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Clinical Laboratory

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https://www.readbyqxmd.com/read/28792720/performance-of-clinical-features-acute-phase-reactants-and-group-a-streptococcus-rapid-test-in-evaluation-of-the-etiologic-agents-for-tonsillopharyngitis-in-children
#1
Bahri Elmas, Mehmet Köroğlu, Hüseyin A Terzi, Ferhat G Aslan, Engin Menekşe, Mustafa Kösecik, Mustafa Altindiş
No abstract text is available yet for this article.
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28792719/evaluation-of-3-hemoglobin-a1c-point-of-care-instruments-point-of-care-testing-for-hba1c-evaluation-of-cobas-b101-b-analyst-and-afinion%C3%A2
#2
María De Toro-Crespo, Catalina Sánchez-Mora, Patricia Fernández-Riejos, José M Maesa-Márquez, Concepción González-Rodríguez
No abstract text is available yet for this article.
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28792718/mdr-1-and-cyp3a5-polymorphisms-in-pediatric-idiopathic-nephrotic-syndrome-impact-on-susceptibility-and-response-to-steroids-preliminary-results
#3
Amira Moussa, Sameh Mabrouk, Haithem Hamdouni, Maroua Ajmi, Miniar Tfifha, Asma Omezzine, Saoussen Abroug, Ali Bouslama
BACKGROUND: Oral steroid treatment is the first line of therapy for childhood nephrotic syndrome (NS). However, resistance to this treatment has been observed in some patients. Here, we investigated the association of two steroid metabolism-related genes with susceptibility to childhood NS and the steroid response. METHODS: We genotyped the single nucleotide polymorphisms (SNP) of MDR-1 [C1236T (rs1128503), G2677T/A (rs2032582), and C3435T (rs1045642)] and the CYP3A5 gene (A6986G) in 63 NS patients and 110 age and gender matched controls by PCR-RFLP...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28792717/the-relationship-between-serum-tarc-tslp-and-postn-levels-and-childhood-atopic-dermatitis
#4
Pinar Uysal, Fatih Birtekocak, Aslihan Buyukozturk Karul
BACKGROUND: The aim of the study is to evaluate the relationship between serum periostin (POSTN), thymus and activation-regulated chemokine (TARC), and thymic stromal lymphopoietin (TSLP) levels and disease severity and atopy in children with atopic dermatitis. METHODS: Sixty children with atopic dermatitis and 31 healthy controls were included in the study. The disease severity was measured by SCORAD scores. Serum POSTN, TARC, and TSLP levels were measured in all participants...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28792716/a-3-month-old-child-with-acute-gastroenteritis-with-enterovirus-d68-detected-from-stool-specimen
#5
Ngan T K Pham, Aksara Thongprachum, Tsuneyoshi Baba, Shoko Okitsu, Quang D Trinh, Shihoko Komine-Aizawa, Hiroyuki Shimizu, Satoshi Hayakawa, Hiroshi Ushijima
Enterovirus D68 (EV-D68) is known to be causative agent of mild to severe upper and lower respiratory illnesses in sporadic cases and outbreaks. We present a case report of a 3-month-old child with acute gastroenteritis who visited a pediatric clinic in Kyushu area in Japan in 2015. A stool sample collected from the patient was screened for diarrheal viruses by multiplex RT-PCR. The result showed that the sample was positive only for enterovirus, and EV-D68 clade B3 was identified by sequence analysis of the viral protein 1 gene...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28792715/mutational-screening-of-pkd1-and-pkd2-genes-in-iranian-population-diagnosed-with-autosomal-dominant-polycystic-kidney-disease
#6
Fariba Ranjzad, Ahmad Tara, Abbas Basiri, Nasser Aghdami, Reza Moghadasali
BACKGROUND: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the fourth most frequent cause of endstage renal disease (ESDR), occurring at a varying frequency of 1/400 to 1/800 persons. The disease affects all ethnic groups worldwide, and there is a need for population based studies to be carried out for better diagnostic, genetic counselling, and treatment purpose. METHODS: Eighteen unrelated probands (10 males and 8 females) with a familial history of ADPKD were selected for the study...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28792714/preparation-of-commutable-frozen-human-serum-candidate-reference-materials-for-standardization-of-sodium-measurements
#7
Rui Zhang, Shunli Zhang, Qingtao Wang
BACKGROUND: The measurement of serum sodium is important in the diagnosis of diseases. However, the accuracy and comparability of results in clinical laboratories are not ideal. The aim of this study was to prepare the candidate reference materials (RMs) to standardize serum sodium measurements. METHODS: Fresh sera without hemolysis, lipemia, and choloplania were collected and packed in the cryovials. According to ISO Guide 35, the homogeneity and stability were tested...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28792713/investigation-of-fc-receptor-like-3-fcrl-3-gene-polymorphism-rs7528684-with-susceptibility-to-allergic-asthma-in-iranian-north-western-azeri-population
#8
Lida Aslanian-Kalkhoran, Daniel Elieh-Ali-Komi, Mahnaz Sadeghi-Shabestari, Dariush Shanebandi, Zohreh Babaloo, Alireza Razavi, Saeed Sadigh-Eteghad, Tohid Kazemi
