journal
MENU ▼
Read by QxMD icon Read
search

CNS & Neurological Disorders Drug Targets

journal
https://www.readbyqxmd.com/read/28606048/immunomodulatory-strategies-for-huntington-s-disease-treatment
#1
Gabriela Delevati Colpo, Natalia Pessoa Rocha, Erin Fur Stimming, Antonio Lucio Teixeira
Huntington's disease (HD) is an autosomal-dominant, progressive neurodegenerative disease characterized by selective loss of neurons in the striatum and cortex, which leads to progressive motor dysfunction, cognitive decline and behavioral symptoms. HD is caused by a trinucleotide (CAG) repeat expansion in the gene encoding for huntingtin (HTT). Despite the fact that the HD gene was identified over 20 years ago, there is no effective disease-modifying therapy for HD and only symptomatic therapies are available to date...
June 12, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28571531/c-abl-inhibition-a-novel-therapeutic-target-for-parkinson-s-disease
#2
Abdelrahman Ibrahim Abushouk, Ahmed Negida, Rasha Abdelsalam Elshenawy, Hossam Zein, Ali M Hammad, Ahmed Menshawy, Wael M Y Mohamed
Parkinson's disease (PD) is the most prevalent movement disorder in the world. The major pathological hallmarks of PD are death of dopaminergic neurons and the formation of Lewy bodies. To the moment, there is no cure for PD; current treatments are symptomatic. Investigators are searching for neuroprotective agents and disease modifying strategies to slow the progress of PD. However, due to ignorance of the main pathological sequence of PD, many drug targets failed recently to provide neuroprotective effects in human trials...
June 1, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28524001/brain-derived-neurotrophic-factor-promotes-growth-of-neurons-and-neural-stem-cells-possibly-by-triggering-the-phosphoinositide-3-kinase-akt-glycogen-synthase-kinase-3%C3%AE-%C3%AE-catenin-pathway
#3
Xing-Tong Li, Zhang Liang, Tong-Tong Wang, Jin-Wei Yang, Wei Ma, Shi-Kang Deng Deng, Xian-Bin Wang, Yun-Fei Dai, Jian-Hui Guo, Li-Yan Li
BACKGROUND: Brain-derived neurotrophic factor (BDNF) plays a crucial role in promoting survival and differentiation of neurons and neural stem cells (NSCs), but the downstream regulating mechanisms remain poorly understood. OBJECTIVE: We investigated whether BDNF exerts its effect by triggering the phosphoinositide 3-kinase (PI3K), protein kinase B, PKB (AKT), glycogen synthase kinase-3β (GSK-3β) and β-catenin signaling pathway in cultured neurons and NSCs derived from the rat embryonic spinal cord...
May 18, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28474544/involvement-of-microrna-146a-in-the-inflammatory-response-of-status-epilepticus-rats
#4
Qiong Luo, Linlin Zhu, Zhen Ren, Yiye Shao, Yangmei Xie, Yonghao Feng, Bing Li, Yinghui Chen
Status epilepticus (SE), which can cause neuronal injury, neuronal death and alteration of neuronal networks, is characterized by high mortality and morbidity. Recently, inflammation was shown to play a significant role in SE pathogenesis. We also found that microRNA-146a was highly expressed in SE rats with severe inflammation. The role of miRNA-146a in the inflammatory response of SE is not clear. Thus, in our study, we investigated the relationship between inflammation and miR-146a expression. We assessed the effects of thymoquinone, an anti-inflammatory drug, and found it had a neuroprotective effect on SE by inhibiting the inflammatory reaction...
May 5, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28462695/differential-mechanisms-underlying-antidepressant-responses-of-ketamine-and-imipramine
#5
Zhisheng Wei, Ke Zhang, Qinji Zhou, Mingfa Huang, Ting Xu, Jianyang Dong, Yu Zheng, Xiang Cai
Ketamine, a noncompetitive NMDA receptor antagonist, exhibits a rapid antidepressant effect, but the underlying mechanism remains obscure. Ketamine and imipramine, a tricyclic antidepressant, share the same targets on AMPA receptors and CREB, whereas ketamine exerts fast-actioning responses compared to traditional antidepressants' slow onset. To figure out why there is a significant discrepancy of their antidepressant efficiency is important for elucidating the mechanisms underlying ketamine's antidepressant effects as well as discovering new rapid antidepressants...
