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Synthesis of New 1,3,5-Triazine-Based 2-Pyrazolines as Potential Anticancer Agents.
A new series of 1,3,5-triazine-containing 2-pyrazoline derivatives ( 8 ⁻ 11 ) a ⁻ g was synthesized by cyclocondensation reactions of [(4,6-bis((2-hydroxyethyl)amino)-1,3,5-triazin-2-yl)amine]chalcones 7a ⁻ g with hydrazine hydrate and derivatives. Chalcones 7a ⁻ g were obtained by Claisen-Schmidt condensation between aromatic aldehydes and triazinic derivative 5 , which was synthesized in high yield by a microwave-assisted reaction. Seventeen of the synthesized compounds were selected and tested by the US National Cancer Institute (NCI) for their anticancer activity against 58 different human tumor cell lines. Compounds 7g and 10d , e , g showed important GI50 values ranging from 0.569 to 16.6 µM and LC50 values ranging from 5.15 to >100 µM.
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