journal
MENU ▼
Read by QxMD icon Read
search

FEBS Journal

journal
https://www.readbyqxmd.com/read/28444969/metabolic-reprogramming-and-epithelial-to-mesenchymal-transition-in-cancer
#1
REVIEW
Marco Sciacovelli, Christian Frezza
Several lines of evidence indicate that during transformation epithelial cancer cells can acquire mesenchymal features via a process called epithelial-to-mesenchymal transition (EMT). This process endows cancer cells with increased invasive and migratory capacity, enabling tumour dissemination and metastasis. EMT is associated with a complex metabolic reprogramming, orchestrated by EMT transcription factors, which support the energy requirements of increased motility and growth in harsh environmental conditions...
April 26, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28440944/the-regulatory-significance-of-tag-recycling-in-the-mycobacterial-pup-proteasome-system
#2
Yifat Elharar, Shai Schlussel, Nir Hecht, Michael M Meijler, Eyal Gur
Pup, a ubiquitin analog, tags proteins for degradation by the bacterial proteasome. As an intracellular proteolytic system, the Pup-proteasome system (PPS) must be carefully regulated to prevent excessive protein degradation. Currently, those factors underlying PPS regulation remain poorly understood. Here, experimental analysis combined with theoretical modeling of in vivo protein pupylation revealed how the basic PPS design allows stable and controlled protein pupylation. Specifically, the recycling of Pup when targets are degraded allows the PPS to maintain steady state levels of protein pupylation and degradation at a rate limited by proteasome function, and at a pupylome level limited by Pup concentrations...
April 25, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28440919/rev7-the-regulatory-subunit-of-pol%C3%AE-undergoes-uv-induced-and-cul4-dependent-degradation
#3
Audesh Bhat, Zhoushuai Qin, Guifen Wang, Wangyang Chen, Wei Xiao
In eukaryotic cells, Rev7 interacts with Rev3 and functions as a regulatory subunit of Polζ, a translesion DNA synthesis (TLS) polymerase. In addition to its role in TLS, mammalian Rev7, also known as Mad2B/Mad2L2, participates in multiple cellular activities including cell cycle progression and double-strand break repair through its interaction with several proteins. Here we show that in mammalian cells Rev7 undergoes ubiquitin/proteasome-mediated degradation upon UV irradiation in a time-dependent manner...
April 25, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28429420/the-crystal-structure-of-a-new-o-demethylase-from-sphingobium-sp-strain-syk-6
#4
Ayaka Harada, Naofumi Kamimura, Koh Takeuchi, Hong Yang Yu, Eiji Masai, Toshiya Senda
In the cell, tetrahydrofolate derivatives with a C1 unit are utilized in various ways, such as for the synthesis of amino acids and nucleic acids. While tetrahydrofolate derivatives with the C1 unit are typically produced in the glycine cleavage system, Sphingobium sp. strain SYK-6, which can utilize lignin-derived aromatic compounds as a sole source of carbon and energy, lacks this pathway, probably due to its unique nutrient requirements. In this bacterium, tetrahydrofolate-dependent O-demethylases in catabolic pathways for lignin-derived aromatic compounds seem to be involved in the C1 metabolism...
April 20, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28425175/haemorrhagic-snake-venom-metalloproteases-and-human-adams-cleave-lrp5-6-which-disrupts-cell-cell-adhesions-in-vitro-and-induces-haemorrhage-in-vivo
#5
Tadahiko Seo, Taketo Sakon, Shiori Nakazawa, Asuka Nishioka, Kohei Watanabe, Kaori Matsumoto, Mari Akasaka, Narumi Shioi, Hitoshi Sawada, Satohiko Araki
Snake venom metalloproteases (SVMPs) are members of the a disintegrin and metalloprotease (ADAM) family of proteins, as they possess similar domains. SVMPs are known to elicit snake venom-induced haemorrhage; however, the target proteins and cleavage sites are not known. In this work, we identified a target protein of vascular apoptosis-inducing protein 1 (VAP1), an SVMP, relevant to its ability to induce haemorrhage. VAP1 disrupted cell-cell adhesions by relocating VE-cadherin and γ-catenin from the cell-cell junction to the cytosol, without inducing proteolysis of VE-cadherin...