April 28, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28462694/obesity-and-metabolic-syndrome-affects-the-cholinergic-transmission-and-cognitive-functions
#6
Martinelli Ilenia, Tomassoni Daniele, Moruzzi Michele, Traini Enea, Seyed Khosrow Tayebati
Worldwide, at least 2.8 million people die each year as a result of being overweight or obese, that causes about 35.8 million (2.3%) of global Disability-Adjusted Life Year (DALYs). Obesity leads to metabolic syndrome, a pathological condition characterized by adverse metabolic effects on blood pressure, cholesterol, triglycerides and insulin resistance. Population-based investigations have suggested that obesity and metabolic syndrome may be associated with poorer cognitive performance and could be considered a possible risk factor for vascular Dementia and Alzheimer's Disease...
April 28, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28440193/neurocognitive-correlates-in-driving-under-the-influence-of-cannabis
#7
Francesco Paolo Busardò, Manuela Pellegrini, Julia Klein, Natale Mario di Luca
Delta (9)-tetrahydrocannabinol is the main psychoactive compound in cannabis and is commonly identified in blood samples from arrested drivers assumed to drive under the influence of drugs. Changing social norms towards cannabis and higher acceptability towards the drug emphasize the need for comprehensive understanding of the severe neurocognitive and psychomotor effects caused by cannabis and how these effects are correlated to driving skills and performance. In this review, PubMed, Cochrane Central, Scopus, Web of Science, Science Direct and EMBASE databases were used to identify and select publications up to January 2017 dealing with acute and chronic neurocognitive effects induced by cannabis and ability to drive...
April 23, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28440192/mitochondrial-permeability-transition-pore-as-a-suitable-target-for-neuroprotective-agents-against-alzheimer-disease
#8
Elena F Shevtsova, Daria Vinogradova, Margarita E Neganova, Marco Avila-Rodriguez, G M Ashraf, George E Barreto, Sergey O Bachurin, Gjumrakch Aliev
A considerable amount of data suggests the age-related impairments of mitochondrial functions in the development of sporadic forms of neurodegenerative pathologies. These includes a decrease in the calcium retention capacity of mitochondria, which leads to the disturbance of the functional activity of neurons, and increased sensitivity of mitochondria towards the induction of the permeability transition. This in turn provoke the neuronal death enhancing the development of neurodegenerative processes. Inhibitors of mitochondrial permeability transition, which increases calcium retention capacity of mitochondria, are considered as promising neuroprotective drugs able not only to halt the neurodegenerative cascade, but also to increase the functional activity of neurons...
April 23, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28440191/cannabis-a-neurological-remedy-or-a-drug-of-abuse-in-india
#9
Pronit Biswas, Pooja Mishra, Devasish Bose, Abhilasha Durgbanshi
Since ancient times it is well documented the use of cannabis as a medicine due to its potential therapeutic activity while subsequently its use as drug of abuse spread increasingly. The present review sought to give an insight in the history of medical and recreational use of cannabis in India. Indian use of cannabis dates back to Vedic time, mostly for the ritualistic and religious purposed, as documented in the ancient literature. It was India that introduced the medical use of cannabis to neighboring countries...
April 23, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28440194/concurrent-use-of-cannabis-and-alcohol-neuropsychiatric-effects-and-consequences
#10
Anna Romaguera, Marta Torrens, Esther Papaseit, Ana Lucia Arellano, Magi Farré
Concurrent use of cannabis and alcohol is frequent. According different studies, the prevalence is among 20-34% depending on different samples studied. In contrast with the wide evidence available about neuropsychiatric effects associated to the use of cannabis or alcohol separately, there are few studies of the neuropsychiatric effects of their combination. Our aim was to review the literature regarding this topic. We performed a search in MEDLINE and from 114 potentially eligible studies, 27 were selected...
