journal
MENU ▼
Read by QxMD icon Read
search

CNS & Neurological Disorders Drug Targets

journal
https://www.readbyqxmd.com/read/29766828/protective-effects-of-crocetin-on-depression-like-behavior-induced-by-immobilization-in-rat
#1
Tahereh Farkhondeh, Saeed Samarghandian, Fariborz Samini, Ali Rajabpour Sanati
Crocetin, an active ingredient of saffron, has been recognized as a potent antioxidant. Plant extracts or their components may be useful in ameliorating the various diseases, including neurodegenerative disorders. This study investigated the effects of crocetin on oxidative damage induced by chronic restraint stress in the rat brain. For this reason, rats were kept in the restrainers for 1 hour every day, for 21 consecutive days. The animals were injected of crocetin (20, 40, 60 mg/kg) or vehicle daily for 21 days...
May 15, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29766827/pain-related-behavior-and-brain-activation-in-a-cynomolgus-macaque-model-of-postoperative-pain
#2
Aldric Hama, Takahiro Natsume, Shin'ya Ogawa, Yūji Awaga, Ikuo Hayashi, Akihisa Matsuda, Hiroyuki Takamatsu
BACKGROUND: Inadequate postoperative pain management could lead to persistent pain and this is, in part, due to incomplete understanding of the mechanism of postoperative pain. Currently available rodent models may have limited translatability to clinical postoperative pain. Thus, a preclinical model of postoperative pain was developed in the cynomolgus macaque, a species that is phylogenetically closer to humans than rodents. METHOD: The presence of pressure hypersensitivity was assessed with non-noxious pressure applied proximally and distally (approximately 10 cm) to an abdominal incision in macaques...
May 15, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29745345/protective-effect-of-kaempferol-on-the-transgenic-drosophila-model-of-alzheimer-s-disease
#3
Yasir Hasan Siddique, Tanveer Beg, Smita Jyoti, Falaq Naz, X Rahul, Fahad Ali, Syed Kashif Ali, Ahmed Mohamed Reyad
BACKGROUND: Alzheimer's disease (AD) is characterized by the accumulation and deposition of β-amyloid peptides leading to a progressive neuronal damage and cell loss. Besides several hypotheses for explaining the neurodegenerative mechanisms, oxidative stress has been considered to be one of them. Till date, there is no cure for AD, but the pathogenesis of the disease could be delayed by the use of natural antioxidants. In this context, we decided to study the effect of kaempferol against the transgenic Drosophila expressing human Aβ-42...
May 8, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29732997/hydroxysafflor-yellow-a-reprograms-tlr9-signalling-pathway-in-ischaemic-cortex-after-cerebral-ischaemia-and-reperfusion
#4
Zhe Gong, Jingrui Pan, Xiangpen Li, Hongxuan Wang, Lei He, Ying Peng
Hydroxysafflor yellow A (HSYA) was reported to suppress inflammation in ischaemic microglia. However, the mechanism through which HSYA inhibits inflammation caused by cerebral ischaemia and reperfusion injury remains unknown. Here, we have mimicked acute cerebral ischaemia and reperfusion injury by subjecting male Sprague-Dawley (SD) rats to transient middle cerebral artery occlusion for 90 minutes and have demonstrated that toll-like receptor 9 (TLR9) was upregulated from day 3 after reperfusion, accompanied by the persistent activation of the pro-inflammatory NF-κB pathway from 6 hours to day 7...
May 1, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29714151/the-molecular-mechanism-of-vitamin-d-action-in-attention-deficit-hyperactivity-disorder-a-review-of-current-evidences
#5
Ahmad Saedisomeolia, Mahsa Samadi, Fatemeh Gholami, Marzieh Seyedi, Mohammad Effatpanah, Rezvan Hashemi, Siamand Anvari, Mina Abdolahi, Mahmoud Djalali, Niyaz Mohammadzadeh Honarvar
Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous disorder characterized by hyperactivity, impulsivity and inattention. Children with ADHD have challenges with learning, behavior and psychosocial adjustments retaining into adulthood. The exact etiology of ADHD is unknown and the pathophysiology of this disease is complex. Multifactorial hypotheses such as catecholaminergic and serotonergic systems disorders, neurotropic factors, some biological impairment with inflammatory and oxidative stress pathways are considered for ADHD...
