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Acute lymphoblastic leukemia secondary to myeloproliferative neoplasms or after lenalidomide exposure.
Clinical Case Reports 2018 January
Philadelphia-negative (Ph- ) myeloproliferative neoplasms (MPN) do rarely transform to acute lymphoblastic leukemia (ALL). While causality is difficult to establish, a few cases of ALL arising after exposure to lenalidomide for registered indications (multiple myeloma, myelodysplastic syndrome with 5q deletion) have been described in the literature.
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