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Diabetes & Metabolic Syndrome

Firass Abiad, Dalia Khalife, Bassem Safadi, Ramzi Alami, Johnny Awwad, Fatin Khalifeh, Ghina Ghazeeri
AIM: The aims of this study is to address the improvement in CRP and adiponectin in obese PCOS and non PCOS after bariatric surgery, and to show that obese PCOS women have a slower rate of improvement when compared to obese non PCOS women. METHODS: This is a prospective case-control study evaluating the effect of weight loss by sleeve gastrectomy among obese PCOS patients. RESULTS: There was a 36.28% of weight loss among obese PCOS and 33...
November 2018: Diabetes & Metabolic Syndrome
Anneh Mohammad Gharravi, Alireza Jafar, Mehrdad Ebrahimi, Ahmad Mahmodi, Erfan Pourhashemi, Nasrin Haseli, Niloofar Talaie, Parinaz Hajiasgarli
Diabetes mellitus (DM) remains the 7th leading cause of death in the world. Daily insulin injection is one component of a treatment plan for people with Diabetes mellitus type 1 (T1DM) that restores normal or near-normal blood sugar levels. However, Insulin treatment depends upon a variety of individual factors and leads to poor and drastic glycemic control. The need for an effective cell replacement strategy will be the aim of future clinical trials. Therefore, the aim of this systematic review is to outline the latest advances in scaffolding and stem cell therapy as a non-pharmacologic treatment for T1DM...
November 2018: Diabetes & Metabolic Syndrome
Yasser Mostafa Hafez, Omnia Safwat El-Deeb, Marwa Mohamed Atef
BACKGROUND: Diabetic foot ulceration (DFU) is a serious diabetic complication that can progress to amputation and since SIRT1 regulates glucose metabolism, inflammation, and oxidative stress which are the major contributors in diabetic complications, So we aimed to discuss its role as an epigenetic biomarker in DFU and highlight its link to oxidative stress and inflammatory cytokines. METHOD: 60 DM patients were enrolled in the study, 30 without DFU and 30 with DFU in addition to 15 healthy subjects (control group)...
November 2018: Diabetes & Metabolic Syndrome
Tarek Mohamed Ali, Ahmad El Askary
BACKGROUND: Inconsistent results have been described regarding the part of fetuin-A and testosterone in arterial stiffness in type 2 diabetes mellitus (T2DM). AIM: To look into the links of serum fetuin-A and testosterone levels with brachial-Ankle pulse wave velocity (baPWV), a marker of arteriosclerosis and common carotid intima media thickness (ccIMT), a marker of early atherosclerosis, in diabetic Saudi men patients. SUBJECTS AND METHODS: One hundred and fifty adult male patients with T2DM and 60 non-diabetic control subjects were enrolled from different Saudi Arabia Taif hospitals...
November 2018: Diabetes & Metabolic Syndrome
Leila Yazdanpanah, Hajieh Shahbazian, Iraj Nazari, Saeed Hesam, Fatemeh Ahmadi, Bahman Cheraghian, Hamid Reza Arti, Seyed Ehsan Mohammadianinejad
AIMS: This study was done to assess the risk factors associated with diabetic foot ulcer-free survival in patients with diabetes. MATERIALS AND METHODS: Based on a prospective cohort study, ADFC (Ahvaz Diabetic Foot Cohort) study, carried out in a university hospital, all of the patients with diabetes were followed up for new diabetic foot ulcer (DFU). The time of ulcer development was final outcome during two years in the present study. To analyze the data, the variables were first evaluated by univariate analysis...
November 2018: Diabetes & Metabolic Syndrome
Yen Ping Ng, Ramadan Ahmed, Guat See Ooi, Chia Ying Lau, Ganesh Pandian Balasubramanian, Cheng Hoon Yap
INTRODUCTION: In Malaysia, 61% of dialysis cases are secondary to diabetes. To date, we are still lacking of data on the rate of progression of type 2 diabetes mellitus (T2DM) to end stage renal disease (ESRD) in Malaysia. MATERIALS AND METHODS: This was a retrospective study conducted at nephrology unit of a tertiary hospital in Kedah. All diabetic ESRD patients who fulfilled the inclusion criteria were identified and recruited for analysis. RESULTS: The mean duration of DM to ESRD was found to be 14...
