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A mitochondria-targeting photothermogenic nanozyme for MRI-guided mild photothermal therapy.
Chemical Communications : Chem Comm 2018 November 31
Iridium complexes were used as a mitochondria-targeting agent to modify the surface of a photothermogenic nanozyme Fe3O4 nanoparticles (Ir@Fe3O4 NPs). Upon NIR irradiation, Ir@Fe3O4 NPs increase the localized temperature to 42 °C which accelerates the catalysis of ˙OH production from H2O2 resulting in excellent mild photothermal therapy.
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