April 20, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28425161/atorvastatin-treatment-modulates-p16-promoter-methylation-to-regulate-p16-expression
#6
Boqian Zhu, Yaoyao Gong, Gaoliang Yan, Dong Wang, Qingjie Wang, Yong Qiao, Jiantong Hou, Bo Liu, Chengchun Tang
Intimal hyperplasia, the key event of artery restenosis, was a result of cell proliferation and cell migration. Atorvastatin experts an inhibitory effect on cell proliferation and migration but its mechanism remains largely unknown. p16, as a well-known tumor suppressor, was also reported to suppress cell growth and migration, but with vague mechanism. In this study, we demonstrated atorvastatin represses cell proliferation and migration in vascular smooth muscle cells (VSMCs), which process is mediated by p16...
April 20, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28417533/split-tasks-of-asymmetric-nucleotide-binding-sites-in-the-heterodimeric-abc-exporter-efrcd
#7
Lea M Hürlimann, Michael Hohl, Markus A Seeger
Many heterodimeric ATP-binding cassette (ABC) exporters evolved asymmetric ATP-binding sites containing a degenerate site incapable of ATP hydrolysis due to noncanonical substitutions in conserved sequence motifs. Recent studies revealed that nucleotide binding to the degenerate site stabilizes contacts between the nucleotide-binding domains (NBDs) of the inward-facing transporter and regulates ATP hydrolysis at the consensus site via allosteric coupling mediated by the D-loops. However, it is unclear whether nucleotide binding to the degenerate site is strictly required for substrate transport...
April 18, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28398698/inhibiting-epidermal-growth-factor-receptor-signalling-potentiates-mesenchymal-epithelial-transition-of-breast-cancer-stem-cells-and-their-responsiveness-to-anticancer-drugs
#8
Kanakaraju Manupati, Neha R Dhoke, Tanusree Debnath, Ragini Yeeravalli, Kalpana Guguloth, Shahrzad Saeidpour, Utpal Chandra De, Sudhan Debnath, Amitava Das
Recurrence of breast cancer in patients is a persisting challenge to medical fraternity. Breast tumor contains a small population with high tumor initiating and metastatic potential known as Cancer Stem Cells (CSCs) that are resistant to existing chemotherapeutics. CSCs contribute to the aggressiveness of Triple Negative Breast Cancers (TNBCs) thereby necessitates identifying molecular targets on breast CSCs. TNBC cell line MDA-MB-231, as compared to MCF-7 depicted a higher expression of Epidermal Growth Factor Receptor (EGFR)...
April 11, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28391634/chi3l1-regulation-of-inflammation-and-the-effects-on-osteogenesis-in-a-staphylococcus-aureus-induced-murine-model-of-osteomyelitis
#9
Xueqiu Chen, Jian Jiao, XiaoQing He, JianPing Zhang, Hai Wang, YongQing Xu, Tao Jin
Osteomyelitis is an inflammation of the bone and bone marrow that occurs as a consequence of infections mainly attributed to Staphylococcus aureus. In a previous study, we found that expression of the chitinase 3-like 1 (CHI3L1) gene affected mineralization of MC3T3-E1 cells infected with S. aureus and there was increased expression of CHI3L1 in the blood of osteomyelitis patients. In the present study, to further investigate the role of CHI3L1 in osteomyelitis, we developed an S. aureus-induced murine model of the disease...
