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Advances in Pharmacological Sciences

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https://www.readbyqxmd.com/read/29887885/supplementation-with-alpha-tocopherol-and-ascorbic-acid-to-nonalcoholic-fatty-liver-disease-s-statin-therapy-in-men
#1
Nikola Hadzi-Petrushev, Katerina Dimovska, Nikola Jankulovski, Dine Mitrov, Mitko Mladenov
Oxidative stress and inflammation contribute to the pathogenesis and progression of nonalcoholic fatty liver disease (NAFLD), and the control of lipid status by statins may help to stop the progression of NAFLD. We hypothesized that the addition of antioxidant vitamins C and E to atorvastatin therapy is associated with improved serum enzyme antioxidant status. NAFLD-related serum parameters and the activity of antioxidant enzymes, before and after 3 months of treatment, were determined in patients receiving atorvastatin alone or atorvastatin plus antioxidants...
2018: Advances in Pharmacological Sciences
https://www.readbyqxmd.com/read/29853868/astragalin-a-bioactive-phytochemical-with-potential-therapeutic-activities
#2
REVIEW
Ammara Riaz, Azhar Rasul, Ghulam Hussain, Muhammad Kashif Zahoor, Farhat Jabeen, Zinayyera Subhani, Tahira Younis, Muhammad Ali, Iqra Sarfraz, Zeliha Selamoglu
Natural products, an infinite treasure of bioactive chemical entities, persist as an inexhaustible resource for discovery of drugs. This review article intends to emphasize on one of the naturally occurring flavonoids, astragalin (kaempferol 3-glucoside), which is a bioactive constituent of various traditional medicinal plants such as Cuscuta chinensis . This multifaceted compound is well known for its diversified pharmacological applications such as anti-inflammatory, antioxidant, neuroprotective, cardioprotective, antiobesity, antiosteoporotic, anticancer, antiulcer, and antidiabetic properties...
2018: Advances in Pharmacological Sciences
https://www.readbyqxmd.com/read/29853867/antibacterial-activity-of-two-flavans-from-the-stem-bark-of-embelia-schimperi
#3
Babe Guyasa, Yadessa Melaku, Milkyas Endale
Embelia schemperi Vatke is one of the medicinal plants used traditionally for treatment of intestinal tape worm, dysmenorrheal, bacterial, and fungal infections. Phytochemical screening test of the dichloromethane/methanol (1 : 1) and methanol extracts revealed the presence of phenols, alkaloids, tannins, and flavonoids whereas terpenoids, glycoside, and phytosterols were absent. Silica gel column chromatographic separation of the methanol extract afforded 3,5,7,3',4'-pentahydroxyflavan, named epicatechin ( 1 ), along with a close flavan derivative ( 2 )...
2018: Advances in Pharmacological Sciences
https://www.readbyqxmd.com/read/29849604/efficacy-of-aloe-vera-ananas-comosus-and-sansevieria-masoniana-cream-on-the-skin-wound-infected-with-mrsa
#4
Yos Adi Prakoso, Chylen Setiyo Rini, Roeswandono Wirjaatmadja
The tropical area has a lot of herbal medicines such as Aloe vera (AV), Ananas comosus (AC), and Sansevieria masoniana (SM). All the three have a unique potential effect as an antibacterial and wound-healing promoter. The aim of this study is to explore the role of AV, AC, and SM on the skin wound infected with methicillin-resistant Staphylococcus aureus (MRSA). Forty-five adult female Sprague Dawley rats weighing 250-300 grams were divided into 5 groups. All the groups were exposed to two round full-thickness punch biopsy and infected with MRSA...
2018: Advances in Pharmacological Sciences
https://www.readbyqxmd.com/read/29808085/synthesis-and-pharmacological-valorization-of-derivatives-of-4-phenyl-1-5-benzodiazepin-2-one
#5
Terence Nguema Ongone, Redouane Achour, Mostafa El Ghoul, Latifa El Ouasif, Khalid Taghzouti, Meryem El Jemli, Yahia Cherrah, Katim Alaoui, Amina Zellou
The objective of our work is to make a pharmacological study of molecules derived from 4-phenyl-1,5-benzodiazepin-2-one carrying long chains so that they have a structure similar to surfactants, with the benzodiazepine as a hydrophilic head and a carbon chain as a hydrophobic tail. First, we studied the acute toxicity of the above mentioned 4-phenyl-1,5-benzodiazepin-2-one derivatives. This study was conducted according to OECD 423 guidelines in female mice and revealed that these compounds are nontoxic. We then assessed the psychotropic effects of our products on the central nervous system (CNS)...
