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Clinical Laboratory

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https://www.readbyqxmd.com/read/28879725/quantification-of-renal-function-and-cardiovascular-mortality-in-patients-admitted-to-the-emergency-department-with-suspected-acute-coronary-syndromes
#1
Philipp Bahrmann, Thomas Bertsch, Evangelos Giannitsis, Michael Christ, Benjamin Hofner, Robert Christenson, Bertil Lindahl, Christian Mueller
BACKGROUND: Increases in the novel serum marker cystatin C are detectable much earlier in the course of chronic kidney disease (CKD) even when levels of serum creatinine are still in the normal range. A major factor causing a decrease in serum creatinine is increasing age. Patients with CKD are more likely to develop cardiovascular disease (CVD) than a healthy population and to suffer premature deaths from CVD related to CKD. The aim of this study was to investigate whether cystatin C, serum creatinine, and estimated glomerular filtration rate (eGFR) predict cardiovascular mortality in patients admitted to the emergency department (ED) with suspected acute coronary syndromes (ACS)...
September 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28879724/ugt1a1-gene-polymorphism-predicts-irinotecan-induced-severe-neutropenia-and-diarrhea-in-chinese-cancer-patients
#2
Hongwei Peng, Zhouping Duan, Decheng Pan, Jinhua Wen, Xiaohua Wei
BACKGROUND: Irinotecan was widely used in colon cancer and lung cancer, etc., and adverse reactions occur some times. The primary aim of this research is to investigate the association between UGT1A1 gene polymorphisms and irinotecan-related adverse effect in Chinese Han population with a novel kind of gene chip technology. METHODS: UGT1A1*6/*28 gene polymorphisms were detected by PCR and gene chip as well as sequencing. The correlation between UGT1A1 gene polymorphisms and severe delayed diarrhea or neutropenia and effect on response rate and progression-free survival were analyzed...
September 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28879723/mean-platelet-volume-and-platelet-count-are-elevated-in-patients-with-subacute-thyroiditis
#3
Zhe Fan, Shunxiong Tang
BACKGROUND: Platelet parameters have been studied in many diseases. This study explored the changes of mean platelet volume (MPV) and platelet count (PLT) in subacute thyroiditis (SAT). METHODS: We retrospectively studied 44 patients with SAT and 45 healthy individuals. Diagnosis was confirmed by pathologic examination of surgical specimens. RESULTS: There were no significant differences in age and gender between the SAT group and the control group...
September 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28879722/novel-and-simple-approach-to-estimating-the-actual-incidence-of-blood-and-body-fluid-exposure
#4
Nori Yoshioka, Matsuo Deguchi, Hideharu Hagiya, Masanori Kagita, Satomi Yukawa, Hiroko Tsukamoto, Hisao Yoshida, Norihisa Yamamoto, Yukihiro Akeda, Yoshiko Nabetani, Ikuhiro Maeda, Yoh Hidaka, Kazunori Tomono
BACKGROUND: There is no current way to determine the actual blood and body fluid exposure (BBFE) incidence in hospitals. We propose a simple, reliable, and widely available method for the accurate estimation of BBFE. METHODS: Data for BBFE for healthcare workers between 2006 and 2015 at Osaka University Hospital were retrospectively extracted from the electronic records. Annual positivity of hepatitis C virus (HCV) antibody in the source individuals and overall patient population were calculated over time...
September 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28879721/value-of-red-cell-distribution-width-in-assessing-the-severity-of-hepatitis-b-virus-related-decompensated-cirrhosis
#5
Meiyu Zhang, Siyuan Chen, Xuan Zhu, Aidan Huang, Fang Lan, Huaping Chen, Shan Li, Xue Qin
BACKGROUND: Hepatitis B virus infection is the main reason for liver cirrhosis in China. Thus, evaluating the disease severity of hepatitis B-related decompensated cirrhosis (HBV-DeCi) is very important. The red cell distribution width (RDW) is thought to be correlated with the severity of various diseases. The purpose of this investigation is to verify whether RDW can estimate the disease severity of HBV-DeCi. METHODS: This retrospective study included 172 subjects who had been diagnosed with HBV-DeCi...