November 2018: Diabetes & Metabolic Syndrome
Ichiro Wakabayashi
AIMS: Cardiometabolic index (CMI), calculated as the product of waist-to-height ratio and triglycerides-to-HDL cholesterol ratio, has been proposed as a discriminator of diabetes and has been reported to be associated with progression of atherosclerosis. The purpose of this study was to determine the relationship between alcohol drinking and CMI in men with diabetes. METHODS: The subjects were Japanese male workers aged from 35 to 65 years with diabetes mellitus (n = 1411)...
November 2018: Diabetes & Metabolic Syndrome
Kalyan Goswami, Mahendra Gandhe
The evolution of human from ancient times to modern era has witnessed several environmental and social changes which contributed to genetic and epigenetic makeup of human beings and in turn is responsible for its present phenotype. In the recent past, owing to socioeconomic developmental pressure, a large epidemiologic shift towards non-communicable disease pattern has been noticed in many developing countries including India which resulted into incidence of diabetes and cardiovascular diseases in epidemic proportion...
November 2018: Diabetes & Metabolic Syndrome
Eloísa Urrechaga
AIMS: Hemoglobin A1c (HbA1c) is gold-standard for the assessment of glycemic control in diabetic patients. Previous studies have reported that iron deficiency may elevate A1c concentrations, independent of glycemia. This study aimed to analyze the effect of iron status on HbA1c levels in diabetic patients. METHODS: 661 patients 336 females (228 menopausal and 108 premenopausal) and 325 males (237 age> 50 years and 88 age < 50 years) were recruited. HbA1c, ferritin, fasting plasma glucose, hemogram and medical history were recorded...
November 2018: Diabetes & Metabolic Syndrome
Farbod Ebadifard Azar, Mahnaz Solhi, Fatemeh Darabi, Alireza Rohban, Mitra Abolfathi, Nazila Nejhaddadgar
AIMS: Diabetes mellitus is a chronic and progressive disease which requires ongoing medical care as well as patient's self-care skills to prevent acute complications. The purpose of this study is to determine the effect of the PRECEDE-PROCEED model combined with self-management theory on self-care behaviors in type 2 diabetic patients. METHODS: In this semi-experimental study, 86 type 2 diabetic patients referred to the diabetes clinic of Ardabil were randomly selected and divided into two groups (n = 43)...
November 2018: Diabetes & Metabolic Syndrome
Yasir Faraz Abbasi, Ooi Guat See, Ng Yen Ping, Ganesh Pandian Balasubramanian, Yap Cheng Hoon, Sireesha Paruchuri
Diabetes is among leading public health concerns in Malaysia due to premature and preventable mortality involving macro and microvascular complications. Diabetes knowledge, attitude, and practice (KAP) are vital in diabetes management. The present study assessed the level of diabetes KAP among type 2 diabetes patients with associated and correlated factors through a self-administered questionnaire-based study on a convenience sample of 386 type 2 diabetes mellitus patients in Kuala Muda District, Kedah, Malaysia...
November 2018: Diabetes & Metabolic Syndrome
Niloufar Rasaei, Atieh Mirzababaei, Hana Arghavani, Somayeh Tajik, Seyed Ali Keshavarz, Mir Saeed Yekaninejad, Hossein Imani, Khadijeh Mirzaei
AIM: Metabolically Healthy Obese (MHO) is called to obese people that their insulin sensitivity, lipid profiles and inflammatory profiles are favorable, and there are no signs of hypertension and cardio-metabolic diseases. The metabolically unhealthy obese (MUHO) is the opposite. A Body Shape Index (ABSI) is a marker to identifying abdominal obesity that is derived from weight, height and waist circumference (WC). Several studies have reported ABSI is associated with diabetes, metabolic syndrome, hypertension and higher mortality rate...
November 2018: Diabetes & Metabolic Syndrome
David M Williams, Natasha Shrikrishnapalasuriyar, Waheeba Syed, Win L Yin, Richard Chudleigh, Stephen C Bain, David E Price, Jeffrey W Stephens
AIMS: Xultophy is the first fixed co-formulation pen containing insulin degludec and the glucagon-like peptide-1 (GLP-1) analogue liraglutide, authorized for type 2 diabetes patients since 2014. The aim was to review the clinical effectiveness of Xultophy across two hospitals in Wales. METHODS: Retrospective review of patients commenced on Xultophy between April 2016 and January 2018 was taken. Data related to glycemic control, weight and medication use were collected...