2018: Advances in Pharmacological Sciences
https://www.readbyqxmd.com/read/29805448/studies-on-the-dual-cytotoxicity-and-antioxidant-properties-of-berberis-vulgaris-extracts-and-its-main-constituent-berberine
#6
Lamyae El Khalki, Mounir Tilaoui, Abdeslam Jaafari, Hassan Ait Mouse, Abdelmajid Zyad
The present study attempts to investigate the cytotoxic activity of ethanol and ethyl acetate extracts of the Moroccan Berberis vulgaris and its major component berberine, together with exploring their antioxidant properties. It also consists of studying the combination effect of berberine and S-nitroso-N-acetylpenicillamine (SNAP), a nitric oxide (NO) donor, against the human breast adenocarcinoma cell line (MCF-7). Using the MTT assay, we report a differential cytotoxic effect of ethanol and ethyl acetate extracts since the ethanol extract is more cytotoxic than the ethyl acetate one, with IC50  = 3...
2018: Advances in Pharmacological Sciences
https://www.readbyqxmd.com/read/29755517/antibacterial-and-antioxidant-compounds-from-the-flower-extracts-of-vernonia-amygdalina
#7
Abere Habtamu, Yadessa Melaku
Vernonia amygdalina is traditionally used in Ethiopia to treat various diseases. This prompted us to isolate bioactive compounds from the flowers of this plant. The CHCl3 extract after silica gel column chromatography has led to the isolation of two compounds identified as tricosane (1) and vernolide (2) , while the acetone extract furnished isorhamnetin (3) and luteolin (4) . The acetone extract and isorhamnetin significantly scavenged the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical by 91.6 and 94%, respectively...
2018: Advances in Pharmacological Sciences
https://www.readbyqxmd.com/read/29750083/phytochemical-and-pharmacological-review-of-cryptolepis-sanguinolenta-lindl-schlechter
#8
REVIEW
Newman Osafo, Kwesi Boadu Mensah, Oduro Kofi Yeboah
Ethnopharmacological Relevance: Cryptolepis sanguinolenta is a scrambling thin-stemmed shrub found in Africa. Traditionally in West Africa, it is employed in the treatment of malaria, diarrhea, and respiratory conditions. This review discusses the traditional importance as well as the phytochemical, ethnomedical, pharmacological, and toxicological importance of this plant. Materials and Methods: Excerpta Medica Database, Google Scholar, Springer, and PubMed Central were the electronic databases used to search for and filter primary studies on Cryptolepis sanguinolenta ...
2017: Advances in Pharmacological Sciences
https://www.readbyqxmd.com/read/28694822/chemical-composition-and-cytotoxic-and-antibacterial-activities-of-the-essential-oil-of-aloysia-citriodora-palau-grown-in-morocco
#9
Moulay Ali Oukerrou, Mounir Tilaoui, Hassan Ait Mouse, Inass Leouifoudi, Abdeslam Jaafari, Abdelmajid Zyad
The aim of this work is to investigate the in vitro cytotoxic and antibacterial effects of the essential oils of Aloysia citriodora Palau, harvested in different regions of Morocco. The chemical profile was established using gas chromatography-mass spectrometry analysis. The cytotoxic activity against P815, MCF7, and VERO cell lines as well as the normal human peripheral blood mononuclear cells (PBMCs) was evaluated using the MTT assay. Standard, ATCC, strains of bacteria ( Escherichia coli , Staphylococcus aureus , and Pseudomonas aeruginosa ) were cultivated in Muller Hinton media...
2017: Advances in Pharmacological Sciences
https://www.readbyqxmd.com/read/28203250/the-effects-of-punica-granatum-flower-extract-on-skin-injuries-induced-by-burn-in-rats
#10
Ebrahim Nasiri, Seyed Jalal Hosseinimehr, Jafar Akbari, Mohammad Azadbakht, Soheil Azizi
Background. We compared the efficacy of P. granatum (P) flower extract with that of silver sulfadiazine (SSD) for treating thermal burn injuries in rats. Methods. Ten Wistar rats in each group were topically given base cream, normal saline, cream containing 1% SSD, or creams containing 5% or 10% Punica granatum flower extract. The treatments were administered once daily until complete wound healing was observed. The wound area and healing time were assessed. In addition, percentage wound contraction and histopathological characteristics such as neovascularization and collagen formation were determined...
