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Journal of Periodontology

Alberto Monje, Angel Insua, Mia Rakic, Jose Nart, Jose Luis Moyano-Cuevas, Hom-Lay Wang
BACKGROUND: Lack of consensus on the clinical parameters of peri-implantitis may complicate accurate diagnosis of the disorder. Furthermore, the lack of reliable estimates of the diagnostic capacity of the clinical endpoints precludes the definition of an effective treatment protocol for peri-implantitis. The present canine study assesses the diagnostic accuracy of the clinical parameters for monitoring the peri-implant tissues in a controlled ligature-induced peri-implantitis model followed by a spontaneous progression phase...
July 16, 2018: Journal of Periodontology
Sila Cagri Isler, Nihal Eraydin, Habibe Akkale, Burcu Ozdemir
BACKGROUND: Flurbiprofen which is a non-steroidal anti-inflammatory drug (NSAID), has been safely used for the control of postoperative patient's morbidity after periodontal plastic surgeries requiring palatal graft harvesting, but there is little information on the efficacy of topical use. The aim of the study was to evaluate whether patient pain perception was reduced and patient morbidity was improved by using oral spray of flurbiprofen after palatal graft harvesting. METHODS: Fortyeight patients (21 males and 27 females), scheduled for subepithelial connective tissue graft (SCTG) and free gingival graft (FGG) requiring periodontal plastic surgeries were selected...
July 14, 2018: Journal of Periodontology
Leandro Chambrone, Giovan Paolo Pini Prato
The demand for cosmetic medical treatments has increased markedly over the past few years. In Periodontology, the treatment of gingival recessions (GR), especially on anterior teeth, is being requested more and more frequently, and patient expectations are very high. This article is protected by copyright. All rights reserved.
July 14, 2018: Journal of Periodontology
Hye-Sun Shin
BACKGROUND: Handgrip strength is easily assessed by muscle strength and is an important factor for health and physical performance. Empirical evidence for the association between the number of teeth and handgrip strength remains controversial. The objective of this study was to investigate the association between the number of teeth and handgrip strength. METHODS: Data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2014-2015 were used (N = 7,741)...
July 14, 2018: Journal of Periodontology
Ishita Wanikar, Surekha Rathod, Abhay P Kolte
BACKGROUND: The treatment of molar furcation involvement is unpredictable due to the complex anatomy and poor access for instrumentation. Previous studies have reported successful regeneration with endogenous regenerative material such as platelet rich fibrin (PRF) and bisphosphonates as alendronate (ALN). Hence, the present study was aimed to evaluate clinically and radiographically the efficacy of 1% ALN gel in combination with PRF (PRF+ALN) and PRF alone in the treatment of grade II furcation defects...
July 14, 2018: Journal of Periodontology
Omnia K Tawfik, Suzi N Naiem, Lobna K Tawfik, Nermin Yussif, Mohamed M Meghil, Christopher W Cutler, Mona Darhous, Hani E El-Nahass
Lip repositioning is a conservative surgical method for the correction of excess gingival display (EGD) by limiting the upward retraction of the lips. Lip repositioning presents a simple method for the treatment of gummy smile. OBJECTIVE: The aim of this randomized clinical trial (RCT) was to assess lip repositioning, compared to lip repositioning with muscle severance for efficacy in treatment of EGD and resultant stability. METHODS: A single-blinded, controlled, parallel-group RCT was performed...
July 14, 2018: Journal of Periodontology
Bruna Di Profio, Gislene Inoue, Vanessa Costa Marui, Bruno Nunes de França, Giuseppe Alexandre Romito, Karem Lopez Ortega, Marinella Holzhausen, Claudio Mendes Pannuti
OBJECTIVE: This study aimed to compare the periodontal status of LTC with healthy controls. METHODS: Fifty liver transplant candidates (LTC group) and fifty patients without liver disease (control group) underwent a complete periodontal examination. The groups were matched according to sex, age and smoking status. A structured questionnaire was applied to record demographic data, systemic health and information related to liver disease. Full-mouth complete periodontal examination of six sites per tooth was performed: gingival recession (GR), probing depth (PD), attachment loss (AL), bleeding on probing (BOP) and visible plaque index (VPI)...
July 13, 2018: Journal of Periodontology
Ji Yeon Lee, Yoon Jeong Choi, Seong-Ho Choi, Chooryung J Chung, Hyung-Seog Yu, Kyung-Ho Kim
BACKGROUND: Labially impacted maxillary canines may lack periodontal tissue after orthodontic traction. This study evaluated the periodontal status of labially impacted maxillary canines after the closed eruption technique followed by orthodontic traction and investigated pretreatment variables affecting periodontal changes. METHODS: Patients with one labially impacted maxillary canine (impaction group) and one contralateral normal canine (control group) were selected retrospectively...