November 2018: Diabetes & Metabolic Syndrome
Elaheh Rashidbeygi, Mohammad Hossein Rahimi, Mehdi Mollahosseini, Mir Saeed Yekaninejad, Hossein Imani, Zhila Maghbooli, Khadijeh Mirzaei
BACKGROUND: Recent studies have shown that Vitamin D deficiency is very common globally. Vitamin D deficiency is associated with lipid metabolism. A relationship between vitamin D levels and waist circumference (WC) has been observed. The purpose of this study is to evaluate the relationship between vitamin D status and metabolic dyslipidemia and the hypertriglyceridemic waist phenotype. METHODS: This cross-sectional study was conducted on 265 healthy Tehran adults...
November 2018: Diabetes & Metabolic Syndrome
Marie Doualla-Bija, Yonathan Lobe Batchama, Jude Moutchia-Suh, Vicky Joceline Ama Moor, Félicité Kamdem, Fernando Kemta Lekpa, Henry Luma Namme
BACKGROUND: Evidence from epidemiological studies suggests an important association between gout and the metabolic syndrome (MetS). However, to the best of our knowledge, prevalence of metabolic syndrome in gout has not been reported in sub-Saharan African (SSA) settings. OBJECTIVES: The aim of this study was to determine the prevalence and characteristics of MetS in gout in a SSA population. METHOD: After prior ethical clearance, we carried out a cross-sectional study involving gout patients in a referral hospital in Douala-Cameroon...
November 2018: Diabetes & Metabolic Syndrome
Salwa S Hosny, Meram M Bekhet, Hayam A Hebah, Nagwa R Mohamed
BACKGROUND: Diabetes mellitus is the leading cause of end stage renal disease worldwide. Early identification of diabetic nephropathy even before appearance of microalbuminuria is a challenge for early prevention of occurrence and progression of this complication. Neutrophil gelatinase-associated lipocalin is a small protein that belongs to the lipocalin protein. Urinary neutrophil gelatinase-associated lipocalin is a promising early marker in different renal problems. AIM OF THE WORK: To measure urinary neutrophil gelatinase-associated lipocalin in type 2 diabetic patients and to assess its role as an early marker for diagnosis of diabetic nephropathy and diabetic retinopathy...
November 2018: Diabetes & Metabolic Syndrome
Heitham Awadalla, Sufian K Noor, Wadie M Elmadhoun, Sarra O Bushara, Ahmed O Almobarak, Amel Abdalrhim Sulaiman, Mohamed H Ahmed
BACKGROUND: Diabetes mellitus (DM) is a major health problem in Sudan and is a leading cause of morbidity and mortality. Dyslipidemia is a major complication of diabetes and an important risk factor for cardiovascular disease (CVD). The objective of this study was to determine the prevalence of dyslipidemia and its co-relation with the glycemic control in individuals with diabetes in River Nile State, Sudan. METHODS: Individuals with diabetes attended, Naserudin Karamalla Diabetic (NKDM) Centre, in Atbara teaching hospital during study period, who volunteered to participate were included...
November 2018: Diabetes & Metabolic Syndrome
Anthony P Sunjaya, Angela F Sunjaya
AIMS: To compare the clinical and glycemic profile as well as pregnancy complications and infant mortality among diabetic mothers in Indonesia. MATERIALS AND METHODS: Data was obtained from medical records of Internal-Medicine Clinic in Hermina Podomoro General Hospital during the period January-December 2015. Subjects were grouped into good and poor outcome groups based on infant mortality. RESULTS: Forty-five subjects were obtained with an average age of 31 years, 41 had gestational diabetes mellitus while 4 had pregestational diabetes...
November 2018: Diabetes & Metabolic Syndrome
K Hajian-Tilaki, B Heidari
BACKGROUND: Several abdominal obesity measures have been used for prediction of 10-year cardiovascular disease (CVD) risk but the superiority of these measures remains controversial. The objective of this study was to assess the predictive ability of abdominal obesity measures for risk of CVD events in an Iranian adult population. METHODS: We analyzed the data of population based cross-section study of 567 representative samples of adult population aged 40-70 years in Babol, the north of Iran...
November 2018: Diabetes & Metabolic Syndrome
M Mahmoud Abdel-Rahim, M Mostafa Magdy, A Abdel-Maksoud Mohamad
OBJECTIVE: Comparative study between the effect of LSG and LMGB on patients with type 2 DM and BMI ≥ 35 kg/m2 . STUDY DESIGN: A prospective comparative study which included 40 obese patients with type 2 DM(20 patients were operated for laparoscopic sleeve gastrectomy (LSG) and 20 patients for laparoscopic mini-gastric bypass (LMGB)), with mean age at LSG group 42.95 ± 7.63 with range of 31-59 years, at LMGB group was 42.9 ± 6.17 with range of 34-58 years...
November 2018: Diabetes & Metabolic Syndrome
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