April 30, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29714150/cinnamon-polyphenol-extract-exerts-neuroprotective-activity-in-traumatic-brain-injury-through-modulation-of-nfr2-and-cytokine-expression
#6
Burak Yulug, Ertugrul Kilic, Serdar Altunay, Cenk Ersavas, Cemal Orhan, Arman Dalay, Nurhan Sahin, Mehmet Tuzcu, Vijaya Juturu, Kazim Sahin
INTRODUCTION: Cinnamon cinnamon polyphenol extract is a traditional spice commonly used in different areas of the world for treatment of different disease conditions which are associated with inflammation and oxidative stress. Despite many preclinical studies showing the anti-oxidative, anti-inflammatory effects of CN, the underlying mechanisms in signaling pathways via which cinnamon protects the brain after brain trauma remained largely unknown. However, there is still no preclinical study delineating the possible molecular mechanism of neuroprotective effects cinnamon polyphenol extractin TBI...
April 30, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29692268/cerebrolysin-and-aquaporin-4-inhibition-improve-pathological-and-motor-recovery-after-ischemic-stroke
#7
Bogdan Catalin, Ionica Pirici, Tudor Adrian Balseanu, Adina Stan, Valerica Tudorica, Maria Balea, Ion Mindrila, Carmen Valeria Albu, Guleed Mohamed, Daniel Pirici, Dafin Fior Muresanu
BACKGROUND: Edema represents one of the earliest negative markers of survival and consecutive neurological deficit following stroke. The mixture of cellular and vasogenic edema makes treating this condition complicated, and to date, there is no pathogenically oriented drug treatment for edema, which leaves parenteral administration of a hypertonic solution as the only non-surgical alternative. OBJECTIVE: New insights into water metabolism in the brain have opened the way for molecular targeted treatment, with aquaporin 4 channels (AQP4) taking center stage...
April 25, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29692267/oxidative-stress-in-neurodegenerative-diseases-a-review
#8
Amirhossein Sahebkar, Yunes Panahi, Habib Yaribeygi, Behjat Javadi
BACKGROUND: Neurodegeneration is a condition in which progressive loss of function and structure of neurons happen. Many lines of evidence suggest that oxidative stress have a central role in neurodegenerative diseases. OBJECTIVE: To survey molecular mechanisms underlying the involvement of oxidative stress in developing different neurodegenerative diseases. METHODS: Original and review articles were retrieved through a PubMed and Google scholar search (from 1989 to 2015) using the following key words: "oxidative stress", "nerve degeneration" and "neurodegenerative diseases"...
April 25, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29692269/clinical-observation-of-electroencephalographic-changes-and-risk-of-convulsion-occurrence-in-children-receiving-neural-precursor-cell-transplantation
#9
Suqing Qu, Weipeng Liu, Hui Yang, Zhaoyan Wang, Yinxiang Yang, Fang Liu, Aruna Sharma, Hari Sharma, Zuo Luan
PURPOSE: This study was intended to observe electroencephalographic (EEG) changes and convulsion attacks in children receiving neural precursor cell transplantation, and to explore the possibility of electrophysiological changes and risk of convulsion occurrence after cell transplantation. METHOD: Included in this study were 227 children who received neural precursor cell transplantation in our hospital between March 2008 and July 2012. No history of convulsion attacks was elicited before cell transplantation...
April 24, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29676237/ultramicronized-palmitoylethanolamide-effects-on-sleep-wake-rhythm-and-neuropathic-pain-phenotypes-in-patients-with-carpal-tunnel-syndrome-an-open-label-randomized-controlled-study
#10
Maurizio Evangelista, Vitale Cilli, Rocco De Vitis, Arturo Militerno, Francesco Fanfani
BACKGROUND: Patients with carpal tunnel syndrome often suffer from fragmentary sleep. This study was designed to assess the effectiveness of treatment with ultramicronized palmitoylethanolamide in reducing pain intensity and in improving quality of sleep in patients with neuropathic pain due to carpal tunnel syndrome. METHODS: An open, controlled study was conducted on 42 patients awaiting carpal tunnel syndrome surgery, suffering from sleep disorders and painful symptoms and randomized into two groups...