July 12, 2018: Journal of Periodontology
Amarpreet Sabharwal, Kevin Ganley, Jeffrey C Miecznikowski, Elaine M Haase, Virginia Barnes, Frank A Scannapieco
BACKGROUND: A comparison of the salivary microbiome of non-diabetic and diabetic cohorts having periodontal health, gingivitis and periodontitis could reveal microbial signatures unique to each group that will increase understanding of the role of oral microbiota in the pathogenesis of disease, and to assist with diagnosis and risk assessment for both periodontal disease and diabetes. METHODS: A group of individuals diagnosed with Type 2 diabetes (T2D) was compared to a group without T2D...
July 12, 2018: Journal of Periodontology
Xiao Li, Zhibin Zuo, Qian Chen, Jing Li, Wei Tang, Pishan Yang
BACKGROUND:  The autocrine growth factor progranulin (PGRN) plays a crucial role in the physiological and pathological processes. However, its function in chronic periodontitis (CP) remains unclear. METHODS:  Forty-five CP patients and 43 healthy controls were recruited. Expressions of PGRN in gingival biopsies were assessed by RT-qPCR and immunohistochemistry, respectively. The levels of PGRN, tumor necrosis factor alpha (TNF-α), and interleukin-1beta (IL-1β) in the gingival crevicular fluid (GCF) before and after non-surgical periodontal treatment were quantified by ELISA...
July 12, 2018: Journal of Periodontology
Nelson Pinto, Marc Quirynen
Leukocyte- and platelet-rich fibrin (L-PRF), a 2nd generation platelet concentrate, has become of great interest in periodontology (e.g. Castro et al. 2016, 2017), and extra-oral wound healing (e.g. Pinto et al. 2017). The preparation of L-PRF is based on a centrifugation process, aiming for a blood clot containing the majority of leucocytes and platelets, without the inclusion of red blood cells (Dohan et al. 2010). This article is protected by copyright. All rights reserved.
July 12, 2018: Journal of Periodontology
Jia Liu, Jiajun Zeng, Xiaoxuan Wang, Ming Zheng, Qingxian Luan
BACKGROUND: The role of reactive oxygen species (ROS) in activation of the inflammatory response has been proven in previous study using human gingival fibroblasts (HGFs) to lipopolysaccharide (LPS) from Porphyromonas gingivalis (Pg) stimulation, but its exact mechanism has not been established. ROS can be generated through increased oxidative phosphorylation. P53 originally identified as a tumor suppressor, has been demonstrated to be associated with energy metabolism. We proposed that LPS-induced inflammatory cytokines release in HGFs is mediated by interaction between P53 and ROS levels...
July 2, 2018: Journal of Periodontology
Giovanni Zucchelli, Lorenzo Tavelli, Andrea Ravidà, Stefanini Martina, Fernando Suárez-López Del Amo, Hom-Lay Wang
BACKGROUND: The efficacy of Coronally Advance Flap (CAF) has been extensively evaluated and several parameters influencing the final results, such as interproximal attachment loss, recession defect size, papilla dimension, flap thickness, have also been identified. However, the influence of tooth location has not been systematically investigated yet. Therefore, the aim of this systematic review was to evaluate the influence of tooth location on the outcomes of CAF. MATERIAL AND METHODS: A literature search on PubMed, EMBASE, Cochrane libraries and hand-searched journal until September 2017 was performed to identify clinical studies reporting the outcome of CAF for localized gingival recessions (GRs) for each single tooth...
July 2, 2018: Journal of Periodontology
A Paige Anderson, Yong-Moon Park, Deepika Shrestha, Jiajia Zhang, Jihong Liu, Anwar T Merchant
BACKGROUND: The objective of this study was to evaluate the cross-sectional association between physical activity and serum IgG antibodies against selected periodontal microorganisms. METHODS: The study population consisted of 5,611 randomly selected US adults who participated in the National Health and Nutrition Examination Survey (NHANES) III (1988 to 1994), who were 40 years and older with complete IgG antibody data against 19 oral microorganisms. We used cluster analysis to classify the 19 antibody titers into 4 mutually exclusive groups called "Orange-Red," "Red-Green," "Yellow- Orange," and "Orange-Blue," and calculated cluster scores by summing antibody titer z-scores for each of the four groups...