April 8, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28391618/structural-features-of-aspergillus-niger-%C3%AE-galactosidase-define-its-activity-against-glycoside-linkages
#10
Agustín Rico-Díaz, Mercedes Ramírez-Escudero, Ángel Vizoso-Vázquez, M Esperanza Cerdán, Manuel Becerra, Julia Sanz-Aparicio
β-galactosidases are biotechnologically interesting enzymes that catalyze the hydrolysis or transgalactosylation of β-galactosides. Among them, the Aspergillus niger β-galactosidase (AnβGal) belongs to the glycoside hydrolase family 35 (GH35) and is widely used in the industry due to its high hydrolytic activity degrading lactose. We present here its three-dimensional structure in complex with different oligosaccharides, to illustrate the structural determinants of the broad specificity of the enzyme against different glycoside linkages...
April 8, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28391610/essential-amino-acid-mixtures-drive-cancer-cells-to-apoptosis-through-proteasome-inhibition-and-autophagy-activation
#11
Laura Bonfili, Valentina Cecarini, Massimiliano Cuccioloni, Mauro Angeletti, Vincenzo Flati, Giovanni Corsetti, Evasio Pasini, Francesco S Dioguardi, Anna Maria Eleuteri
Cancer cells require both energy and material to survive and duplicate in a competitive environment. Nutrients, such as amino acids (AAs), are not only a caloric source, as they can modulate cell metabolism and modify hormones homeostasis. Our hypothesis is that the environmental messages provided by AAs rule the dynamics of cancer cells life or death, and the alteration of the balance between essential (EAAs) and non-essential amino acids (NEAAs) (lower and higher than 50%, respectively) present in nutrients may represent a key instrument to alter environment-dependent messages thus mastering cancer cells destiny...
April 8, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28390082/the-background-puzzle-how-identical-mutations-in-the-same-gene-lead-to-different-disease-symptoms
#12
REVIEW
Jan E Kammenga
Identical disease-causing mutations can lead to different symptoms in different people. The reason for this has been a puzzling problem for geneticists. Differential penetrance and expressivity of mutations has been observed within individuals with different, and those with similar, genetic backgrounds. Attempts have been made to uncover the underlying mechanisms that determine differential phenotypic effects of identical mutations, through studies of model organisms. From these studies evidence is accumulating that to understand disease mechanism or predict disease prevalence an understanding of the influence of genetic background is as important as the putative disease causing mutations of relatively large effect...
April 8, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28383827/adp-ribosylation-new-facets-of-an-ancient-modification
#13
REVIEW
Luca Palazzo, Andreja Mikoč, Ivan Ahel
Rapid response to environmental changes is achieved by uni- and multicellular organisms through a series of molecular events, often involving modification of macromolecules, including proteins, nucleic acids and lipids. Amongst these, ADP-ribosylation is of emerging interest because of its ability to modify different macromolecules in the cells, and its association with many key biological processes, such as DNA-damage repair, DNA replication, transcription, cell division, signal transduction, stress and infection responses, microbial pathogenicity and aging...
April 6, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28380286/folding-of-proteins-with-a-flavodoxin-like-architecture
#14
REVIEW
Joseline A Houwman, Carlo P M van Mierlo
The flavodoxin-like fold is a protein-architecture that can be traced back to the universal ancestor of the three kingdoms of life. Many proteins share this α-β parallel topology and hence it is highly relevant to illuminate how they fold. Here, we review experiments and simulations concerning the folding of flavodoxins and CheY-like proteins, which share the flavodoxin-like fold. These polypeptides tend to temporarily misfold during unassisted folding to their functionally active forms. This susceptibility to frustration is caused by the more rapid formation of an α-helix compared to a β-sheet, particularly when a parallel β-sheet is involved...
April 5, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28374568/inflammasome-activation-by-nucleic-acids-and-nucleosomes-in-sterile-inflammation%C3%A2-or-is-it-sterile
#15
Christopher R Lupfer, Angeline Rodriguez, Thirumala-Devi Kanneganti
Inflammasomes are multiprotein complexes that form in the cytoplasm in response to cellular damage and cytosolic pathogen-associated molecules during infection. These complexes play important roles in initiating innate and adaptive immune responses to infectious disease. In addition, inflammasomes are now recognized as important mediators of sterile inflammation in various autoimmune and autoinflammatory diseases. Interestingly, microbiota and infection play critical roles in the development of "sterile inflammation"...
