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Overcoming Depression by Inhibition of Neural Burst Firing.

Daesoo Kim, Eunji Cheong, Hee-Sup Shin
Neuron 2018 June 7
The N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine has been found to have rapid and long-lasting antidepressive effects. Two elegant studies from Hailan Hu's laboratory (Cui et al., 2018; Yang et al., 2018) showed that ketamine blocks burst firing of neurons in the lateral habenula (LHb), rapidly relieving symptoms of depression.

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