Read by QxMD icon Read

CNS & Neurological Disorders Drug Targets

Daniela V Bavaresco, Tamy Colonetti, Antônio Jose Grande, Francesc Colom, Samira S Valvassori, João Quevedo, Maria Inês da Rosa
BACKGROUND: Bipolar Disorder (BD) is a psychiatric disorder characterized by mood disturbances. The pathophysiology of BD is still poorly precise. In the last years, the study involving the role of inflammation in BD. OBJECTIVE: Performed a systematic review and meta-analysis to evaluated the potential effect of the cyclo-oxygenases (Cox)-2 inhibitor Celecoxib adjunct treatment in BD, through of randomized controlled trials (RCT). METHOD: A search of the electronic databases was proceeded, on MEDLINE, EMBASE, Scopus, Cochrane Central Register of Controlled Trials (CENTRAL), Biomed Central, Web of Science, IBECS, LILACS, PsycINFO, Congress Abstracts, and Grey literature (Google Scholar and the British Library) for studies published from January 1990 to February 2018...
November 5, 2018: CNS & Neurological Disorders Drug Targets
Andressa Leticia Miri, Andressa Panegalli Hosni, Jossinelma Camargo Gomes, Rubiana Mara Mainardes, Najeh Maissar Khalil, Rossana Gabriela Del Jesus Vásquez Marcano, Mário César da Silva Pereira, Ivo Ilvan Kerppers
BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disease characterized by the progressive and incapacitating decay of cognitive, neuropsychiatric, and behavioral manifestations. L-tryptophan is the precursor amino acid of serotonin, which is a neurotransmitter responsible for mood balance and the sense of well-being and can be administered in the form of nanoparticles. OBJECTIVE: This study analyzed the effectiveness of L-tryptophan nanoparticles and L-tryptophan on behavioral physiological alterations resulting from AD in animal models...
November 4, 2018: CNS & Neurological Disorders Drug Targets
Antonio Ibarra, Erika Mendieta-Arbesú, Paola Suarez-Meade, Elisa García-Vences, Susana Martiñón, Roxana Rodriguez-Barrera, Joel Lomelí, Adrian Flores-Romero, Raúl Silva-García, Vinnitsa Buzoianu-Anguiano, Cesar V Borlongan, Tamara D Frydman
BACKROUND- Chronic spinal cord (SC) injury is a hostile phase for regeneration known as a period of low activity with a progressive decline in neurological function. Several strategies have been investigated in this regard with no satisfactory results. OBJECTIVE- In this proof-of-concept study, we combine scar removal plus implantation of fibrin glue impregnated with mesenchymal stem cells, and immunization with neural derived peptides was included as well. METHOD- We performed three experiments, in which Sprague Dawley rats were subjected to a complete SC transection and, sixty days after the injury, the animals were randomly allocated into two groups for therapeutic intervention (TI): control and combination treatment (Comb-Tx)...
November 4, 2018: CNS & Neurological Disorders Drug Targets
Jian-Kai Yang, Hong-Jiang Liu, Yuanyu Wang, Chen Li, Ji-Peng Yang, Liang Yang, Xue-Jiao Qi, Yin-Long Zhao, Xue-Fang Shi, Jing-Chen Li, Guo-Zhu Sun, Bao-Hua Jiao
BACKGROUND/OBJECTIVE: Exosomes communicate inter-cellularly and miRNAs play critical roles in this scenario. MiR-214-5p was implicated in multiple tumors with diverse functions uncovered. However, whether miR-214-5p is mechanistically involved in glioblastoma, especially via exosomal pathway, is still elusive. Here we sought to comprehensively address the critical role of exosomal miR-214-5p in glioblastoma (GBM) microenvironment. METHODS: The relative expression of miR-214-5p was determined by real-time PCR...