September 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28879720/long-non-coding-rna-expression-signature-hallmarks-promising-efficacy-in-identification-of-human-non-small-cell-lung-cancer-a-meta-analysis-study
#6
Hongyun Yang, Yanyan Han, Lele Wu, Chaojun Wu
BACKGROUND: The long non-coding RNAs (lncRNAs) are significantly altered in an expanding list of malignant neoplasms, suggesting that they might be popularized as potential biomarkers for cancer detection. This study sought to validate the diagnostic efficacy of lncRNA expression signature(s) as potential biomarker(s) for non-small cell lung cancer (NSCLC) diagnosis. METHODS: We conducted the online databases search for all eligible studies. A quantitative meta-analysis was performed using Stata 12...
September 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28879719/interleukin-24-concentrations-not-related-with-age-but-affect-pro-and-anti-inflammatory-cytokines-differently-in-healthy-donors
#7
Yinan Shi, Qunfeng Ma, Ye Yuan, Xingdi Ma, Lingwei Kong, Yanqing Liu, Huijing Cui, Chi Zhang, Ming Wang, Xue Li, Junfeng Wang, Jianlin Ge, Zhinan Chen, Ziling Wang, Hong Jiang
BACKGROUND: Interleukin 24 (IL-24) is expressed at different levels in a variety of tumor tissues and matched normal tissues and is regarded as a potential tumor biomarker as its expression levels in tumor tissues are associated with tumor patient prognosis. At present, the expression level of IL-24 in healthy human peripheral blood is unknown. METHODS: In this study, 1940 blood samples were collected using different processing methods from healthy donors. ELISA was used to detect IL-24 concentrations...
September 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28879718/interleukin-6-receptor-il6-r-gene-polymorphisms-underlie-susceptibility-to-rheumatoid-arthritis
#8
Shoaib Ahmed, Shabbir Hussain, Ali Ammar, Shah Jahan, Shagufta Khaliq, Haiba Kaul
BACKGROUND: Increased production of interleukin 6 (IL-6) is associated with rheumatoid arthritis that acts through its receptor, IL-6R (interleukin 6 receptor). Various single nucleotide polymorphisms in the IL6R gene conferring susceptibility to rheumatoid arthritis have been identified in various populations yet these associations have not been fully established. The present study was pursued with the aim to evaluate a possible association between three single nucleotide polymorphisms (rs2228145, rs4537545, rs4845617) of the IL6R gene and rheumatoid arthritis in Pakistani patients...
September 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28879717/increased-expression-of-long-noncoding-rna-rp11-62f24-2-in-gastric-cancer-and-its-clinical-significance
#9
Cuixia Liu, Bole Cao, Ni Liu, Zhenping Zhou, Guifeng Yang, Peng Zhou
BACKGROUND: Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides and have no proteincoding capacity. In recent years, they have been believed to be major players in biological processes. However, there is limited understanding of the many lncRNAs' expressions and their clinical significances in gastric cancer. METHODS: Quantitative RT-PCR was performed to investigate the lncRNA expression in gastric cancer. Then, we further explored the potential association between RP11-62F24...
September 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28879716/concomitant-occurrence-of-blastic-plasmacytoid-dendritic-cell-neoplasm-and-acute-myeloid-leukaemia-after-lenalidomide-treatment-for
#10
Nicola S Fracchiolla, Alessanda Iurlo, Valeria Ferla, Bruno Fattizzo, Alessandra Freyrie, Gianluigi Reda, Agostino Cortelezzi
BACKGROUND: Myelodysplastic syndromes with chromosome 5 long arm deletion (5q-mds) may benefit from lenalidomide treatment. However, unresponsive patients have a high risk for clonal evolution and progression to acute myeloid leukemia. Case: We describe a 5q-patient treated with lenalidomide, who concomitantly developed acute myeloid leukemia and blastic plasmacytoid dendritic cell neoplasm, a rare and highly aggressive lymphoma. CONCLUSIONS: Evolution of 5q- syndrome to acute myeloid leukemia and blastic plasmacytoid dendritic cell neoplasm may have occurred through various mechanisms, including persistence of neoplastic lenalidomide-resistant stem cells and selection of a more aggressive clone via lenalidomide augmentation of the ARPC1B gene, or because of lenalidomide stimulation on dendritic cells...
