Evaluation of Oxidative Status in Patients With Chronic Periodontitis and Polycystic Ovary Syndrome: A Cross-Sectional Study.

BACKGROUND: The aim of the present study was to investigate the salivary and serum 8-hydroxy-2´-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) levels as well as total antioxidant status (TAS), in females with chronic periodontitis (CP) and polycystic ovary syndrome (PCOS), compared to healthy females.

METHODS: Four groups, each consisting of 22 individuals, respectively women with both PCOS and CP (PCOSCP), systemically healthy women with CP (CP), periodontally healthy women with PCOS (PCOSPH) and periodontally and systemically healthy women (PH). Demographic and clinical periodontal parameters were measured. Oxidative parameters were evaluated in serum and salivary samples.

RESULTS: Salivary 8-OHdG levels in the PCOSCP and CP groups were statistically higher than those in both the PCOSPH and the PH groups (p<0.05). There was no statistical difference between the PCOSCP, CP and PCOSPH groups in salivary MDA and TAS levels(p>0.05). The highest serum 8-OHdG and MDA levels and the lowest serum TAS levels were seen in the PCOSCP group (p<0.05). Serum 8-OHdG and MDA levels in the PCOSPH group were higher than those in both systemically healthy groups (PH, CP)(p<0,05). The salivary TAS levels were highest (p<0.05) in the PH group. There was no statistical difference between the CP and PCOSPH groups, but serum TAS levels were lower than those in the PH group(p<0.05).

CONCLUSIONS: CP, which led to an increase in serum and salivary 8-OHdG and MDA levels and a decrease in serum TAS levels in PCOS patients, contributed to increased oxidative stress.This effect was more prominent in serum levels than in salivary levels.