April 4, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28374518/neutrophil-extracellular-traps-can-serve-as-platforms-for-processing-and-activation-of-il-1-family-cytokines
#16
Danielle M Clancy, Conor M Henry, Graeme P Sullivan, Seamus J Martin
Activated neutrophils can undergo a mode of regulated cell death, called NETosis, that results in the extrusion of chromatin into the extracellular space, thereby acting as extracellular traps for microorganisms. Neutrophil-derived extracellular traps (NETs) are comprised of DNA decorated with histones, antimicrobial proteins and neutrophil granule proteases, such as elastase and cathepsin G. NET-associated factors are thought to enhance the anti-microbial properties of these structures and localisation of anti-microbial molecules on NETs may serve to increase their local concentration...
April 4, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28371548/characterization-of-the-first-naturally-thermostable-terpene-synthases-and-development-of-strategies-to-improve-thermostability-in-this-family-of-enzymes
#17
Matthew Q Styles, Edward A Nesbitt, Scott Marr, Marc Hutchby, David J Leak
The terpenoid family of natural products are being targeted for heterologous microbial production as a cheaper and more reliable alternative to extraction from plants. The key enzyme responsible for diversification of terpene structure is the class-I terpene synthase, and these often require engineering to improve properties such as thermostability, robustness and catalytic activity before they are suitable for industrial use. Improving thermostability typically relies on screening a large number of mutants, as there are no naturally thermostable terpene synthases described upon which to base rational design decisions...
March 31, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28371406/in-vitro-generation-of-polysialylated-cervical-mucins-by-bacterial-polysialyltransferases-to-counteract-cytotoxicity-of-extracellular-histones
#18
Sebastian P Galuska, Christina E Galuska, Tharmala Tharmalingam, Kristina Zlatina, Gerlinde Prem, Farzali C O Husejnov, Pauline M Rudd, Willie F Vann, Colm Reid, Justine Vionnet, Mary E Gallagher, Faye A Carrington, Sarah-Louise Hassett, Stephen D Carrington
Neutrophil extracellular traps (NET) are formed against pathogens. However, various diseases are directly linked to this meshwork of DNA. The cytotoxic properties of extracellular histones especially seem to be an important trigger during these diseases. Furthermore, NET accumulation on implants is discussed to result in an impaired efficiency or failure, depending on the category of implant. Interestingly, mucins have been investigated as surface coatings potentially capable of reducing neutrophil adhesion...
March 31, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28371378/caspases-rule-the-intracellular-trafficking-cartel
#19
REVIEW
Catherine Duclos, Christine Lavoie, Jean-Bernard Denault
During apoptosis, caspases feast on several hundreds of cellular proteins to orchestrate rapid cellular demise. Indeed, caspases are known to get a taste of every cellular process in one way or another, activating some, but most often shutting them down. Thus, it is not surprising that caspases proteolyze proteins involved in intracellular trafficking with particularly devastating consequences for this important process. This review article focuses on how caspases target the machinery responsible for smuggling goods within and outside the cell...
March 31, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28342295/intraflagellar-transport-mechanisms-of-motor-action-cooperation-and-cargo-delivery
#20
REVIEW
Bram Prevo, Jonathan M Scholey, Erwin J G Peterman
Intraflagellar transport (IFT) is a form of motor-dependent cargo transport that is essential for the assembly, maintenance, and length control of cilia, which play critical roles in motility, sensory reception, and signal transduction in virtually all eukaryotic cells. During IFT, anterograde kinesin-2 and retrograde IFT dynein motors drive the bidirectional transport of IFT trains that deliver cargo, for example, axoneme precursors such as tubulins as well as molecules of the signal transduction machinery, to their site of assembly within the cilium...
March 25, 2017: FEBS Journal
journal
journal
40797
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"