November 4, 2018: CNS & Neurological Disorders Drug Targets
Benito de Celis-Alonso, Silvia S Hidalgo-Tobon, Eduardo Barragán-Pérez, Eduardo Castro-Sierra, Pilar Dies-Suarez, Julio Garcia, Eduardo Moreno Barbosa, Oscar Arias-Carrión
BACKGROUND: Impulsivity is a complex multi-dimensional combination of behaviors, which include ineffective impulse control, premature decision-making and inability to delay gratification. OBJECTIVE: The aim of this work was to explore how food odor perception and its emotional value, is affected in impulsive children. METHODS: Here we compared two cohorts of impulsive and control children, with ages between 10 and 16 years. Both groups underwent a functional magnetic resonance imaging experiment, in which food-related odor-cues were presented to all of them...
November 4, 2018: CNS & Neurological Disorders Drug Targets
Jia Zhao, Mengxia Zhu, Mukesh Kumar, Fung Yin Ngo, Yinghui Li, Lixing Lao, Jianhui Rong
Alzheimer's disease (AD) and Parkinson's disease (PD) affect an increasing number of the elderly population worldwide. The existing treatments mainly improve the core symptoms of AD and PD in a temporary manner and cause alarming side effects. Naturally occurring flavonoids are well-documented for neuroprotective and neurorestorative effects against various neurodegenerative diseases. Thus, we analyzed the pharmacokinetics of eight potent natural products flavonoids for the druggability and discussed the neuroprotective and neurorestorative potential and the underlying mechanisms...
November 4, 2018: CNS & Neurological Disorders Drug Targets
María Jesús Ramírez-Expósito, José Manuel Martínez-Martos
BACKGROUND: It has been described that doxazosin, an antihypertensive drug, also promotes glioblastoma cells death by inhibiting cell proliferation, arresting cell cycle and inducing apoptosis. Doxazosin has also demonstrated several modulator effects on renin-angiotensin system (RAS)-regulating aminopeptidase activities, which are highly involved in tumor growth in experimental glioma. Therefore, it remains to elucidate if the anti-tumoral effects of doxazosin could be also mediated by the proteolytic regulatory components of the RAS...
October 29, 2018: CNS & Neurological Disorders Drug Targets
Shuzhang Zhang, Yudan Zhu, Zhiping Zhang, Jie Tao, Yonghua Ji
The voltage-gated sodium channel, which consist of one α subunit forming the central pore and two auxiliary β subunits are responsible for the generation and propagation of action potentials in excitable cells, especially neurons. Genetic alterations in VGSCs genes, including β subunits, are always considered to be associated with epileptogenesis as well as seizures. This review aims to summarize the correlation between VGSC mutations and epilepsy. Understanding on the pathophysiological and pharmacological properties of VGSC gene defects, not only contribute to the study the disease mechanism and genetic modifiers, but also provide the theoretical basis for the precision and individualized medicine for epilepsy...
October 26, 2018: CNS & Neurological Disorders Drug Targets
Yian Huang, Yan Wang, Renjie Yan, Sheng Wang, Nan Liu, Ben Chen, Jia Chen, Li Liu
Traditional Chinese medicines (TCMs), particularly the Chinese herbal medicines, are valuable sources of medicines and have been used for centuries. The term "TCMs" both represents to the single drug agent like Salvia miltiorrhiza, Ligusticum chuanxiong and Angelica sinensis, and those herbal formulas like Jingshu Keli, Wenxin Keli and Danzhen powder. In recent years, the researches of TCMs developed rapidly to understand the scientific basis of these herbs. In this review, we collect the studies of TCM and their containing bioactive compounds, and attempt to provide an overview for their regulatory effects on different ion channels including Ca2+, K+, Na+, Cl- channels and TRP, P2X receptors...
