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Identification of a potent kinase inhibitor targeting EML4-ALK fusion protein in non-small cell lung cancer.
MedChemComm 2017 October 2
ALK-fusion proteins play a fundamental role in the development of about 5% of non-small cell lung cancers. Herein, we identified the compound 5067-0952 as a potent ALK inhibitor, which inhibited cell growth, induced apoptosis, and suppressed the phosphorylation of ALK, subsequently blocking its downstream signaling pathway.
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