April 20, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29676236/monoamine-involvement-in-the-antidepressant-like-effect-of-%C3%AE-caryophyllene
#11
Danillo Ramos Oliveira, Dayane Moreira Silva, Iziara Ferreira Florentino, Adriane de Brito, James Oluwagbamigbe Fajemiroye, Daiany Priscilla Bueno Silva, Fabio da Rocha, Elson Alves Costa, Pablinny Galdino De Carvalho
This study was conducted to evaluate the antidepressant-like activity of sesquiterpene compound β-caryophyllene (BCP) for the possible contribution of the monoamine and hippocampal levels of brain-derived neurotrophic factor (BDNF). Male albino Swiss mice were subjected to the forced swimming test after acute treatment and to the tail suspension test after repeated treatment. Hippocampal levels of BDNF were assayed by enzyme-linked immunosorbent assay. The anti-immobility effect of BCP was reverted by pretreatment with inhibitor of catecholamines α-methyl-p-tyrosine (100 mg/kg, i...
April 20, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29676235/current-and-promising-therapies-in-autosomal-recessive-ataxias
#12
Vincent Picher-Martel, Nicolas Dupre
BACKGROUND & OBJECTIVE: Ataxia is clinically characterized by unsteady gait and imbalance. Cerebellar disorders may arise from many causes such as metabolic diseases, stroke or genetic mutations. The genetic causes are classified by mode of inheritance and include autosomal dominant, X-linked and autosomal recessive ataxias. Many years have passed since the description of Friedreich's ataxia, the most common autosomal recessive ataxia, and mutations in many other genes have now been described...
April 18, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29651972/n-3-omega-3-fatty-acids-effects-on-brain-dopamine-systems-and-potential-role-in-the-etiology-and-treatment-of-neuropsychiatric-disorders
#13
Beth Levant, Michelle Healy-Stoffel
A number of neuropsychiatric disorders, including Parkinson's disease, schizophrenia, attention deficit hyperactivity disorder, and, to some extent, depression, involve dysregulation of the brain dopamine systems. The etiology of these diseases is multifactorial, involving genetic and environmental factors. Evidence suggests that inadequate levels of n-3 (omega-3) polyunsaturated fatty acids (PUFA) in the brain may represent a risk factor for these disorders. These fatty acids, which are derived from the diet, are a major component of neuronal membranes and are of particular importance in brain development and function...
April 12, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29651971/stephen-william-hawking-8-january-1942-14-march-2018
#14
Cinzia Volonte, Stephen D Skaper
No abstract text is available yet for this article.
April 11, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29637872/growth-factors-changes-in-cerebrospinal-fluid-of-children-with-mental-retardation-before-and-after-neural-precursor-cell-transplantation
#15
Hari Shanker Sharma, Hui Yang, Yinxiang Yang, Suqing Qu, Zhaoyan Wang, Wei Lu, Fang Liu, Weipeng Liu, Qian Wang, Aruna Sharma, Zuo Luan
OBJECTIVE: To investigate growth factor changes in cerebrospinal fluid (CSF) of children with mental retardation (MR) before and after neural precursor cell transplantation (NPCT), in an attempt to provide experimental clues for the clinical treatment of MR with NPCT. METHODS: The study comprised 28 MR children who received twice NPCT in our hospital. CSF was collected at both NPCT to assess growth factors by ELISA. In addition, the content of insulin-like growth factor 1 (IGF-1) in CSF was assayed to determine possible correlations between IGF-1 changes and the short-term therapeutic effect of NPCT...
