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Automated radiosynthesis of Al[ 18 F]PSMA-11 for large scale routine use.
Applied Radiation and Isotopes 2018 May
OBJECTIVES: We report a reproducible automated radiosynthesis for large scale batch production of clinical grade Al[18 F]PSMA-11.
METHODS: A SynthraFCHOL module was optimized to synthesize Al[18 F]PSMA-11 by Al[18 F]-chelation. Results Al[18 F]PSMA-11 was synthesized within 35min in a yield of 21 ± 3% (24.0 ± 6.0GBq) and a radiochemical purity > 95%. Batches were stable for 4h and conform the European Pharmacopeia guidelines.
CONCLUSIONS: The automated synthesis of Al[18 F]PSMA-11 allows for large scale production and distribution of Al[18 F]PSMA-11.
METHODS: A SynthraFCHOL module was optimized to synthesize Al[18 F]PSMA-11 by Al[18 F]-chelation. Results Al[18 F]PSMA-11 was synthesized within 35min in a yield of 21 ± 3% (24.0 ± 6.0GBq) and a radiochemical purity > 95%. Batches were stable for 4h and conform the European Pharmacopeia guidelines.
CONCLUSIONS: The automated synthesis of Al[18 F]PSMA-11 allows for large scale production and distribution of Al[18 F]PSMA-11.
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