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Diabetes & Metabolic Syndrome

H M M Herath, T P Weerarathna, C L Fonseka, A S Vidanagamage
INTRODUCTION: Recent studies indicate that modulation of post prandial blood sugar (PPBS) plays an important role in the long term glycemic control. Measurement of PPBS is more convenient for patients attending outpatient clinics than fasting blood sugar (FBS) as the former needs only two hours of fasting from the last meal. OBJECTIVE: To assess the value of PPBS monitoring in optimization of long term glycemic control among diabetic patients attending an outpatient clinic...
October 5, 2016: Diabetes & Metabolic Syndrome
Ofer Havakuk, Michal Laufer Perl, Ofir Praisler, Michael Barkagan, Ben Sadeh, Gilad Margolis, Maayan Konigstein, Lilly Veltman Fuks, Gad Keren, Ehud Chorin, Yaron Arbel
BACKGROUND: Metabolic syndrome (MetS) was shown to be related to a variety of diseases. High level of vigilance for the diagnosis of MetS is expected among health providers. We evaluated the level of awareness to MetS among physician and nurses working in a central hospital. METHODS AND RESULTS: A specially designed anonymous questionnaire was used, including both open and multiple choice questions set to evaluate the participant's awareness to MetS. The study included 126 participants, 71% physicians and 29% nurses...
September 21, 2016: Diabetes & Metabolic Syndrome
Ankit Gupta, Herbert F Jelinek, Hayder Al-Aubaidy
This study summarizes major work which investigated the roles of glucagon like peptide-1 (GLP-1) and its receptor (GLP-1R); the use of GLP-1-R agonists and dipeptidyl peptidase 4 inhibitor in the management of type 2 diabetes mellitus. It focuses on the recent therapeutic development which has occurred in this field, and also discusses the potential treatments which can be discovered and implemented in the near future to design an effective therapy for type 2 diabetes mellitus.
September 15, 2016: Diabetes & Metabolic Syndrome
Zahra Rojhani-Shirazi, Fatemeh Barzintaj, Mohamad Reza Salimifard
BACKGROUND: The number of diabetic patients is increasing in the world. Peripheral neuropathy is the most important problem of diabetes. Neuropathy eventually leads to balance impairment which is the main cause of falling down in these patients However, not sufficient evidences available to compare different protocols for improving balance in diabetic patients. OBJECTIVE: This study aimed to compare the effects of two therapeutic exercises on clinical balance measures in patients with type II diabetic peripheral neuropathy...
September 15, 2016: Diabetes & Metabolic Syndrome
Niroomand Mahtab, Hadaegh Farzad, Bahaeddini Mohsen, Darvishi Nakisa
BACKGROUND: Type 2 diabetes is a global problem with significant morbidity and healthcare costs. In this study, we aimed to determine the 10-year trend of diabetes, prediabetes and their risk factors in the adult urban population of Tehran Lipid and Glucose Study (TLGS). MATERIALS AND METHODS: In this cross-sectional study, we included all patients above 20 years of age who were registered in phases 1 and 4 of TLGS. Each phase had a 3-year duration. 4580 patients were recruited in each phase (916 patients in each age-group, including 3772 males and 5145 females)...
September 15, 2016: Diabetes & Metabolic Syndrome
Deepashree Gupta, Meredith Kirn, Zafar A Jamkhana, Richard Lee, Stewart G Albert, Kimberly M Rollins
BACKGROUND: To assess the efficacy of a unified hyperglycemia and diabetic ketoacidosis (DKA) insulin infusion protocol (IIP), based on an Excel algorithm and implemented as an electronic order set, in achieving glycemic targets and minimizing hypoglycemia. METHODS: An IIP was instituted in medical and surgical intensive care units for post-cardiac surgery (PCS) and other stress hyperglycemia (SH), diabetes hyperglycemia (DH), and DKA. The IIP initiated therapeutic insulin rates at elevated blood glucose (BG), and decreased insulin when target range was achieved...
September 15, 2016: Diabetes & Metabolic Syndrome
Abdulbari Bener, Abdulla O A A Al-Hamaq, Eda Merve Kurtulus, Waleed K Abdullatef, Mahmoud Zirie
AIM: The aims of this study were to determine the role of vitamin D, obesity and physical exercise in the regulation of glycemia in Type 2 Diabetes Mellitus patients in a highly consanguineous population. DESIGN: Case and control study. SETTING: The survey was carried out at the Hamad General Hospital and Primary Health Care (PHC) centers in the State of Qatar. SUBJECTS: The study was conducted from November 2012 to June 2014 among subjects above 30 years of age...
