Synthesis of an Activatable Tetra-Substituted Nickel Phthalocyanines-4(3H)-quinazolinone Conjugate and Its Antibacterial Activity.

The aim of this study was to synthesize a series of nickel(II)phthalocyanines (NiPcs) bearing four 4(3H)-quinazolinone ring system units, (qz)4 NiPcs 4a-d . The electronic factors in the 4(3H)-quinazolinone moiety that attached to the NiPc skeleton had a magnificent effect on the antibacterial activity of the newly synthesized (qz)4 NiPcs 4a-d against Escherichia coli . The minimum MICs and MBCs value were recorded for compounds 4a , 4b , 4c , and 4d , respectively. The results indicated that the studied (qz)4 NiPcs 4a-d units possessed a broad spectrum of activity against Escherichia coli . Their antibacterial activities were found in the order of 4d  >  4c  >  4b  >  4a against Escherichia coli , and the strongest antibacterial activity was achieved with compound 4d .