BACKGROUND: Asthma is a clinical setting in which multiple cellular and molecular mechanisms are involved. Additionally, increasing genetic studies have provided evidence that single nucleotide polymorphisms (SNPs) in asthma relevant genes confer susceptibility to the disease. Fc receptor-like (FCRL) 3, a transmembrane molecule basically involved in B-cell signaling, mediates immune-disorders including allergy. Aim of study was to investigate the possible association of rs7528684 SNP in FCRL3 gene with a predisposition to allergic asthma in Iranian North-western Azeri population...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28792712/external-quality-assessment-of-first-trimester-prenatal-biochemical-screening-in-china
#9
Shishi Zhang, Xiaoyan Zhang, Wei Wang, Falin He, Kun Zhong, Shuai Yuan, Zhiguo Wang
BACKGROUND: Free β subunit of human chorionic gonadotropin (free β-hCG) and pregnancy-associated plasma protein A (PAPP-A) are two important biomarkers in first-trimester prenatal screening. This study intended to reflect their analytical performance in clinical laboratories and main platforms of the 2015 External Quality Assessment (EQA) scheme for the first-trimester biochemical screening in China. METHODS: Ten lyophilized EQA samples, divided into two sets and analyzed in two cycles 20151 and 20152, were distributed to each participant in 2015...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28792711/differential-expression-of-micrornas-in-calcific-aortic-stenosis
#10
Hai-Xia Xu, Yan Wang, Dong-Dong Zheng, Teng Wang, Min Pan, Jia-Hai Shi, Jian-Hua Zhu, Xiao-Fei Li
BACKGROUND: Calcific aortic stenosis (CAS) is the most common heart valve disorder. To explore the underlying mechanisms, we investigated whether key microRNAs in calcified aortic valves are differentially expressed compared to those in the non-calcified valves. METHODS: Calcified aortic valves from patients with aortic stenosis and non-calcified aortic valves (control) from patients with aortic insufficiency (n = 8 per group) were obtained during cardiac valve replacement surgery...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28792710/effects-of-passive-smoking-on-glycemic-parameters-and-lipid-profiles-in-a-chinese-female-population
#11
Lijuan Gu, Jing Li, Gui Pan, Xiaojun Zhou, Jianmin Zhang, Xiaoyang Lai, Jianping Liu
BACKGROUND: The adverse effects of exposure to second-hand cigarette smoke on glucose and lipid parameters in women and the underlying mechanisms are not well understood. In this prospective community-based study, we examined the effects of passive smoking on glycemic parameters and lipid profiles in a Chinese female population. METHODS: Of 3197 healthy women enrolled (30 - 75 years), 2082 self-reported passive exposure to smoke (≥ 15 minutes/day, 3 days/week, > 1 year) and 1115 had no smoke exposure (control group)...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28792709/assessment-of-glycated-albumin-as-a-useful-indicator-for-renal-dysfunction-in-diabetic-and-nondiabetic-population
#12
Nan Duan, Sai-Nan Zhu, Hai-Xia Li, Li-Li Jiao, Hong-Yun Yang, Qi Guo
BACKGROUND: Glycated albumin (GA) reflects serum glucose of the preceding 2 - 3 weeks and plays an important role in diabetes mellitus (DM). This study aimed at investigating whether GA can assess renal dysfunction in population. METHODS: 3818 individuals attending physical examination were enrolled in this cross-sectional study and divided into five groups: healthy controls, impaired fasting glucose, DM without renal complications, DM with albuminuria, and nondiabetic chronic kidney disease patients...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28792708/correlation-of-fasting-versus-postprandial-plasma-glucose-with-hba1c-in-chinese-type-2-diabetic-patients-taking-different-hypoglycemic-agents
#13
Xiang Wang, Fang Wang, Haifeng Wang, Nan Li
BACKGROUND: Currently, it is not well understood how the contribution of basal versus postprandial plasma glucose changes in the management of type 2 diabetes mellitus (DM) with different treatment regimens. This study aimed to investigate the relationships between glycated hemoglobin (HbA1c) and fasting as well as postprandial blood glucose and to determine how these relationships changed during DM progression in Chinese diabetic patients with different treatment regimens. METHODS: Continuous glucose monitoring was conducted in 228 type 2 DM patients with stable glucose levels...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28792707/limitations-of-preoperative-pfa-200-as-a-predictor-of-postoperative-blood-loss-in-total-knee-arthroplasty-according-to-use-of-tranexamic-acid
#14
You La Jeon, Woo-In Lee, So Young Kang, Myeong Hee Kim
