The morphofunctional features of platelets against the background of metabolic syndrome in patients with generalized marginal periodontitis.

According to modern ideas, disorders in the system of hemostasis in cardiovascular diseases are mainly due to an increase in the functional activity of platelets, namely their increased ability to adhere and aggregate. Aim of the research was to evaluate morphofunctional platelets of patients with marginal periodontitis. Material and methods of the study involved 129 men aged 28-50 years (mean age 42.97 ± 1.31 years) suffering from a MS with generalized periodontitis of mild and moderate degree. We also formed a control group of 90 practically healthy men (mean age 42.17 ± 1.34 years). Exclusion criteria are symptomatic AH, unstable angina, myocardial infarction or stroke in history, severe chronic heart failure, severe liver and kidney disease, diabetes, complete secondary adentia. Patients were performed the dental examination with determination of community periodontal index of treatment needs (CPITN), X-ray examination, physical examination with determination of anthropometric data, as well as clinical, the definition of MS laboratory criteria, insulin resistance indices, 24-h blood pressure monitoring. Platelet morphology was studied using scanning electron [17 clauser] microscopy (PhilipsPSEM 550 h) on samples prepared by a special method. The results of the study of platelet morphology in patients with MS and control group revealed a non-uniform pattern. The number of platelets in both groups being almost equal (249,6 ± 8,3х109/l and 256,8 ± 8,7х109/l respectively). Conclusion: The presented data provide strong evidence for changes in the morphofunctional state of peripheral blood platelets in patients with generalized marginal periodontitis of mild and moderate degree against the background of metabolic syndrome.