Effectiveness of four-factor prothrombin complex concentrates versus plasma on vitamin K antagonist associated plasma international normalized ratio reversal: a systematic review protocol.

Andrew McPhail, Dominick Jokel

JBI Database of Systematic Reviews and Implementation Reports 2018 March

REVIEW QUESTION: The question of this review is: what is the effectiveness of Kcentra/Beriplex/Confidex compared to plasma for international normalized ratio (INR) reduction in adult patients (18 years and over) on any vitamin K antagonist therapy?

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