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Diabetes & Metabolic Syndrome

Armindo Sousa Ribeiro, Rui Seixas, Juan Manuel Gálvez, Vicente Climent
AIMS: The primary objective of our study is to determine the prevalence of the metabolic syndrome in the population. The secondary objective is to determine the prevalence of cardiovascular risk factors, anthropometric alterations and the prevalence of target organ damage and their relationship with aging. MATERIAL AND METHODS: The sample for the study was obtained by means of a consecutive population-based demonstration in 803 adults over 18 years of age belonging to the labor force of the company Grupo Delta SA...
May 16, 2018: Diabetes & Metabolic Syndrome
Samar Abu Rkhaya, Nailya Bulatova, Violet Kasabri, Randa Naffa, Reema Alquoqa
BACKGROUND: Sirtuin 1 (SIRT 1) and malondialdehyde (MDA) were implicated in metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM) pathophysiology. AIMS AND METHODS: This cross-sectional study aimed to investigate both SIRT 1 and MDA in 30 lean healthy control, 31 normoglycemic MetS subjects and 30 MetS-Pre/T2DM drug naïve. C orrelation studies were established for both biomarkers with adiposity indices [conicity index (CI), waist circumference (WC), weight-to-height (WHtR) ratio, weight-to-hip (WHR) ratio, hip circumference (HC), and body adiposity index (BAI)], hematological indices [red cell distribution width (RDW), mean platelet volume (MPV), platelet-to-lymphcyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR)] and atherogenicity indices (atherogenicity index of plasma (AIP = log10 TG/HDL-C ratio), TC/HDL-C and LDL-C/HDL-C ratios]...
May 15, 2018: Diabetes & Metabolic Syndrome
Rajendran Jayanthi, Abu Raghavan Srinivasan, Gopal Niranjan
BACKGROUND: Insulin resistance with altered thyroid status in women is observed in type 2 diabetics and varies with advancing age and estrogen profile. We compared thyroid status between premenopausal and postmenopausal women in obese, non obese and overweight type 2 diabetes. METHODOLOGY: We included 301type 2 diabetics who were segregated into premenopausal (n = 100) 33.2% and postmenopausal (n = 201) 66.8% among three sub groups (Non obese, overweight and Obese)...
May 10, 2018: Diabetes & Metabolic Syndrome
Reem M Al Haj Ahmad, Hayder A Al-Domi
INTRODUCTION: Dementia and type 2 diabetes mellitus (T2DM) are two of the epidemics of our time; in which insulin resistance (IR) is playing the central role. Epidemiological studies found that different types of dementia development may be promoted by the presence of T2DM. OBJECTIVES: We aimed in this review to highlight the role of insulin and the IR in the brain as a pathophysiological factor of dementia development and also to expand our understanding of T2DM as a mediator of IR in the brain and to review the possible mechanisms of action that may explain the association...
May 6, 2018: Diabetes & Metabolic Syndrome
Kuppuswami Jayashree, Md Yasir, Gandhipuram Periyasamy Senthilkumar, K Ramesh Babu, Vadivelan Mehalingam, Palani Selvam Mohanraj
AIMS: Diabetic Retinopathy (DR) is the leading cause of vision loss in the working age population. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1), are molecules involved in extracellular tissue matrix remodelling. They are implicated in the loss of retinal tissue integrity, a major cause of DR, that leads to retinal tissue degradation and apoptosis. This study is therefore, conducted to compare the serum levels of MMP-9 and TIMP-1 in T2DM patients without and with retinopathy, and to evaluate their association with the severity of DR...
May 5, 2018: Diabetes & Metabolic Syndrome
Meenal Dhall, Kshetrimayum Surmala Devi, Nilupher, Urvashi Gupta, Renu Tyagi, Satwanti Kapoor
AIM: Study aims to assess the association of various adiposity markers with blood pressure levels. STUDY DESIGN: The present study was a cross-sectional study conducted in Delhi. A total of 568 (males- 250, females- 318) participants aged 20-55 years were enrolled for the study. RESULT: Mean height (167.35 ± 7.59) and weight (73.76 ± 15.08) was found to be significantly higher in males. Mean values of minimum waist circumference (183...
