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Seco-Tetracenomycins from the Marine-Derived Actinomycete Saccharothrix sp. 10-10.
Marine Drugs 2018 September 21
Six new tetracenomycin congeners, saccharothrixones E⁻I ( 1 ⁻ 5 ) and 13-de- O -methyltetracenomycin X ( 6 ), were isolated from the rare marine-derived actinomycete Saccharothrix sp. 10-10. Their structures were elucidated by spectroscopic analysis and time-dependent density functional theory (TDDFT)-electronic circular dichroism (ECD) calculations. Saccharothrixones G ( 3 ) and H ( 4 ) are the first examples of tetracenomycins featuring a novel ring-A-cleaved chromophore. Saccharothrixone I ( 5 ) was determined to be a seco -tetracenomycin derivative with ring-B cleavage. The new structural characteristics, highlighted by different oxidations at C-5 and cleavages in rings A and B, enrich the structural diversity of tetracenomycins and provide evidence for tetracenomycin biosynthesis. Analysis of the structure⁻activity relationship of these compounds confirmed the importance of the planarity of the naphthacenequinone chromophore and the methylation of the polar carboxy groups for tetracenomycin cytotoxicity.
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