKGROUND: Health departments prioritize investigations of reported reactive serologic tests based on age, sex, and titer using reactor grids. We wondered how reactor grids are used in different programs, and if administratively closing investigations of low-titer tests could lead to missed primary syphilis cases. METHODS: We obtained a convenience sample of reactor grids from 13 health departments. Interviews with staff from several jurisdictions described the role of grids in surveillance and intervention...
March 9, 2018: Sexually Transmitted Diseases
Sidharath D Thakur, Nidhi R Parmar, Jo-Anne R Dillon
No abstract text is available yet for this article.
March 9, 2018: Sexually Transmitted Diseases
Ellen N Kersh, Sheila A Lukehart
The first session at the 2016 Syphilis Summit provided an opportunity for laboratory researchers and clinicians to comment on gaps in biomedical knowledge and technologies. Predominant themes in the presentations and discussion included the need for optimization of existing diagnostic tests, commercial availability and FDA approval of nucleic acid amplification tests for primary and secondary syphilis, development of sensitive and specific new blood tests for diagnosis of active (vs. treated) syphilis infection, clarification of the best measures for adequacy of response to treatment, continued study of complications of syphilis including neuro- and ocular syphilis, and development of a safe and effective vaccine that will protect against transmission and complications of disseminated infection (including congenital and neurosyphilis)...
March 9, 2018: Sexually Transmitted Diseases
Caroline E Cameron
Syphilis, caused by the spirochete Treponema pallidum subspecies pallidum, continues to be a prevalent disease in low- and middle-income countries, and has re-emerged in key populations, including men who have sex with men, in high-income nations. The rising number of cases shows syphilis elimination will require augmentation of public health screening and treatment campaigns with syphilis vaccine development and implementation initiatives. Optimal vaccine candidates, deciphered from careful consideration of the pathogenic mechanisms employed by T...
March 9, 2018: Sexually Transmitted Diseases
Lao-Tzu Allan-Blitz, Elisa Mokany, Shelley Miller, Rachel Wee, Chelsea Shannon, Jeffrey D Klausner
BACKGROUND: Mycoplasma genitalium is an important cause of bacterial sexually transmitted diseases. Diagnosis and susceptibility testing of Mycoplasma genitalium are limited by the fastidious nature of the organism. Therefore, the prevalence of infection and azithromycin resistance are poorly studied. METHODS: We conducted an exploratory study on remnant clinical specimens. We collected remnant DNA from urine samples and clinical swabs (cervical/vaginal, rectal, and pharyngeal) previously tested for Neisseria gonorrhoeae and Chlamydia trachomatis using the Cobas 4800 CT/NG assay (Roche Molecular Systems, Pleasanton, CA) between March-April 2017 from across the University of California, Los Angeles Health System...
March 5, 2018: Sexually Transmitted Diseases
Jungwon Yoon, Heather R Elder, Rebecca Hawrusik, R Monina Klevens, Kathleen A Roosevelt, Katherine K Hsu
A mean of 4.5 days until treatment was documented in a subset of reported laboratory-confirmed Massachusetts chlamydia cases selected for active case report form (CRF) completion. Treatment delay was associated with longer test result turnaround time, and absence of symptoms or contact to STD. Non-metropolitan vs. metropolitan residence did not appear to impact treatment time.
March 2, 2018: Sexually Transmitted Diseases
Julia C Dombrowski, Matthew R Golden, Lindley A Barbee, Christine M Khosropour
Among 307 patients enrolled in an HIV pre-exposure prophylaxis (PrEP) program in the Public Health - Seattle & King County STD Clinic, 52 patients (17%) did not fill their PrEP prescription and 40% of those who started PrEP discontinued it at least once within 12 months.
February 26, 2018: Sexually Transmitted Diseases
Marjan Javanbakht, Drew Westmoreland, Pamina Gorbach
BACKGROUND: The objective of this study was to examine the proportion of missed infections and correlates of pharyngeal gonorrhea among young people attending public STD clinics. METHODS: We conducted a case control study of 245 young men and women between April 2012 and May 2014. Participants were eligible for inclusion if they were: (1) age 15 - 29 years, (2) reported giving oral sex to a partner of the opposite sex, in the past 90 days, and (3) attended one of twelve public STD clinics in Los Angeles County...
February 26, 2018: Sexually Transmitted Diseases
Aggie J Noah, Tse-Chuan Yang, Wei-Lin Wang
BACKGROUND: We investigate the roles of residential racial segregation and income inequality for the black-white disparity in acquiring sexually transmitted diseases (STD) during pregnancy in a multilevel framework. METHODS: The analytic sample consisted of non-Hispanic white (N = 79,271) or non-Hispanic black (N = 17,669) mothers from 2012 population birth data from Pennsylvania. We used the 2009-2013 American Community Survey for neighborhood characteristics of mothers; we used multilevel models...
February 26, 2018: Sexually Transmitted Diseases
Lauren F FitzHarris, Christopher H Johnson, Steven R Nesheim, Nadia L Oussayef, Allan W Taylor, Ayanna Harrison, Nan Ruffo, Kim Burley, Lawrence House, Emilia H Koumans
OBJECTIVE: To analyze prenatal human immunodeficiency virus (HIV) testing rates over time and describe the impact of state HIV testing laws on prenatal testing. METHODS: During 2004-2011, self-reported prenatal HIV testing data for women with live births in 35 states and New York City were collected. Prevalence of testing was estimated overall and by state and year. An annual percent change was calculated in states with at least six years of data to analyze testing changes over time...
February 26, 2018: Sexually Transmitted Diseases
Katherine K Hsu
No abstract text is available yet for this article.
February 26, 2018: Sexually Transmitted Diseases
Thomas Bertrand, Madeline C Montgomery, Philip A Chan
No abstract text is available yet for this article.
February 26, 2018: Sexually Transmitted Diseases
Patrick Sullivan
No abstract text is available yet for this article.
February 26, 2018: Sexually Transmitted Diseases
Achilleas Tsoumanis, Niel Hens, Chris Richard Kenyon
BACKGROUND: Neisseria gonorrhoeae (gonorrhea) could become untreatable in the near future. Indeed, while the treatment of symptomatic gonorrhea in core groups, such men who have sex with men (MSM), is crucial for gonorrhea control programs, screening for and treating asymptomatic gonorrhea/Chlamydia trachomatis(chlamydia) in MSM may contribute to antibiotic resistance in gonorrhea. In this systematic review we aim to assess if there is evidence that screening MSM for gonorrhea/chlamydia is associated with a decline in the prevalence of these infections...
February 26, 2018: Sexually Transmitted Diseases
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