2017: Advances in Pharmacological Sciences
https://www.readbyqxmd.com/read/27990159/changes-in-il-2-and-il-10-during-chronic-administration-of-isoniazid-nevirapine-and-paracetamol-in-rats
#11
Zanelle Bekker, Andrew Walubo, Jan B Du Plessis
The aim of this study was to illustrate the initial subclinical drug-induced liver injury and the associated adaptive immune response by monitoring for the changes in plasma IL-2, IL-10, and some cytochrome P450 activity during chronic administration of nevirapine (NVP), isoniazid (INH), and paracetamol (PAR) in rats without clinical hepatotoxicity. Male Sprague-Dawley (SD) rats were divided into four groups (saline (S), NVP, INH, and PAR) of 25 animals each. The drugs were administered daily for 42 days at therapeutic doses (NVP 200 mg/kg, PAR 500 mg/kg, and INH 20 mg/kg) to the respective groups by oral gavage and five rats per group were sacrificed weekly...
2016: Advances in Pharmacological Sciences
https://www.readbyqxmd.com/read/27812367/the-methanolic-extract-from-murraya-koenigii-l-inhibits-glutamate-induced-pain-and-involves-atp-sensitive-k-channel-as-antinociceptive-mechanism
#12
Nushrat Sharmin Ani, Sudip Chakraborty, Md Moniruzzaman
Murraya koenigii L. is a perennial shrub, belonging to the family Rutaceae. Traditionally, the leaves of this plant are extensively used in treatment of a wide range of diseases and disorders including pain and inflammation. Although researchers have revealed the antinociceptive effects of this plant's leaves during past few years, the mechanisms underlying these effects are still unknown. Therefore, the present study evaluated some antinociceptive mechanisms of the methanolic extract of M. koenigii (MEMK) leaves along with its antinociceptive potential using several animal models...
2016: Advances in Pharmacological Sciences
https://www.readbyqxmd.com/read/27635131/thrombus-degradation-by-fibrinolytic-enzyme-of-stenotrophomonas-sp-originated-from-indonesian-soybean-based-fermented-food-on-wistar-rats
#13
Florensia Nailufar, Raymond R Tjandrawinata, Maggy T Suhartono
Objective. To evaluate thrombus degrading effect of a fibrinolytic enzyme from food origin Stenotrophomonas sp. of Indonesia. Methods. Prior to animal study, the enzyme safety was tested using cell culture. The effect on expression of tissue plasminogen activator was also analysed in the cell culture. For in vivo studies, 25 Wistar rats were used: normal control, negative control, treatment groups with crude and semipurified enzyme given orally at 25 mg/kg, and positive control group which received Lumbrokinase at 25 mg/kg...
2016: Advances in Pharmacological Sciences
https://www.readbyqxmd.com/read/27478435/pharmacological-evaluation-of-naproxen-metal-complexes-on-antinociceptive-anxiolytic-cns-depressant-and-hypoglycemic-properties
#14
Md Sharif Hasan, Narhari Das, Zobaer Al Mahmud, S M Abdur Rahman
Purpose. The present study was designed to investigate the antinociceptive, anxiolytic, CNS depressant, and hypoglycemic effects of the naproxen metal complexes. Methods. The antinociceptive activity was evaluated by acetic acid-induced writhing method and radiant heat tail-flick method while anxiolytic activity was evaluated by elevated plus maze model. The CNS depressant activity of naproxen metal complexes was assessed using phenobarbitone-induced sleeping time test and the hypoglycemic test was performed using oral glucose tolerance test...
2016: Advances in Pharmacological Sciences
https://www.readbyqxmd.com/read/27403159/mdma-impairs-response-to-water-intake-in-healthy-volunteers
#15
Matthew J Baggott, Kathleen J Garrison, Jeremy R Coyle, Gantt P Galloway, Allan J Barnes, Marilyn A Huestis, John E Mendelson
Hyponatremia is a serious complication of 3,4-methylenedioxymethamphetamine (MDMA) use. We investigated potential mechanisms in two double-blind, placebo-controlled studies. In Study 1, healthy drug-experienced volunteers received MDMA or placebo alone and in combination with the alpha-1 adrenergic inverse agonist prazosin, used as a positive control to release antidiuretic hormone (ADH). In Study 2, volunteers received MDMA or placebo followed by standardized water intake. MDMA lowered serum sodium but did not increase ADH or copeptin, although the control prazosin did increase ADH...