September 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28879715/bacteremia-caused-by-campylobacter-fetus-in-a-patient-with-hepatitis-b-virus-infection-complicated-with-alcoholic-liver-cirrhosis
#11
Yili Chen, Kang Liao, Han Huang, Penghao Guo, Zhongwen Wu
Campylobacter fetus (C. fetus) bacteremia is rarely reported. In this article, a 51-year-old Chinese woman with severe hepatitis B virus infection complicated with alcoholic liver cirrhosis was admitted with a 3-month history of fatigue, jaundice, and edema of lower extremity, as well as presenting a high fever. Blood cultures were positive for Campylobacter fetus. The patient was started on treatment with cefuroxime, which was switched after 3 days to meropenem for an additional 2 weeks. The patient was successfully treated with the 3-week course of intravenous antibiotic therapy...
September 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28879714/serum-igg4-concentration-in-igg4-related-disease
#12
REVIEW
Shigeyuki Kawa, Markus Skold, David B Ramsden, Antony Parker, Stephen J Harding
BACKGROUND: IgG4-related disease (IgG4-RD) is an immune-mediated and chronic fibroinflammatory condition that affects almost any organ and often involves multiple organs in the same patient. In this review article, we address the clinical utility of measuring serum immunoglobulin G subclass 4 concentration ([IgG4]) in IgG4-RD diagnosis and in disease monitoring. METHODS: We discuss the latest literature on the relevance of [IgG4] to the investigation and management of IgG4RDs...
September 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28879713/impact-of-moderate-altitude-on-pro-inflammatory-cytokines-in-healthy-volunteers
#13
Christoph Edlinger, Catharina Schreiber, Bjoern Goebel, Rudin Pistulli, Vera Paar, Christiana Schernthaner, Ilonka Rohm, Hans-Reiner Figulla, Uta C Hoppe, Marcus Franz, Christian Jung, Michael Lichtenauer
BACKGROUND: The induction of microvascular inflammation and the effects on cytokine production in blood due to hypoxia has been shown in the past. We have previously reported a statistically significant increase of the pro-inflammatory cytokine interleukin-8 (IL-8) in normobaric hypoxia in the setting of a hypoxia-chamber. In the present study, we sought to analyze plasma levels of inflammatory cytokines in a real-life stetting in order to foster our knowledge on hypoxia induced microvascular inflammation at moderate altitude...
September 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28879712/prevalence-of-st131-and-st1193-among-bloodstream-isolates-of-escherichia-coli-not-susceptible-to-ciprofloxacin-in-a-tertiary-care-university-hospital-in-korea-2013-2014
#14
Youngjin Kim, Taesang Oh, You Sun Nam, Sun Young Cho, Hee Joo Lee
We investigated the ST distribution of bloodstream isolates of E. coli that were not susceptible to ciprofloxacin (CIP-NS isolates), collected from 2013 to 2014 in a tertiary care hospital. Fifty-nine CIP-NS isolates were collected. ST131 was the most frequent ST (37.3%) isolate, followed by ST1193 (23.7%). ST131 and ST1193 showed significant differences in ESBL production and lactose fermentation. Further study should be continued on the monitoring of resistant strains.
September 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28879711/systematic-comparison-of-igm-and-igg-abo-antibody-titers-by-using-tube-and-gel-card-techniques-and-its-relevance-for-abo-incompatible-kidney-transplantation
#15
Iman Khalili, Martina Koch, Friedrich Thaiss, Rosemarie Plaetke, Jan Bruegger, Sven Peine
BACKGROUND: Although the determination of the ABO antibody titers is necessary for the decision-making in ABOincompatible (ABOi) kidney transplantations, various methods for the determination of the ABO antibody titers are being used. However, the absence of uniform standards makes their comparability far more difficult. Two of the most commonly used methods are the tube method and the gel card method. In this study, we systematically investigate to what extent these two methods affect the result of ABO antibody titers...
