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Diabetes & Metabolic Syndrome

Yasir Faraz Abbasi, Ooi Guat See, Ng Yen Ping, Ganesh Pandian Balasubramanian, Yap Cheng Hoon, Sireesha Paruchuri
Diabetes is among leading public health concerns in Malaysia due to premature and preventable mortality involving macro and microvascular complications. Diabetes knowledge, attitude, and practice (KAP) are vital in diabetes management. The present study assessed the level of diabetes KAP among type 2 diabetes patients with associated and correlated factors through a self-administered questionnaire-based study on a convenience sample of 386 type 2 diabetes mellitus patients in Kuala Muda District, Kedah, Malaysia...
July 8, 2018: Diabetes & Metabolic Syndrome
Niloufar Rasaei, Atieh Mirzababaei, Hana Arghavani, Somayeh Tajik, Seyed Ali Keshavarz, Mir Saeed Yekaninejad, Hossein Imani, Khadijeh Mirzaei
AIM: Metabolically Healthy Obese (MHO) is called to obese people that their insulin sensitivity, lipid profiles and inflammatory profiles are favorable, and there are no signs of hypertension and cardio-metabolic diseases. The metabolically unhealthy obese (MUHO) is the opposite. A Body Shape Index (ABSI) is a marker to identifying abdominal obesity that is derived from weight, height and waist circumference (WC). Several studies have reported ABSI is associated with diabetes, metabolic syndrome, hypertension and higher mortality rate...
July 8, 2018: Diabetes & Metabolic Syndrome
David M Williams, Natasha Shrikrishnapalasuriyar, Waheeba Syed, Win L Yin, Richard Chudleigh, Stephen C Bain, David E Price, Jeffrey W Stephens
AIMS: Xultophy is the first fixed co-formulation pen containing insulin degludec and the glucagon-like peptide-1 (GLP-1) analogue liraglutide, authorized for type 2 diabetes patients since 2014. The aim was to review the clinical effectiveness of Xultophy across two hospitals in Wales. METHODS: Retrospective review of patients commenced on Xultophy between April 2016 and January 2018 was taken. Data related to glycemic control, weight and medication use were collected...
June 30, 2018: Diabetes & Metabolic Syndrome
Elaheh Rashidbeygi, Mohammad Hossein Rahimi, Mehdi Mollahosseini, Mir Saeed Yekaninejad, Hossein Imani, Zhila Maghbooli, Khadijeh Mirzaei
BACKGROUND: Recent studies have shown that Vitamin D deficiency is very common globally. Vitamin D deficiency is associated with lipid metabolism. A relationship between vitamin D levels and waist circumference (WC) has been observed. The purpose of this study is to evaluate the relationship between vitamin D status and metabolic dyslipidemia and the hypertriglyceridemic waist phenotype. METHODS: This cross-sectional study was conducted on 265 healthy Tehran adults...
June 28, 2018: Diabetes & Metabolic Syndrome
Marie Doualla-Bija, Yonathan Lobe Batchama, Jude Moutchia-Suh, Vicky Joceline Ama Moor, Félicité Kamdem, Fernando Kemta Lekpa, Henry Luma Namme
BACKGROUND: Evidence from epidemiological studies suggests an important association between gout and the metabolic syndrome (MetS). However, to the best of our knowledge, prevalence of metabolic syndrome in gout has not been reported in sub-Saharan African (SSA) settings. OBJECTIVES: The aim of this study was to determine the prevalence and characteristics of MetS in gout in a SSA population. METHOD: After prior ethical clearance, we carried out a cross-sectional study involving gout patients in a referral hospital in Douala-Cameroon...
June 28, 2018: Diabetes & Metabolic Syndrome
Salwa S Hosny, Meram M Bekhet, Hayam A Hebah, Nagwa R Mohamed
BACKGROUND: Diabetes mellitus is the leading cause of end stage renal disease worldwide. Early identification of diabetic nephropathy even before appearance of microalbuminuria is a challenge for early prevention of occurrence and progression of this complication. Neutrophil gelatinase-associated lipocalin is a small protein that belongs to the lipocalin protein. Urinary neutrophil gelatinase-associated lipocalin is a promising early marker in different renal problems. AIM OF THE WORK: To measure urinary neutrophil gelatinase-associated lipocalin in type 2 diabetic patients and to assess its role as an early marker for diagnosis of diabetic nephropathy and diabetic retinopathy...
