Serum irisin levels in polycystic ovary syndrome after ovarian drilling.

BACKGROUND: Many cases of Poly-Cystic Ovary Syndrome (PCOS) are overweight and presenting with insulin resistance.

MAIN OBJECTIVE: was to evaluate the effects of ovarian drilling on the serum levels of Irisin in women with polycystic ovaries.

STUDY DESIGN AND SETTING: Serum Irisin levels were investigated in 100 cases with PCOS before ovarian drilling and 3 months after drilling, and in 80 control cases. Serum Irisin, hormonal profile and HOMA-IR were estimated in PCOS cases before and after ovarian drilling. Statistical analysis was performed by using Statistical Package for Social Scientists (SPSS).

RESULTS: The serum irisin levels in overweight and in normal weight PCOS cases before ovarian drilling were significantly higher as compared with the corresponding control cases. Fasting serum Irisin levels were found to be significantly elevated in PCOS patients before ovarian drilling as compared to the levels after drilling. The serum irisin levels in overweight and in normal weight PCOS cases before ovarian drilling were found to be significantly positively correlated with BMI, insulin levels, and HOMA-IR.

CONCLUSION: Elevated serum Irisin levels in PCOS may contribute to the development of insulin resistance. Ovarian drilling for polycystic ovaries results in a significant decrease in the serum Irisin levels. The analysis of ROC curves may suggest that serum Irisin may be a valuable biomarker for diagnosis and for monitoring cases with PCOS during treatment.