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Dual Roles of Ctf18-RFC: Loading the Clamp and Angling for the Polymerase.
Structure 2018 January 3
Clamp loaders such as Ctf18-RFC assist DNA replication by loading the PCNA clamp onto DNA. In this issue of Structure, Grabarczyk et al. (2018) reveal that a hook-like structure formed by the unique Dcc1 and Ctf8 subunits mediates the interaction of Ctf18-RFC with the leading strand DNA polymerase ɛ.
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