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Control of S phase duration: a replication capacity model with E2F transcription at its heart.
Molecular & Cellular Oncology 2021 March 9
DNA replication capacity, the maximal amount of DNA a cell can synthesize at any given time during S phase, is controlled by E2F-dependent transcription. Controlling replication capacity limits the replication rate and provides a robust mechanism to keep replication fork speed within an optimal range whilst ensuring timely completion of genome duplication.
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