June 21, 2018: Diabetes & Metabolic Syndrome
Anthony P Sunjaya, Angela F Sunjaya
AIMS: To compare the clinical and glycemic profile as well as pregnancy complications and infant mortality among diabetic mothers in Indonesia. MATERIALS AND METHODS: Data was obtained from medical records of Internal-Medicine Clinic in Hermina Podomoro General Hospital during the period January-December 2015. Subjects were grouped into good and poor outcome groups based on infant mortality. RESULTS: Forty-five subjects were obtained with an average age of 31 years, 41 had gestational diabetes mellitus while 4 had pregestational diabetes...
June 21, 2018: Diabetes & Metabolic Syndrome
K Hajian-Tilaki, B Heidari
BACKGROUND: Several abdominal obesity measures have been used for prediction of 10-year cardiovascular disease (CVD) risk but the superiority of these measures remains controversial. The objective of this study was to assess the predictive ability of abdominal obesity measures for risk of CVD events in an Iranian adult population. METHODS: We analyzed the data of population based cross-section study of 567 representative samples of adult population aged 40-70 years in Babol, the north of Iran...
June 19, 2018: Diabetes & Metabolic Syndrome
M Mahmoud Abdel-Rahim, M Mostafa Magdy, A Abdel-Maksoud Mohamad
OBJECTIVE: Comparative study between the effect of LSG and LMGB on patients with type 2 DM and BMI ≥ 35 kg/m2 . STUDY DESIGN: A prospective comparative study which included 40 obese patients with type 2 DM(20 patients were operated for laparoscopic sleeve gastrectomy (LSG) and 20 patients for laparoscopic mini-gastric bypass (LMGB)), with mean age at LSG group 42.95 ± 7.63 with range of 31-59 years, at LMGB group was 42.9 ± 6.17 with range of 34-58 years...
June 12, 2018: Diabetes & Metabolic Syndrome
Waleed Sohail, Fatimah Majeed, Amber Afroz
The prevalence of Diabetes Mellitus Type 2 (DM 2) is increasing every passing year due to some global changes in lifestyles of people. The exact underlying mechanisms of the progression of this disease are not yet known. However recent advances in the combined omics more particularly in proteomics and genomics have opened a gateway towards the understanding of predetermined genetic factors, progression, complications and treatment of this disease. Here we shall review the recent advances in proteomics that have led to an early and better diagnostic approaches in controlling DM 2 more importantly the comparison of structural and functional protein biomarkers that are modified in the diseased state...
June 11, 2018: Diabetes & Metabolic Syndrome
Deldar Morad Abdulah, Alan Bapeer Hassan, Farsat Saeed Saadi, Ary Habeeb Mohammed
OBJECTIVES: Dietary and physical activity advice have been considered to be seminal ingredients in prevention and management of type 2 diabetes mellitus. In this regard, the impacts of a three-month self-management intervention on glycemic control in patients with type 2 diabetes were examined in the present study. STUDY DESIGN: A Double-arm post-test intervention study. METHODS: In the current post-test intervention study, three two-hour educational sessions on dietary habits and physical activity designed according to Health Belief Model were presented to 16 non-complicated type 2 diabetic patients and their dietary, physical activities, and biochemical outcomes were compared to a 23 patient-control arm in Iraq in 2017...
June 7, 2018: Diabetes & Metabolic Syndrome
Mohammed Bashir, Tarik Elhadd, Hamda Ali, Khaled Baagar, Ibrahim A Abdel Hakam, Dabia H S Al-Mohanadi, Emad Naem, Amina Al Abdulla, Kawsar Mohammed, Abdul-Badie Abou-Samra
BACKGROUND: This study aims to examine the incidence of hypoglycaemia, based on activity, during Ramadan in patients with type 2 diabetes mellitus who were on were on three or more anti-diabetic medications. METHODS: Type 2 diabetes patients who fasted during Ramadan and were on three or more anti-diabetic medications were studied for two weeks using flash glucose monitoring. The patients were asked to document all episodes of hypoglycaemia and were classified as active or sedentary according to their daytime activity...
June 7, 2018: Diabetes & Metabolic Syndrome
Heitham Awadalla, Sufian K Noor, Wadie M Elmadhoun, Sarra O Bushara, Ahmed O Almobarak, Amel Abdalrhim Sulaiman, Mohamed H Ahmed
BACKGROUND: Diabetes mellitus (DM) is a major health problem in Sudan and is a leading cause of morbidity and mortality. Dyslipidemia is a major complication of diabetes and an important risk factor for cardiovascular disease (CVD). The objective of this study was to determine the prevalence of dyslipidemia and its co-relation with the glycemic control in individuals with diabetes in River Nile State, Sudan. METHODS: Individuals with diabetes attended, Naserudin Karamalla Diabetic (NKDM) Centre, in Atbara teaching hospital during study period, who volunteered to participate were included...
