Whitney Shatz-Binder, Caleigh M Azumaya, Brandon Leonard, Ivan Vuong, Jawahar Sudhamsu, Alexis Rohou, Peter Liu, Wendy Sandoval, Karenna Bol, Saeed Izadi, Patrick G Holder, Craig Blanchette, Remo Perozzo, Robert F Kelley, Yogeshvar Kalia
Ferritin is a multivalent, self-assembling protein scaffold found in most human cell types, in addition to being present in invertebrates, higher plants, fungi, and bacteria, that offers an attractive alternative to polymer-based drug delivery systems (DDS). In this study, the utility of the ferritin cage as a DDS was demonstrated within the context of T cell agonism for tumor killing. Members of the tumor necrosis factor receptor superfamily (TNFRSF) are attractive targets for the development of anticancer therapeutics...
April 9, 2024: Bioconjugate Chemistry