October 2016: Diabetes & Metabolic Syndrome
Milind Patil, Jayaprakash Sahoo, Sadishkumar Kamalanathan, Jayakumar Selviambigapathy, Karthik Balachandran, Ritesh Kumar, Muthupillai Vivekanandan, K Ajmal
AIMS: The efficacy of insulin therapy in diabetes depends on proper storage and injection technique. The purpose of this study was to assess the practice of insulin administration among diabetes patients in a tertiary care center. MATERIALS AND METHODS: This observational study was done in Endocrinology department of a tertiary care center during April-June 2015. The consecutive patients using insulin for at least three months by either syringe or pen were recruited...
September 5, 2016: Diabetes & Metabolic Syndrome
Abdulbari Bener, Abdulla O A A Al-Hamaq, Khalid Abdulhadi, Ahmed H Salahaldin, Loida Gansan
AIM: The aim of this study was to determine the prevalence of hearing loss and its association with type 2 diabetes mellitus (T2DM) in a highly endogamous population. DESIGN: This is a cross-sectional study. SETTING: The present study is carried out in Ear Nose Throat (ENT) and Endocrinology outpatient clinics of the Hamad General and Rumeilah Hospitals, Hamad Medical Corporation. SUBJECTS: All subjects aged between 20 and 59 years who visited the Endocrinology and ENT outpatient clinics of the Hamad Medical Corporation with hearing difficulty were included in this study during the period from January 2013 to July 2014...
September 5, 2016: Diabetes & Metabolic Syndrome
Carlos A Peñaherrera, Ruben Peñaherrera, Maria C Duarte, Ernesto Peñaherrera
BACKGROUND: Metabolic syndrome increases cardiovascular risk, and causes damage to the vascular wall. Through this mechanism, it might increase arterial rigidity, leading to further complications and heart strain. The use of a device that measures arterial rigidity can help determine if metabolic syndrome is related to a higher vascular stiffness and changes in estimated arterial age. METHODOLOGY: Cross-sectional study at Luis Vernaza hospital of Guayaquil, Ecuador...
September 5, 2016: Diabetes & Metabolic Syndrome
Ali Reza Soltanian, Shiva Borzouei, Mohammad Afkhami-Ardekan
BACKGROUND: Timely prevention of type 2 diabetes decrease socio-economic burden of disease in a society. To measure people's knowledge, the existence of valid and accurate tool such as questionnaires is very important. In the study we tried to make a comprehensive questionnaire to measure knowledge of apparently healthy individuals. MATERIAL AND METHODS: In this study a questionnaire to assess general population awareness about type II diabetes disease and its complications was Design, developing and validation based on 10 experts' panel and statistical inferences...
September 5, 2016: Diabetes & Metabolic Syndrome
Ali Vasheghani-Farahani, Kaveh Hosseini, Haleh Ashraf, Maryam Abolhasani, Shahrokh Karbalai, Alireza Ghajar, Mohsen Afarideh
INTRODUCTION: Asymptomatic peripheral artery disease (PAD) in symptom-free subjects, and people with the metabolic syndrome (MetS) is a significant correlate of cardiovascular morbidity and mortality. However, little is known about their relationship and whether this is mediated through central obesity as one of the defining components of the MetS. MATERIALS AND METHODS: In a cross-sectional setting, 150 asymptomatic healthy premenopausal women without previously diagnosed hypertension, diabetes or known history cardiovascular diseases were consecutively enrolled...
September 4, 2016: Diabetes & Metabolic Syndrome
Tomoyuki Kawada, Masao Katsumata, Hirofumi Inagaki, Takayuki Nakamura, Yoichi Kon
AIMS: The authors identified the risk of disorders of glucose metabolism (DGM) for sleep-disordered breathing (SDB). METHODS: We conducted a cross-sectional study in 536 men aged 33-84 years. Patients with diabetes medication were excluded for the analysis and DGM were diagnosed by fasting plasma glucose≥100mg/dl and/or 2h plasma glucose ≥140mg/dl. RESULTS: The prevalence of DGM in subjects with and without severe SDB, which was judged by an apnea-hypopnea index (AHI) of 30, were 64...
September 4, 2016: Diabetes & Metabolic Syndrome
Marie-Paule Wautier, Pierre-Jean Guillausseau, Jean-Luc Wautier
Advanced glycation end products (AGE) resulted from a reaction between free amino group of proteins and carbohydrates. This reaction is followed by oxidation and molecular rearrangement. Alternatively AGEs can be produced by glycolysis and oxidation. AGEs bind to a cellular receptor RAGE. RAGE engagement by ligands AGE, β-amyloid peptide, and S100 calgranulin induces a stimulation of NADPH oxidase, reactive oxygen intermediate formation, NFκB activation and gene transcription. This cascade of reaction leads to an inflammatory reaction responsible for alteration of microvessels in the retina and the kidney...