October 26, 2018: CNS & Neurological Disorders Drug Targets
Fengjin Hao, Yueqin Feng, Yifu Guan
OBJECTIVE: Botulinum toxin has many applications in the treatment of central diseases, as biological macromolecules, it is difficult to pass through the blood-brain barrier which greatly limits their application. In this paper, we verified whether the botulinum toxin heavy chain HCS has a specific neural guidance function. METHODS: We have constructed a fusion protein with botulinum toxin heavy chain and a membrane penetrating peptide TAT (TAT-EGFP-HCS). Recombinant plasmid of botulinum toxin light chain (LC) and TAT also were constructed...
October 11, 2018: CNS & Neurological Disorders Drug Targets
Sorabh Sharma, Rajeev Taliyan, K C Sarathlal
Imbalance in histone acetylation levels and consequently the dysfunction in transcription are associated with a wide variety of neurodegenerative diseases. Histone proteins acetylation and deacetylation is carried out by two opposite acting enzymes, histone acetyl-transferases and histone deacetylases (HDACs), respectively. In-vitro and in-vivo animal models of neurodegenerative diseases and post mortem brains of patients have been reported overexpressed level of HDACs. In recent past numerous studies have indicated that HDAC inhibitors (HDACIs) might be a promising class of therapeutic agents for treating these devastating diseases...
October 4, 2018: CNS & Neurological Disorders Drug Targets
Laura Iulia Barcutean, Andreea Romaniuc, Smaranda Maier, Zoltan Bajko, Anca Motataianu, Adina Hutanu, Iunius Simu, Sebastian Andone, Rodica Balasa
Introduction We evaluated the peripheral immune panel of multiple sclerosis (MS) patients treated for more than 10 years with interferon-beta1b (IFNβ-1b) and aimed to identify possible biomarkers of treatment response. Material and Methods Serum samples from 70 MS patients treated with IFNβ-1b more than a decade were analysed for 15 cytokines, that were correlated with the disability score, annual relapse ratio (ARR): the total number of relapses-ARR_0, relapses on treatment-ARR_1 and demographic data. Two groups were defined based on the levels of disability, calculated using the Expanded Disability Status Scale (EDSS): G1 - recurrent-remissive and G2 - secondary-progressive...
September 16, 2018: CNS & Neurological Disorders Drug Targets
Arturo Solís Herrera, Ghulam Md Ashraf, Maria Del Carmen Arias Esparza, Vadim V Tarasov, Vladimir N. Chubarev, Marco F. Avila-Rodriguez, Alfiya Makhmutovа, Magdah Ganash, Osama F Mosa, Abdul Hafeez, Sergey O Bachurin, Gjumrakch Aliev
Regulation of composition, volume and turnover of fluids surrounding the brain and damp cells is vital. These fluids transport all substances required for cells and remove the unwanted materials. This regulation tends to act as barriers to prevent free exchange of materials between the brain and blood. There are specific mechanisms concerned with fluid secretion of the controlled composition of the brain, and others responsible for reabsorption eventually to blood and the extracellular fluid whatever their compositions...
September 3, 2018: CNS & Neurological Disorders Drug Targets
Xiaolin Deng, Yangmei Xie, Yinghui Chen
Epilepsy is a common and serious chronic neurological disorder that is mainly treated with antiepileptic drugs (AEDs). Although current AEDs used in clinical practice have developed into the third generation, approximately one-third of the patients are drug-resistant. More efficacious treatments for medication drug-resistant epilepsy (DRE) are therefore needed. Better understanding of the mechanism underlying DRE is likely to facilitate to develop a more effective therapy. Neuroinflammation has been proposed as a possible causative factor in the pathogenesis of epilepsy...
August 28, 2018: CNS & Neurological Disorders Drug Targets
Marianna Mazza, Giuseppe Marano, Gianandrea Traversi, Valentina Carocci, Benedetta Romano, Luigi Janiri
BACKGROUND: Cariprazine is a piprazine derivative approved by the FDA in 2015 for the treatment of schizophrenia and bipolar manic or mixed episodes in adults. High affinity for D3 dopamine receptors and observed actions on 5HT1A, 5HT2A and alpha 1B receptors differentiate it pharmacologically from other antipsychotics. METHOD: This review is a comprehensive and thorough summary of the most important findings on cariprazine use in bipolar mania and depression. Pharmacokinetics, pharmacogenetics, tolerability and safety adverse effects are discussed in this paper...