May 5, 2018: Diabetes & Metabolic Syndrome
Anahita Ebrahimpour, Mostafa Vaghari-Tabari, Durdi Qujeq, Soheila Moein, Zoleikha Moazezi
BACKGROUND: Subclinical hypothyroidism known as mild thyroid disorder without significant sign and symptoms. The correlation between subclinical hypothyroidism and some of cardiovascular disease risk factors such as serum lipids, homocysteine levels and also insulin resistance index is not well established and the current study was conducted to clarify this issue. METHODS AND MATERIALS: Seventy four patients with mild elevation in levels of thyroid stimulating hormone (TSH) along with normal levels of T3 and T4 were selected as patients group and 74 age and sex matched individuals were selected as healthy control group...
May 5, 2018: Diabetes & Metabolic Syndrome
Alicia Halikas, Kelly J Gibas
Diabetics in mid-life carry a 1.5 times higher risk of developing Alzheimer's disease than those diagnosed with diabetes (T2D) later in life [1]. Recent research points to accelerated cognitive decline within a range of 20%-50% for middle-aged diabetics as compared to non-diabetic populations [2,3]. Metabolic syndrome (MetS), a type 2 diabetes (T2D) precursor, is also linked to MCI and AD pathologies via hypo-metabolic brain circuitry that inhibits glucose metabolism and attenuates cognitive function [4]. Dysregulation of intracellular and extracellular signaling as mediated by the mTOR and AMPK pathways is the result...
April 27, 2018: Diabetes & Metabolic Syndrome
Farbod Ebadi Fardazar, Farzaneh Tahari, Mahnaz Solhi
AIMS: Diabetic foot is one of the most serious and costly complications of diabetes. Empowerment is an important indicator in promoting foot care behaviors that helps patients to use their maximum abilities. This study was carried out with the aim of empowering patients with type 2 diabetes to prevent diabetic foot in the city of Fuladshahr, Isfahan, Iran. METHODS: This is a quasi-experimental study. 104 eligible patients were randomly assigned to two groups: intervention group and control group...
April 26, 2018: Diabetes & Metabolic Syndrome
Omid Sadeghi, Ammar Hassanzadeh Keshteli, Farideh Doostan, Ahmad Esmaillzadeh, Peyman Adibi
AIM: To assess the association of dairy consumption and dietary calcium intake with general and abdominal obesity in a large sample of Iranian adults. METHODS: In this cross-sectional study, dairy consumption and dietary calcium intake were assessed using a validated dish-based 106-item semi-quantitative food frequency questionnaire in 6582 Iranian adults aged 18-55 years living in Isfahan. A self-administered validated questionnaire was used to collect data on anthropometric measures...
April 25, 2018: Diabetes & Metabolic Syndrome
Lobna F El Toony, Dina Ali Hamad, Omar Mohammed Omar
BACKGROUND: Ramadan fasting is associated with the risk of acute complications including hypoglycaemia. Therefore, patients' education before Ramadan and follow up during Ramadan is essential for safe fasting. OBJECTIVES: To evaluate the effect of pre-Ramadan education program on biochemical parameters and the risk of hypoglycaemia in patients with type 2 diabetes mellitus. METHODS: A prospective interventional controlled design was carried out on 320 Muslim patients with type 2 diabetes...
April 25, 2018: Diabetes & Metabolic Syndrome
Sintayehu Asaye, Shiferaw Bekele, Daniel Tolessa, Waqtola Cheneke
BACKGROUND: Metabolic syndrome is a multisystem disorder which coined to describe the recognized clustering of metabolic and cardiovascular abnormalities including obesity, hypertension, dyslipidemia, and abnormalities of glucose homeostasis. OBJECTIVE: To assess the prevalence and associated factors of metabolic syndrome among psychiatric patients in Jimma University Specialized Hospital. METHODS: This study was conducted at Jimma University Specialized hospital psychiatric ward from May 15 to July 16, 2015...
April 24, 2018: Diabetes & Metabolic Syndrome
Heitham Awadalla, Ahmed O Almobarak, Mohamed H Ahmed
INTRODUCTION: Smoking cigarettes and diabetes are major public health problems in Sudan. Smoking is associated with insulin resistance and can be associated with type 2 diabetes. The aim of this study was to investigate the prevalence of smoking in individuals with diabetes and associated complications. METHODOLOGY: a descriptive analytical cross-sectional study, included 315 of participants with diabetes. The data collection was performed to gather demographic information, prevalence of smoking and presence of complications...
April 24, 2018: Diabetes & Metabolic Syndrome
Anthony P Sunjaya, Angela F Sunjaya
AIMS: To compare uric acid, lipid, and kidney profile along with management and complications of Indonesian diabetic patients with good and poor glycemic control based on glycated hemoglobin profile. MATERIALS AND METHODS: Data was obtained from medical records of Internal Medicine Clinic in Hermina Podomoro General Hospital for the period January-December 2015. Subjects were grouped into good and poor glycemic control groups based on their glycated hemoglobin (HbA1c) levels...
