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Two-photon photodynamic ablation of tumour cells using an RGD peptide-conjugated ruthenium(II) photosensitiser.
Chemical Communications : Chem Comm 2020 September 18
An RGD-peptide conjugated ruthenium(ii) complex has been developed, which functions as a two-photon absorption (TPA) photodynamic therapy (PDT) agent for ablating tumours by selectively targeting the mitochondria of integrin αvβ3-rich tumour cells. This approach offers a new and effective design and application for tumour-targeting metallo-anticancer drugs via two-photon PDT.
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