April 10, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29623859/non-invasive-cerebellar-stimulation-in-cerebellar-disorders
#16
Roberta Ferrucci, Ciara Di Nuzzo, Fabiana Ruggiero, Francesca Cortese, Ilaria Cova, Alberto Priori
Non-invasive brain stimulation (NIBS) might be a valuable therapeutic approach for neurological diseases by modifying the cortical activity in the human brain and promoting neural plasticity. Currently, researchers are exploring the use of NIBS on the cerebellum to promote functional neural changes in cerebellar disorders. In the presence of cerebellar dysfunction, several movement disorders, such as kinetic tremor, ataxia of gait, limb dysmetria and oculomotor deficits, become progressively more disabling in daily life, and no pharmacological treatments currently exist...
April 3, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29623857/the-large-conductance-calcium-and-voltage-activated-potassium-channel-bk-and-epilepsy-a-short-review
#17
Kai Zang, Yuwen Zhang, Jie Hu, Yun Wang
The large conductance calcium- and voltage-activated potassium channels (BK) are a kind of widely distributed channel proteins which exist in virtually every cell type of mammals and function to influence membrane excitability and Ca2+ signaling. BK channels can be activated by the increase of the intracellular Ca2+ concentration, a consequence of neuronal excitation, and then terminate the action potential with the outward K+ flux. Moreover, after-hyperpolarization induced by BK channels closes Cav channels and thus precludes excessive Ca2+ influx...
April 3, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29589548/characterization-of-regulatory-t-cells-in-multiple-sclerosis-patients-treated-with-interferon-beta-1a
#18
Mohsen Ebrahimi, Ali Ganji, Sarah Zahedi, Parisa Nourbakhsh, Keyvan Ghasami, Ghasem Mosayebi
BACKGROUND: Regulatory T-Cells (Treg Cells), as one of the immune system components, have been highly effective in the autoimmune diseases prevention, particularly multiple sclerosis (MS). Cytokine-based therapies such as interferon beta-1a (IFN-β1a) is a common drug in MS treatment; however, its exact mechanisms are insufficiently described. OBJECTIVE: Therefore, the goal of this study was to evaluate the in vivo impact of IFN-β1a on the Treg Cells in MS. METHODS: In this case-control study, Treg Cells were analysed by flowcytometry in IFN-β1a-treated relapsing-remitting MS (RRMS) in comparison with new cases of MS and healthy subjects...
March 27, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29546838/an-investigation-of-the-effects-of-curcumin-on-the-changes-in-the-central-nervous-system-of-rats-exposed-to-aroclor-1254-in-the-prenatal-period
#19
Mehmet Eray Alcigir, Halef Okan Dogan, Begum Yurdakok, Kubra Dogan, Sevil Vural, Fatma Meric Yilmaz, Atilla Isgoren
Aroclor 1254 is a widespread toxic compound of Polychlorinated Biphenyls (PCBs), which can create significant nervous problems. No remedies have been found to date. The aim of this study was to reveal the damage that occurs in the central nervous system of rat pups exposed to Aroclor 1254 in the prenatal period, and to show the inhibiting effect of curcumin, which is a strong anti-oxidant and neuroprotective substance. The study established 3 groups of adult female and male Wistar albino rats. The rats were mated within these groups and the offspring rats were evaluated within the group given Aroclor 1254 only (n=10) and the group given both Aroclor 1254 and curcumin (n=10) and the control group (n=10)...
March 15, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29546837/physiological-and-morphological-principles-underpinning-recruitment-of-the-cerebellar-reserve
#20
Shinji Kakei, Takahiro Ishikawa, Jongho Lee, Takeru Honda, Donna S Hoffman
BACKGROUND: In order to optimize outcomes of novel therapies for cerebellar ataxias (CAs), it is desirable to start these therapies while declined functions are restorable: i.e. while the so-called cerebellar reserve remains. OBJECTIVE: In this mini-review, we tried to define and discuss the cerebellar reserve from physiological and morphological points of view. METHOD: The cerebellar neuron circuitry is designed to generate spatiotemporally organized outputs, regardless of the region...
March 15, 2018: CNS & Neurological Disorders Drug Targets
journal
journal
41296
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"