The Relationship Between MDM2 T309G Polymorphism and Leukemia in the Chinese Population: Evidence from a Meta-Analysis.

BACKGROUND: Increasing numbers of studies have been carried out on the association of MDM2 T309G polymorphism with susceptibility to leukemia and have generated conflicting results. This meta-analysis updated and revaluated the possible associations between MDM2 T309G polymorphism and leukemia in the Chinese population.

METHODS: The PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure, and Chinese Biology Medicine were searched up to February 2017. Fixed-effect and random-effect meta-analytical techniques were conducted for the outcome measure and subgroup analyses.

RESULTS: Overall, the meta-analysis demonstrated significant associations between the MDM2 T309G polymorphism and increased risk for leukemia in the Chinese population. Subgroup analyses indicated similar results in South China. As for subgroup analysis by clinical types, data suggested increased risk for chronic myeloid leukemia (CML).

CONCLUSIONS: Our study suggested that MDM2 T309G polymorphism might be a low-penetrant risk factor for leukemia among Chinese.