June 6, 2018: Diabetes & Metabolic Syndrome
V Tsimihodimos, T D Filippatos, M S Elisaf
AIMS: Numerous clinical trials have shown that sodium glucose cotransporter 2 (SGLT2) inhibitors exert a favorable effect on the indices of renal function (albuminuria, glomerular filtration rate decline over time) and the incidence of hard renal endpoints such as renal death or time to initiation of renal replacement therapy. MATERIALS AND METHODS: In this review, we describe in detail the evidence regarding the nephroprotective mechanisms of SGLT2 inhibitors and describe the risk factors that may predispose to the development of acute kidney injury in patients receiving these drugs...
June 6, 2018: Diabetes & Metabolic Syndrome
Kijung Yoon, Seungho Ryu, Jieun Lee, Jung-Duck Park
AIMS: To determine whether hs-CRP level and interval change of hs-CRP could predict the development of metabolic abnormalities in healthy subjects in a longitudinal study. METHODS: A cohort of 3748 male who had normal hs-CRP level without evidence of any component of metabolic syndrome were studied. At each visit, hs-CRP level and metabolic abnormalities were measured. Interval change of hs-CRP for each subject was calculated. COX proportional hazard model and logistic regression analysis were used...
June 6, 2018: Diabetes & Metabolic Syndrome
Fariba Ebtekar, Sahar Dalvand, Reza Ghanei Gheshlagh
Metabolic syndrome is a set of cardiovascular risk factors that increase the risk of cardiovascular disease, diabetes and mortality. Women are at risk of developing metabolic syndrome as they enter the postmenopausal period. The present systematic review and meta-analysis was conducted to estimate the prevalence of metabolic syndrome in Iranian postmenopausal women. In this systematic review and meta-analysis, 16 national articles published in Persian and English were gathered without time limit. National databases such as SIDs, IranMedex and MagIran, and international databases such as Web of Science, Google Scholar, PubMed and Scopus were used to search the relevant studies...
June 6, 2018: Diabetes & Metabolic Syndrome
Mohammed Hadi Al-Osami, Ekhlas Khalid Hameed
BACKGROUND: Diabetes Mellitus (DM) is a major health burden worldwide. Patients with type 2 DM has various complications, including impaired bone health. Adiponectin is novel adipocytokine that could influence bone metabolism. OBJECTIVE: We investigated the relationships between serum adiponectin versus lumbar bone mineral density (BMD) in type 2 diabetic osteoporotic postmenopausal women. SUBJECTS AND METHODS: This study is a case control study included 90 postmenopausal women; divided as (group A) composed of 30 type 2 diabetic osteoporotic postmenapausal,(group B) composed of 30 non diabetic osteoporotic postmenopausal and 30 apparently healthy non osteoporotic postmenopausal women as a control group...
May 26, 2018: Diabetes & Metabolic Syndrome
Safa Abdelgadir Mohamed Elhassan, Mayuren Candasamy, Elaine Wan Ling Chan, Subrat Kumar Bhattamisra
BACKGROUND: Autophagy is a process devoted to degrade and recycle cellular components inside mammalian cells through lysosomal system. It plays a main function in the pathophysiology of several diseases. In type 2 diabetes, works demonstrated the dual functions of autophagy in diabetes biology. Studies had approved the role of autophagy in promoting different routes for movement of integral membrane proteins to the plasma membrane. But its role in regulation of GLUT4 trafficking has not been widely observed...
May 24, 2018: Diabetes & Metabolic Syndrome
Md Badrul Alam Miah, Mohammad Abu Yousuf
Millions of people in Bangladesh and the world have a metabolic disease named diabetes. It is also responsible for occurring different kinds of diseases such as heart attack, kidney disease, blindness and renal failure. Diabetes is a deadly, disabling disease whose risk is increasing at an alarming rate day by day perspective to Bangladesh. The detection process of diabetes is a tedious and multilayered task from some important risk factors. Like other diseases, Type2 diabetes also depends on some factors that are known as risk factors of Type2 diabetes...
May 23, 2018: Diabetes & Metabolic Syndrome
Seyed Alireza Ebadi, Parichehr Darvish, Ali Jamshidi Fard, Behnam Safarpour Lima, Omid Gharoei Ahangar
AIMS: Hypoglycemia can be considered the most common complication of Diabetes Mellitus treatment. So far, controversial studies have been carried out to examine the impacts of hypoglycemia on the cognitive function. METHODS: This study was conducted as case-control. The case group was 35 patients with Diabetes Mellitus Types I or II hospitalized in Imam Hussein Hospital, Tehran, Iran, who have experienced hypoglycemic attacks (glucose level below 70 mg/dl). The control group consisted of diabetic patients hospitalized in hospital, but they had no history of hypoglycemia...
May 22, 2018: Diabetes & Metabolic Syndrome
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