April 19, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28412922/abnormalities-in-kynurenine-pathway-metabolism-in-treatment-resistant-depression-and-suicidality-a-systematic-review
#11
Gianluca Serafini, Giulia Adavastro, Giovanna Canepa, Laura Capobianco, Claudia Conigliaro, Federica Pittaluga, Martino Belvederi Murri, Alessandro Valchera, Domenico De Berardis, Maurizio Pompili, Daniel Lindqvist, Lena Brundin, Mario Amore
Treatment resistant depression (TRD) and suicidal behavior are among the most important public health problems and are commonly associated with significant disability and psychosocial impairment. Although there have been recent advances in identifying neurobiological correlates of these complex conditions, their pathophysiology still remains unclear. Although the recent advances concerning the neurobiological determinants underlying these complex conditions, their pathophysiology still remains unclear. Compared to non-suicidal subjects, higher mean concentrations of inflammatory mediators have been found in both the periphery and brain of individuals at risk for suicide...
April 13, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28412921/synthetic-cannabinoids-psychopharmacology-clinical-aspects-and-psy-chotic-onset
#12
Giovanni Martinotti, Rita Santacroce, Duccio Papanti, Yasmine Elgharably, Mariya Prilutskaya, Ornella Corazza
Synthetic Cannabinoids (SC) are the widest and most diffused class of Novel Psychoactive Substances. SC are chemically heterogeneous and structurally dissimilar from delta-9-tetrahydrocannabinol, being full agonists of the endocannabinoid system receptors CB1 and CB2. Desired effects include euphoria, talkativeness, feelings of joy and laughter, relaxation. With respect to cannabis, SC intake may also be associated with quicker arise of the effects, shorter duration of action, and larger levels of hangover...
April 13, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28412920/neuropsychiatric-and-general-interactions-of-natural-and-synthetic-cannabinoids-with-drugs-of-abuse-and-medicines
#13
Ana Lucia Arellano, Esther Papaseit, Anna Romaguera, Marta Torrens, Magi Farré
Cannabis is the most widely used illicit drug. The two most important natural cannabinoids are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). The THC content of cannabis has been increasing during the last years and recently appeared in the market a series of synthetic cannabinoids with potent agonist activity. Recreational users frequently combine cannabis with other drugs of abuse as alcohol, amphetamines and derivatives, nicotine and cocaine. In addition these subjects can be taking medicines for acute and chronic medical conditions...
April 13, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28412919/neurological-disorders-in-medical-use-of-cannabis-an-update
#14
Renata Solimini, Maria Concetta Rotolo, Simona Pichini, Roberta Pacifici
Medical cannabis is increasingly used as a treatment or adjunct treatment with different levels of efficacy in several neurological disorders or related symptoms (such as multiple sclerosis, autism, Parkinson and Alzheimer disease, Tourette's syndrome, Huntington's disease, neuropathic pain, epilepsy, headache), as well as in other medical conditions (e.g. nausea and vomiting, glaucoma, appetite stimulation, cancer, inflammatory conditions, asthma). Nevertheless, a number of neurological adverse effects from use of medical cannabis on the short- and on the long- term have been reported, in addition to other adverse health events...
April 13, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28412918/neurological-aspects-of-medical-use-of-cannabidiol
#15
Carmen Mannucci, Michele Navarra, Fabrizio Calapai, Elvira Ventura Spagnolo, Francesco Paolo Busardò, Roberto Da Cas, Francesca Menniti Ippolito, Gioacchino Calapai
BACKGROUND: Cannabidiol (CBD) is among the major secondary metabolites of Cannabis devoid of the delta-9-tetra-hydrocannabinol psychoactive effects. It is a resorcinol-based compound with a broad spectrum of potential therapeutic properties, including neuroprotective effects in numerous pathological conditions. CBD neuroprotection is due to its antioxidant and antiinflammatory activi-ties and the modulation of a large number of brain biological targets (receptors, channels) involved in the development and maintenance of neurodegenerative diseases...
