Control of Molecular Recognition via Modulation of the Nanoenvironment.

Many biological processes are driven by the interaction of a host with a guest molecule. We show such interactions can be modulated by carefully defining the local molecular environment to give a specific chemical outcome. Particularly, the selectivity of a host toward two different ions (Ca2+ and Al3+ ) is defined by it being in solution or the physisorbed state. In solution, the host displays greater selectivity toward Ca2+ . When physisorbed, the selectivity profile of the host is reversed with enhanced binding of Al3+ . This demonstrates a single host molecule can be tailored to selectively bind multiple guests by altering its nanoenvironment.