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Nanoparticles Conjugated with Photocleavable Linkers for the Intracellular Delivery of Biomolecules.

Adrián Jiménez-Balsa, Sandra Pinto, Emanuel Quartin, Miguel M Lino, Vitor Francisco, Lino Ferreira
Bioconjugate Chemistry 2018 May 17
We report the synthesis and characterization of phototriggerable polymeric nanoparticles (NPs) for the intracellular delivery of small molecules and proteins to modulate cell activity. For that purpose, several photocleavable linkers have been prepared providing diverse functional groups as anchoring points for biomolecules.

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