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Plasmodium Peekaboo: PK4 Mediates Parasite Latency.

Edward Rea, Anthony A Holder, Rita Tewari
Cell Host & Microbe 2017 December 14
In this issue of Cell Host & Microbe, Zhang et al. (2017) show that translational repression through eIF2α phosphorylation mediated by PK4 kinase activity plays a key role in artemisinin resistance in recrudescent malaria infections. Targeting this druggable process could extend the lifespan of current frontline treatments.

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