A pharmacological appraisal of neuroprotective and neurorestorative flavonoids against neurodegenerative diseases.

Alzheimer's disease (AD) and Parkinson's disease (PD) affect an increasing number of the elderly population worldwide. The existing treatments mainly improve the core symptoms of AD and PD in a temporary manner and cause alarming side effects. Naturally occurring flavonoids are well-documented for neuroprotective and neurorestorative effects against various neurodegenerative diseases. Thus, we analyzed the pharmacokinetics of eight potent natural products flavonoids for the druggability and discussed the neuroprotective and neurorestorative potential and the underlying mechanisms. This review provides valuable clues for the development of novel therapeutics against neurodegenerative diseases.