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Metabolic remodeling in E.coli MG1655. A prophage e14-encoded small RNA, co293, post transcriptionally regulates transcription factors HcaR and FadR.
FEBS Journal 2020 Februrary 16
In previous studies we have shown the existence of metabolic remodeling in glucose-grown E. coli MG1655 cells expressing the esterase Orf306 from the opd island of Sphingobium fuliginis. We now show that Orf306-dependent metabolic remodeling is due to regulation of a novel small RNA (sRNA). Endogenous propionate, produced due to the esterase/lipase activity of Orf306, repressed expression of a novel E. coli sRNA, co293. This sRNA post-transcriptionally regulates expression of the transcription factors HcaR and FadR either by inhibiting translation or by destabilizing their transcripts. Hence, repression of co293 expression elevates the levels of HcaR and FadR with consequent activation of alternative carbon catabolic pathways. HcaR activates the hca and mhp operons leading to up-regulation of the phenyl propionate (PP) and hydroxy phenyl propionate (HPP) degradation pathways. Similarly, FadR stimulates the expression of the transcription factor IclR which negatively regulates the glyoxylate bypass pathway genes, aceBAK.
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