September 4, 2016: Diabetes & Metabolic Syndrome
Manish Bathla, Manpreet Singh, Shazia Anjum, Parmanand Kulhara, Satyarth Jangli
INTRODUCTION AND OBJECTIVE OF THE STUDY: Metabolic syndrome is a combination of insulin resistance, impaired glucose regulation, dyslipidemia, hypertension, microalbuminuria and obesity and this increases the risk for diabetes, myocardial infarction and thus increases the risk of mortality. Substance dependence is considered as a prominent risk factor for metabolic syndrome, but not much work has been done in this field. Thus this study is aimed to know the prevalence of metabolic syndrome in drug naïve substance users...
September 3, 2016: Diabetes & Metabolic Syndrome
Michel P Hermans, K Daniel Amoussou-Guenou, Evariste Bouenizabila, Shaukat S Sadikot, Sylvie A Ahn, Michel F Rousseau
The role of high-density lipoprotein cholesterol (HDL-C) as modifiable risk factor for cardiovascular (CV) disease is increasingly debated, notwithstanding the finding that small-dense and dysfunctional HDL are associated with the metabolic syndrome and T2DM. In order to better clarify the epidemiological risk related to HDL of different size/density, without resorting to direct measures, it would seem appropriate to adjust HDL-C to the level of its main apolipoprotein (apoA-I), thereby providing an [HDL-C/apoA-I] ratio...
September 1, 2016: Diabetes & Metabolic Syndrome
M Mir, A Rostami, M Hormozi
BACKGROUND AND AIM: Interleukin (IL)-18 is a proinflammatory cytokine secreted from mononuclear cells. Serum concentration of IL-18 is a strong predictor of death in patients with cardiovascular diseases. Recent studies have shown that microinflammation is involved in the pathogenesis of diabetic nephropathy as well as of cardiovascular diseases. This study aimed to test the hypothesis that the serum level of IL-18 is a common predictor of nephropathy and atherosclerosis in patients with type 2 diabetes...
August 31, 2016: Diabetes & Metabolic Syndrome
Jatin Agrawal, Veer Bahadur Singh, Babulal Meena, Rajesh Yadav, Mohammad Shareef, Vishnu Saini
INTRODUCTION: Platelets activation and aggregation play fundamental role in thrombotic events in diabetes. MPV marker of platelet activity determines this cardiovascular risk. So by using simple parameter like MPV we can indirectly assess vascular complication in diabetic patient in periphery. AIMS AND OBJECTIVES: Determining MPV of both T1DM and T2DM with their controls and Relation between HbA1C and MPV in Diabetes Mellitus (DM). METHODOLOGY: This cross-sectional study was conducted in department of medicine, SPMC Bikaner from June 2014 - December 2014, included 100 patients attending medical outdoor and 100 healthy matched controls...
August 31, 2016: Diabetes & Metabolic Syndrome
Baris Afsar, Rengin Elsurer
Type 2 diabetes is a global health challenge. In type 2 diabetes both microvascular (nephropathy, retinopathy, neuropathy) and macrovascular complications arise. In kidney, renal pathological changes leading to diabetic nephropathy are mainly secondary to atherosclerosis of the intra and extra renal arteries together with microangiopathy of the glomerular capillaries, afferent arterioles and efferent arterioles. Renal resistive index (RRI) is defined as a ratio of the difference between maximum and minimum (end-diastolic) flow velocity to maximum flow velocity derived from the Doppler measurements of main renal and intrarenal (segmental/interlobar) arteries...
August 30, 2016: Diabetes & Metabolic Syndrome
Mahsa Zare, Shahdokht Rastegar, Esmaeel Ebrahimi, Azade Roohipoor, Saeed Shirali
Today diabetes mellitus is known as main threatening for health society. Beta cells have pivotal role in energy homeostasis by balance in blood glucose. Proliferation and neogenesis are two factors for preservation of beta cell mass but these have lower rate during adulthood rather than neonatal. Beta cell destruction occurs during diabetes that leads to hyperglycemia. Continues production of beta cell is a therapeutic strategy to keep normal blood glucose and pancreatic duct cell can be one of the sources of new beta cells...
August 27, 2016: Diabetes & Metabolic Syndrome
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