2016: Advances in Pharmacological Sciences
https://www.readbyqxmd.com/read/27298620/a-review-on-medicinal-properties-of-orientin
#16
REVIEW
Kit Ying Lam, Anna Pick Kiong Ling, Rhun Yian Koh, Ying Pei Wong, Yee How Say
Medicinal plants continue to play an important role in modern medications and healthcare as consumers generally believe that most of them cause fewer or milder adverse effects than the conventional modern medicines. In order to use the plants as a source of medicinal agents, the bioactive compounds are usually extracted from plants. Therefore, the extraction of bioactive compounds from medicinal plants is a crucial step in producing plant-derived drugs. One of the bioactive compounds isolable from medicinal plants, orientin, is often used in various bioactivity studies due to its extensive beneficial properties...
2016: Advances in Pharmacological Sciences
https://www.readbyqxmd.com/read/27293428/radical-scavenging-activity-and-ferric-reducing-ability-of-juniperus-thurifera-l-j-oxycedrus-l-j-phoenicea-l-and-tetraclinis-articulata-l
#17
Meryem El Jemli, Rabie Kamal, Ilias Marmouzi, Asmae Zerrouki, Yahia Cherrah, Katim Alaoui
Objective. The aim of this work is to study and compare the antioxidant properties and phenolic contents of aqueous leaf extracts of Juniperus thurifera, Juniperus oxycedrus, Juniperus Phoenicea, and Tetraclinis articulata from Morocco. Methods. Antioxidant activities of the extracts were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical-scavenging ability, Trolox equivalent antioxidant capacity (TEAC), and ferric reducing antioxidant power (FRAP) assays. Also the total phenolic and flavonoids contents of the extracts were determined spectrophotometrically...
2016: Advances in Pharmacological Sciences
https://www.readbyqxmd.com/read/27247570/review-of-anti-inflammatory-herbal-medicines
#18
REVIEW
Mona Ghasemian, Sina Owlia, Mohammad Bagher Owlia
Medicinal plants and their secondary metabolites are progressively used in the treatment of diseases as a complementary medicine. Inflammation is a pathologic condition that includes a wide range of diseases such as rheumatic and immune-mediated conditions, diabetes, cardiovascular accident, and etcetera. We introduce some herbs which their anti-inflammatory effects have been evaluated in clinical and experimental studies. Curcuma longa, Zingiber officinale, Rosmarinus officinalis, Borago officinalis, evening primrose, and Devil's claw are some of the introduced medicinal herbs in this review...
2016: Advances in Pharmacological Sciences
https://www.readbyqxmd.com/read/27099614/cytotoxicity-and-antiproliferative-activity-assay-of-clove-mistletoe-dendrophthoe-pentandra-l-miq-leaves-extracts
#19
Vida Elsyana, Maria Bintang, Bambang Pontjo Priosoeryanto
Clove mistletoe (Dendrophthoe pentandra (L.) Miq.) is a semiparasitic plant that belongs to Loranthaceae family. Clove mistletoe was traditionally used for cancer treatment in Indonesia. In the present study, we examined cytotoxicity of clove mistletoe leaves extracts against brine shrimps and conducted their antiproliferative activity on K562 (human chronic myelogenous leukemia) and MCM-B2 (canine benign mixed mammary) cancer cell lines in vitro. The tested samples were water extract, ethanol extract, ethanol fraction, ethyl acetate fraction, and n-hexane fraction...
2016: Advances in Pharmacological Sciences
https://www.readbyqxmd.com/read/27087806/the-influence-of-palatable-diets-in-reward-system-activation-a-mini-review
#20
REVIEW
Isabel Cristina de Macedo, Joice Soares de Freitas, Iraci Lucena da Silva Torres
The changes in eating patterns that have occurred in recent decades are an important cause of obesity. Food intake and energy expenditure are controlled by a complex neural system involving the hypothalamic centers and peripheral satiety system (gastrointestinal and pancreatic hormones). Highly palatable and caloric food disrupts appetite regulation; however, palatable foods induce pleasure and reward. The cafeteria diet is such a palatable diet and has been shown consistently to increase body weight and induce hyperplasia in animal obesity models...
2016: Advances in Pharmacological Sciences
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