Production and Functionality of Food-derived bioactive peptides: A review.

Proteins are present in a wide range of our everyday foods and complex macromolecules made up of one or more polypeptide chains. From these common food, large amount of bioactive peptides can be produced. An array of biological health effects have been attributed to these peptides, including antioxidative, antihypertensive, antidiabetic, anticoagulant, antithrombotic, anti-inflammatory, hypocholesterolemic and immunomodulating. The chemical structure of biological active peptides were closely related with its specific biological activity. Meanwhile, the amino acid composition and sequence information of peptide molecular chain have an important influence on its physiological activity. Food-derived bioactive peptides were typically released from animal and plant proteins via enzymatic hydrolysis under in vitro or in vivo conditions using different kinds of protease. However, the production, separation and purification of bioactive peptides with desired specific functions have become a focus and challenge. In addition, it needs further studies on mechanism of action and multiple biological functionalities. In this present review, recent biotechnological advances in the production, purification and identification of bioactive peptides were focuses on. Several kinds of common bioactive peptides and their methods to evaluate were also reviewed.