April 13, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28412917/is-there-a-teratogenicity-risk-associated-with-cannabis-and-synthetic-cannabimimetics-spice-intake
#16
Laura Orsolini, Duccio Papanti, John Corkery, Maria Antonietta De Luca, Cristina Cadoni, Gaetano Di Chiara, Fabrizio Schifano
BACKGROUND: Substance use, including cannabis, has been documented amongst women both in the pre-conception period and during pregnancy, particularly during the 1st trimester, which is clearly the most critical period in the organogenesis. The recent emergence on the drug market of synthetic cannabimimetics/SC ('spice') may represent a new challenge for clinicians. OBJECTIVE: A literature overview on the teratogenicity profile of both cannabis and synthetic cannabimimetics was here carried out...
April 13, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28412916/cannabis-epidemiological-neurobiological-and-psychopathological-issues-an-update
#17
Maria Antonietta De Luca, Gaetano Di Chiara, Cristina Cadoni, Daniele Lecca, Laura Orsolini, Duccio Papanti, John Corkery, Fabrizio Schifano
Cannabis is the illicit drug with both the largest current levels of consumption and the highest lifetime prevalence in the world. Across different countries, the prevalence of cannabis use varies according to the individual income, with the highest use reported in North America, Australia and Europe. Despite its 'soft drug' reputation, cannabis misuse may be associated with several acute and chronic adverse effects. The present article aims at reviewing several papers on epidemiological, neurobiological and psychopathological aspects of the use of cannabis...
April 13, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28403801/iga-igm-responses-to-gram-negative-bacteria-are-not-associated-with-perinatal-depression-but-with-physio-somatic-symptoms-and-activation-of-the-tryptophan-catabolite-pathway-at-the-end-of-term-and-postnatal-anxiety
#18
Chutima Roomruangwong, Buranee Kanchanatawan, Sunee Sirivichayakul, George Anderson, André F Carvalho, Sebastien Duleu, Michel Geffard, Michael Maes
Evidence has implicated the translocation of commensal Gram-negative bacteria (Gram-B) due to leaky gut in the pathophysiology of depression and physio-somatic symptoms (e.g. fatigue, pain, irritable bowel syndrome, malaise, etc.). In addition, the leaky gut may contribute to immune-inflammatory activation and oxidative stress. This study investigated whether bacterial translocation is associated with perinatal depression and anxiety scores and with prenatal physio-somatic symptoms and immune-inflammatory biomarkers, including the tryptophan catabolite (TRYCAT) pathway...
April 7, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28403800/elevated-c-reactive-protein-levels-in-women-with-bipolar-disorder-may-be-explained-by-a-history-of-childhood-trauma-especially-sexual-abuse-body-mass-index-and-age
#19
Juliana Brum Moraes, Michael Maes, Decio Sabbatini Barbosa, Thais Zagabria Ferrari, Marcela Keikko Spagolla Uehara, André F Carvalho, Sandra Odebrecht Vargas Nunes
OBJECTIVES: To evaluate whether increased levels of high-sensitivity C- reactive protein (hs-CRP) observed in individuals with bipolar disorder (BD) compared to healthy controls (HCs) could be influenced by a previous exposure to early life stress (ELS) independently from other explanatory or background variables, including age, body mass index (BMI), and the presence of co-occurring mental disorders. METHODS: In this case-control study we included 142 healthy controls and 92 bipolar I and II patients...
April 7, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28393713/immune-system-modulators-with-antidepressant-effects-evidence-from-animal-models
#20
Helena M Abelaira, Amanda L Maciel, João Quevedo, Gislaine Réus
BACKGROUND: Major depressive disorder (MDD) is associated with high mortality and morbidity rates, and currently, approximately 340 million people worldwide suffer from depression at some point in life. In view of the growing socio-economic and clinical impact, several studies have focused on the etiopathology of MDD, suggesting that not only the monoaminergic system but also other brain mechanisms may be involved in the pathophysiology of MDD. Recent studies have shown a link between inflammation and MDD and have also demonstrated that antidepressants and anti-inflammatory drugs can act to reduce inflammation, thereby improving depressive symptoms...
April 4, 2017: CNS & Neurological Disorders Drug Targets
journal
journal
41296
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"