June 29, 2018: Journal of Periodontology
Anil Kumar, Jaideep Mahendra, Shila Samuel, Jayamathi Govindraj, Tholcopiyan Loganathan, Yaongamphi Vashum, Little Mahendra, Thiagarajan Krishnamoorthy
BACKGROUND: The study explored the effect of PRF/BCP on differentiation and survival of osteoclasts obtained from peripheral blood of CP patients. METHODS: Peripheral Blood mononuclear Cells (PBMCs) from 25 Chronic Periodontitis (CP) patients and 25 Healthy individuals were assayed for Cluster of differentiation14+ (CD14+ ) expression and monocytes were induced to differentiate into osteoclasts for 21 days in-vitro in the presence of Macrophage colony stimulating factor(M-CSF) and Receptor activator of nuclear factor-kappa B ligand (RANKL)...
June 29, 2018: Journal of Periodontology
Lucas A Reed, Nathaniel S O'Bier, Lee D Oliver, Paul S Hoffman, Richard T Marconi
BACKGROUND: Periodontal disease is a polymicrobial infection characterized by inflammation of the gingiva, alveolar bone resorption and tooth loss. As periodontal disease progresses, oral treponemes (spirochetes) become dominant bacteria in periodontal pockets. Oral treponemes are anaerobes and all encode the enzyme pyruvate-ferredoxin oxidoreductase (PFOR) which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA. Here we assess the susceptibility of oral treponemes to amixicile (AMIX), a novel inhibitor of PFOR...
June 29, 2018: Journal of Periodontology
Wenjing Li, Dong Shi, Wenli Song, Li Xu, Li Zhang, Xianghui Feng, Ruifang Lu, Xiane Wang, Huanxin Meng
BACKGROUND: Association between BMI and periodontitis were controversial. A study indicated that not only overweight/obesity but also underweight was correlated with generalized aggressive periodontitis (GAgP). However, the exact relationship between BMI and GAgP and the optimal BMI value for the lowest risk of GAgP remain unknown. OBJECTIVE: To explore the exact relationship between BMI and GAgP risk, periodontal status and WBC (white blood cell) count, and find the optimal BMI value associated with the lowest risk, periodontal status and lowest WBC of GAgP in Chinese...
June 26, 2018: Journal of Periodontology
Federica Romano, Gaia Meoni, Valeria Manavella, Giacomo Baima, Leonardo Tenori, Stefano Cacciatore, Mario Aimetti
BACKGROUND: Recent findings about the differential gene expression signature of periodontal lesions have raised the hypothesis of distinctive biological phenotypes expressed by generalized chronic periodontitis (GCP) and generalized aggressive periodontitis (GAgP) patients. Therefore, this cross-sectional investigation was planned, primarily, to determine the ability of nuclear magnetic resonance (NMR) spectroscopic analysis of unstimulated whole saliva to discriminate GCP and GAgP disease-specific metabolomic fingerprint and, secondarily, to assess potential metabolites discriminating periodontitis patients from periodontally healthy individuals (HI)...
June 7, 2018: Journal of Periodontology
Marwa M Afifi, Gehan S Kotry, Gillan I El-Kimary, Hayat A Youssef
BACKGROUND: Management of furcation defects is still a challenging subject in periodontal therapy. Drynaria fortunei (Df) is a common type of traditional Chinese herb in the area of orthopedics and traumatology. In- vitro and tissue engineering studies have shown that Df induces osteoblastic proliferation and promotes the differentiation of human periodontal ligament cells. This study investigated the management of grade II furcation defects in dogs using guided tissue regeneration (GTR) and Df granules mixed with β- tri-calcium phosphate alloplast (β- TCP)...
June 6, 2018: Journal of Periodontology
Giovan Paolo Pini Prato, Debora Franceschi, P Paolo Cortellini, Leandro Chambrone
BACKGROUND: Subepithelial connective tissue graft with coronally advanced flap (SCTG + CAF) has been considered the best and most predictable root coverage procedure. Thus, the aims of this study are twofold: 1) to evaluate the long-term outcomes following SCTG + CAF in the treatment of gingival recessions (GR) and 2) to explore the influence of several tooth/patient related factors on the stability of gingival margin at 1 year and 5,10,15,20 years after surgery. METHODS: 45 patients with 45 maxillary GR (Miller`s Class I or III) were treated with SCTG + CAF in a private practice between 1990 and 1997...
June 6, 2018: Journal of Periodontology
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