BACKGROUND: Recently, anti-fibrinolytic agents (tranexamic acid) have been used to reduce blood loss or and the need for transfusion. We evaluated the clinical utility of PFA-200 as a predictor of postoperative blood loss in a clinical setting, where hemostasis can be affected by variables such as existing comorbidities and medication use. METHODS: We analyzed retrospectively 243 TKA patients having PFA-200 results between March 2014 and May 2016. We collected the medication history of anti-thrombotic agents, closure time measured by PFA-200, postoperative drainage volume, and perioperative change of hemoglobin values...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28792706/lack-of-association-between-slc6a11-genetic-polymorphisms-and-drug-resistant-epilepsy-in-chinese-han-population
#15
Y Y Xie, J Qu, L Zhou, N Lv, J E Gong, Y Z Cao, L L Long, H Y Long, B Xiao
BACKGROUND: Epilepsy is one of the most common chronic neurological diseases. A recent study has implicated that the genetic variants of the SLC6A11 gene encoding GAT-3, an astrocytic GABA transporter, may influence the efficacy of antiepileptic drugs (AEDs) in the Korean population. METHODS: This study aims to investigate the possible associations between SLC6A11 gene and drug resistance in Chinese epilepsy patients. Genomic DNA from 240 drug resistant epilepsy (DRE) patients and 336 drug responsive epilepsy patients was tested for the polymorphisms using Illumina GoldenGate assay...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28792705/homocysteine-metabolism-and-hematological-parameters-in-early-stage-of-phenytoin-treated-epileptic-children
#16
Tarun K Sharma, S K Vardey, S Sitaraman
BACKGROUND: Long-term antiepileptic drug (AED) therapy has been associated with metabolic consequences that lead to an increase in risk of atherosclerosis in patients with epilepsy. Earlier published studies showed conflicting results about the levels of hematological parameters, serum homocysteine, folate, and vitamin B12, in epileptics treated with phenytoin monotherapy. Therefore, we evaluated homocysteine metabolism and hematological parameters in early stage of phenytoin treated epileptic children...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28792704/epigenetic-modification-of-microrna-205-and-its-association-with-glioblastoma-multiform
#17
Asghar Ghasemi, Soudabeh Fallah
BACKGROUND: Deregulated expressions of tumor-suppressive microRNAs (miRNAs) by epigenetic aberrations has a critical role in tumorigenesis. The aim of the present study was to investigate the epigenetic aberrations of miR205 and to understand how this modification may contribute to molecular events in glioblastoma multiform (GBM). METHODS: Quantitative RT-PCR and bisulfite genomic sequencing techniques were used to investigate gene expression and methylation levels of miR-205 in GBM tissues (n = 23), their matched adjacent normal tissues (n = 23) and glioblastoma U87MG cell line...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28792703/study-of-myoc-gene-mutation-in-poag-patients-in-zahedan-iran
#18
Mehrnaz Narooie-Nejad, Ava Rasouli, Mahdieh Mousavi, Mohammad R Rohani
BACKGROUND: The second cause of blindness in the world is glaucoma that begins with visual impairments and, in many cases, ends with irreversible visual loss. Primary open-angle glaucoma (POAG) is the most common type of glaucoma, which causes irreversible optic nerve damage in adults. Glaucoma shows an unknown etiology, but there is strong evidence regarding the role of genetic factors in disease establishment. For determination of the role of MYOC gene mutations in the development of POAG in Zahedan, Iran, screening of this gene was performed...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28792702/a-modified-combination-of-two-methods-for-isolation-of-polymorphonuclear-granulocytes-from-human-blood-for-polymerase-chain-reaction-pcr
#19
Alfredo Martinez, Robert Prizont, Rosario Anadon, Federico Klosowski
BACKGROUND: The aim of the study was to determine a rapid and simple method for isolation of polymorphonuclear (PMN) granulocytes from human blood appropriate for PCR of extracted DNA. METHODS: A modification of the combined dextran plus Ficoll-Hypaque methods was the final method used in 41 samples of normal white cells from humans. The changes encompassed a lower dextran-blood ratio (2:1), a shorter centrifugation time of leukocytes, a small volume of Ficoll-Hypaque suspension, and a decreased speed in the last centrifugation...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28792701/predictive-value-of-hepatitis-b-core-related-antigen-hbcrag-during-the-natural-history-of-hepatitis-b-virus-infection
#20
Yu Gou, Yanhua Zhao, Chenli Rao, Shu Feng, Tingting Wang, Dongdong Li, Chuanmin Tao
BACKGROUND: The natural history of HBV infection includes immune tolerance (IT), immune clearance (IC), HBeAg-negative inactive/quiescent carrier (ENQ), and HBeAg-negative hepatitis (ENH) phases. As the current biomarkers for discriminating the four phases still have some weaknesses, additional serological indicators are needed. Hepatitis B core-related antigen (HBcrAg) encoded with the precore/core gene contains denatured HBeAg, HBV core antigen (HBcAg), and a 22-KDa precore protein (p22cr) and has been demonstrated to have a close association with the natural history of hepatitis B infection...
July 1, 2017: Clinical Laboratory
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