August 28, 2018: CNS & Neurological Disorders Drug Targets
Fatemeh Mohammadi, Navid Nezafat, Manica Negahdaripour, Fatemeh Dabbagh, Afshin Borhani Haghghi, Sedigheh Kianpour, Mehrzad Banihashemi, Younes Ghasemi
Heat shock proteins (HSPs) increases in response to many stresses in cells. Stroke is a neural shock that leads to destruction of a large number of brain cells, whereas induction and expression of HSPs can decrease the amount of damage, and in some conditions can cure damaged cells. HSP70 family is considered as the most important member of HSPs in normal and stress condition of cells. They are strongly up-regulated by stresses, and have protective roles in under stressed cells. Therefore, in this review we briefly consider the association between HSP70 and stroke...
August 26, 2018: CNS & Neurological Disorders Drug Targets
Ambreen Fatima, Smita Jyoti, Yasir Hasan Siddique
Parkinson's disease is the second most common neurodegenerative disorder affecting more than 1% of the population average 60. The majority of PD cases are sporadic and are probably caused by a combination of risk factors but 5-10% of the PD cases are familial. Due to the high degree of gene conservation between humans, mice and insects using animal model system is a valuable approach to further elucidate the roles of the genes in PD. The present review highlights the models use to study PD symptoms with special emphasis on Drosophila...
August 20, 2018: CNS & Neurological Disorders Drug Targets
Clayton Peixoto, Antonio Jose Grande, Mariana Mallmann, Antonio Egidio Nardi, Adriana Cardoso, Andre Barciela Veras
BACKGROUND: Depression is a mental disorder that affects a large part of the world's population. DHEA is a hormone that has long been attributed to the ability to improve depressive symptoms. However, few studies were conducted with depression individuals not resulting from other medical conditions. OBJECTIVE: To investigate whether DHEA is more effective than placebo in the treatment of depressive symptoms in subjects with depression not resulting from other psychiatric or medical comorbidities...
August 17, 2018: CNS & Neurological Disorders Drug Targets
Mona Askar, Abdelaziz M Hussein, Soheir Al-Basiony, Refka Meseha, Emile Metias, Mohamed Salama, Ashraf Antar, Aya El Sayed
In this study we aimed to investigate and to compare the effects of ferulic acid (FR), muscle exercise (Ex) and combination of them on rotenone (ROT)-induced Parkinson disease (PD) in mice as well as their underlying mechanisms. Thirty five male C57BL/6 mice were allocated into 5 equal groups, 1) Normal control (CTL) group, 2) ROT group (rats received ROT 3 mg/Kg i.p. for 70 days), 3) FR group (rats received ROT + FR at 20 mg/kg/day), 4) Ex group (rats received ROT + swimming Ex) and 5) FR+Ex group (rats received ROT + FR and Ex)...
August 15, 2018: CNS & Neurological Disorders Drug Targets
Jiaqi Li, Yuzhi Zhou, Guanhua Du, Xuemei Qin, Li Gao
Background Aging is a complex process accompanied with the decline of the different physiological functions. Numerous differentially expressed genes (DEGs) have been found in the aging brain of senescence-accelerated mouse P8 (SAMP8), however, it was challenging to screen out the crucial ones. Objective This study aimed to explore the crucial genes and pathways in aging brain of SAMP8 mice, which would be beneficial for understanding the pathogenesis of brain aging. Method Firstly, 430 genes that are differentially expressed in SAMP8 mice versus SAMR1 mice were obtained from 9 gene expression studies, and gene-gene network was constructed...
August 15, 2018: CNS & Neurological Disorders Drug Targets
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"