April 24, 2018: Diabetes & Metabolic Syndrome
Yat Yen, Yumin Shi, Bunly Soeung, Ratny Seng, Channy Dy, Rathny Suy, Kimlong Ngin
PURPOSE: Overweight and underweight are one of the leading risk factors for non-communicable diseases (NCDs), but little research on this area has been undertaken in Cambodia. Therefore, this study aimed to measure underweight and overweight and their associated risk behaviors among Cambodian high school students. METHODS: 3806 students (mean ag = 15.65 years, SD = 1.80, age range = 11-18 years) from the 2013 Cambodia-Global School-based Student Health Survey were used to yield representative samples of the Cambodian students...
April 21, 2018: Diabetes & Metabolic Syndrome
Nervana M K Bayoumy, Mohamed M El-Shabrawi, Soha Younes, Hamdy H Omar
BACKGROUND: Metabolic syndrome (MS) is considered one of the major worldwide epidemics. It accounts for billions of cardiovascular disease events and deaths. Till now, major basics of MS are not fully clarified. Peroxisome Proliferator-Activated Receptor-α (PPARα) displays a ligand-activated transcription factor. It is involved in the regulation of many metabolic processes including inflammation, lipid, and glucose metabolism. Therefore, this study investigated the leucocytic expression of PPARα in a metabolic patient in comparison to healthy controls...
April 21, 2018: Diabetes & Metabolic Syndrome
Mohsen Janghorbani, Nouralddin Soltanian, Masoud Amini, Ashraf Aminorroaya
BACKGROUND: Studies reported that lipid-lowering treatment may increase the risk of diabetes, support the hypothesis that low-density lipoprotein cholesterol (LDLC) may be associated with type 2 diabetes (T2D). OBJECTIVE: The aim of this study was to assess the association between the LDLC levels and the incidence of T2D in an Iranian high-risk population not treated with lipid-lowering medications. METHODS: Mean 10-year follow-up data (1819) in non-diabetic first-degree relatives (FDR) of consecutive patients with T2D 30-70 years old, who were not treated with lipid-lowering drugs at baseline were examined...
April 21, 2018: Diabetes & Metabolic Syndrome
Ferdos Zaman, Sedigheh Nouhjah, Hajieh Shahbazian, Nahid Shahbazian, Seyed Mahmoud Latifi, Alireza Jahanshahi
AIMS: Early identification of at-risk groups is an important step in preventing gestational diabetes and its subsequent side effects. This study aimed to evaluate the risk factors of gestational diabetes based on the International Association of Diabetes and Pregnancy Study Groups criteria in Ahvaz. MATERIAL AND METHODS: In a cross-sectional case control study, 520 pregnant women involving life after gestational diabetes Ahvaz cohort study (LAGAs) were investigated for risk factors of gestational diabetes mellitus...
April 21, 2018: Diabetes & Metabolic Syndrome
Dawson Brown, Kelly J Gibas
A vast amount of research has been done on the APOE4 genetic marker for Alzheimer's disease (AD), but its connection to metabolic processes associated with peripheral insulin resistance and cerebral glucose metabolism is still relatively unknown. The APOE4 allele is the strongest genetic risk factor for developing late-onset Alzheimer's disease, particularly in individuals who have inherited two copies of the gene (Zhao et al., 2017). In this case study, a 38 year old male with metabolic syndrome (MetS), the APOE4 gene, early stage memory problems and a family history of Alzheimer's Disease (AD) was placed on a ketogenic diet combined with high intensity interval training (HIIT) for 10 weeks...
April 20, 2018: Diabetes & Metabolic Syndrome
Ranil Jayawardena, Priyanga Ranasinghe, Tharindu Chathuranga, Piyusha Milani Atapattu, Anoop Misra
Yoga is increasingly used as an adjunctive therapy in the management of Type-2 Diabetes Mellitus (T2DM). The present study aims to systematically evaluate the literature and perform a meta-analysis on the effects of yoga practice compared to physical exercise in the management of T2DM. Data were obtained using a stepwise search process using keywords in the following online medical databases; PubMed, Web of Science and Scopus. All controlled clinical trials involving patients with T2DM, comparing yoga as an intervention with physical exercise and evaluating glycaemic control and other outcomes between the intervention and control groups were included in the analysis...
April 18, 2018: Diabetes & Metabolic Syndrome
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