September 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28879710/heat-shock-protein-90-alpha-lass-b-member-1-a-key-regulative-gene-of-monitoring-duodenal-tumor-for-obesity-induced-by-high-fat-diet
#16
Li Zheng, Jie Bai, Jin-Ling Zhang, Xia Meng, Yan-Na Hao
BACKGROUND: Effective methods of preventing and treating duodenal carcinoma, especially cancer induced by obesity (resulting from a high-fat diet) remains a longstanding challenge in medicine. METHODS: With regard to the objective, key genes were explored in the evolutional process in a group of normal, obese (high-fat diet), and duodenal tumor mice. Here, 23 genes were selected by the bioinformatics method. In order to correct the result, verification experiments were performed twice through online analysis...
September 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28879709/reference-intervals-for-fecal-calprotectin-in-adults-using-two-different-extraction-methods-in-the-uppsala-scapis-cohort
#17
Tove Fall, Aleksandra Mandic-Havelka, Johanna Helmersson-Karlqvist, Johan Sundstrom, Anders Larsson
BACKGROUND: Fecal calprotectin measurement is generally recommended to exclude inflammatory bowel disease (IBD) in patients with suspected IBD. A problem with the fecal calprotectin assays so far has been the rather long test-turnaround times. Recently a particle enhanced turbidimetric immunoassay (PETIA) for fecal calprotectin with assay times of approximately 10 minutes has been introduced on the European market. The aim of this study was to define reference intervals for adults with this new fecal calprotectin PETIA using two different extraction methods...
September 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28879708/lung-squamous-cell-carcinoma-with-de-novo-c-met-amplification
#18
Hongyang Lu, Guohua Zheng, Qi Qian
The study presented a case of lung squamous cell carcinoma (SCC) with de novo c-Met amplification. Four cycles of neoadjuvant chemotherapy were administered and partial response was achieved. Surgery was performed and the surgical margin was positive. Pathological diagnosis was lung SCC with c-ros oncogene 1 (ROS1) (+, 5%) and c-Met (++, 20%). The ROS1 rearrangement and c-Met amplification were detected using fluorescence in situ hybridization, and the result showed c-Met amplification positive and ROS1 negative...
September 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28879707/analysis-of-hepatitis-c-virus-ns5a-region-in-patients-with-cirrhosis-using-an-ultra-deep-pyrosequencing-method
#19
Fahriye Keskin, Sevgi Ciftci, Filiz Akyuz, Neslihan Abaci, Aris Cakiris, Umit Akyuz, Kadir Demir, Fatih Besisik, Duran Ustek, Sabahattin Kaymakoglu
BACKGROUND: HCV (Hepatitis C Virus) is genetically more diverse than HBV and HIV (Human Immunodeficiency Virus) and exists as quasispecies within infected individuals. This is due to the lack of efficient proofreading of the viral RNA-dependent RNA polymerase. Consequently, quasispecies emerge depending on the mutation rate of the viral polymerase, which may display a high level of genetic variability in a population. In infected individuals, HCV replicates and circulates as quasispecies composed of a complex mixture of different but closely related genomes that undergoes continuous change due to competitive selection and cooperation between arising mutants...
September 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28879706/national-survey-on-internal-quality-control-practice-for-lipid-parameters-in-laboratories-of-china-from-2014-to-2016
#20
Yuanyuan Ye, Wei Wang, Haijian Zhao, Falin He, Kun Zhong, Shuai Yuan, Zhiguo Wang
BACKGROUND: To investigate the situation of Internal Quality Control (IQC) practice for total cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol from 2014 to 2016 in laboratories in China and provide improvement measurements. METHODS: A web-based External Quality Assessment (EQA) system was used to collect IQC data of lipid parameters in laboratories which continuously participated in the national EQA programs in China from 2014 to 2016. Pass rate of the coefficients of variation (CVs) of two level quality controls in four lipid parameters were calculated according to six quality specifications for precision to evaluate the current status of precision level of the four lipid parameters and their change over time in China...
September 1, 2017: Clinical Laboratory
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