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Multi-Level Regulation of Opioid-Induced Respiratory Depression.

Barbara Palkovic, Vitaliy Marchenko, Edward J Zuperku, Eckehard A E Stuth, Astrid G Stucke
Physiology 2020 November 2
Opioids depress minute ventilation primarily by reducing respiratory rate. This results from direct effects on the preBötzinger Complex as well as from depression of the Parabrachial/Kölliker-Fuse Complex, which provides excitatory drive to preBötzinger Complex neurons mediating respiratory phase-switch. Opioids also depress awake drive from the forebrain and chemodrive.

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