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Journal of Periodontology

Khaled Sinjab, Nouf Zimmo, Guo-Hao Lin, Ming-Pang Chung, Lujain Shaikh, Hom-Lay Wang
BACKGROUND: The use of statins on adult chronic patients showed a positive effect on their periodontal status. However, The effect of locally delivered statins on periodontal treatment has not yet been systematically analyzed. Hence, the present systematic review and meta-analyses aimed to evaluate the efficacy of statins on treating localized periodontal intrabony defects. MATERIAL AND METHODS: An electronic search of 3 databases (1965-2016 March 1(st)), including PubMed, Embase, CINAHL, and a hand search of peer-reviewed journals for relevant articles were performed...
October 21, 2016: Journal of Periodontology
Hans R Preus, Per Gjermo, Vibeke Baelum
BACKGROUND: Tooth loss is the ultimate negative consequence of periodontitis, and reports of the extent to which different treatment strategies may influence the loss of teeth in the long run are hard to find. AIM: To test the hypothesis that there is no difference in the 5-year clinical outcome of therapy in terms of tooth mortality between groups of patients treated with conventional over-weeks scaling and root planing (SRP) or same-day full-mouth disinfection (FDIS), with or without adjunctive metronidazole...
October 21, 2016: Journal of Periodontology
Agda Marobo Andreotti, Marcelo Coelho Goiato, Adhara Smith Nobrega, Emily Vivianne Freitas da Silva, Humberto Gennari Filho, Eduardo Piza Pellizzer, Daniela Micheline Dos Santos
The aim of this systematic review was to evaluate the relationship between two methods used to assess implant stability, investigating whether both provide similar implant stability assessments for the same clinical case. A literature search was conducted on MEDLINE-PubMed and Scopus databases, without limitation publication period, up to November 2015. The following key words were used, with associations among them: "dental implant", "dental implants", "Osstell", "resonance frequency analysis", "implant stability quotient", "ISQ", "Periostest", "Periotest value" and "PTV"...
October 21, 2016: Journal of Periodontology
Aliye Akcalı, Pınar Gümüş, Özgün Özçaka, Banu Öztürk-Ceyhan, Taina Tervahartiala, Heidi Husu, Anna Maria Heikkinen, Timo Sorsa, Nurcan Buduneli
OBJECTIVES: The study evaluated the levels of matrix metalloproteinase-8 (MMP-8), MMP-9, and tissue inhibitor of metalloproteinase-1 (TIMP-1) in biofluids of women with gestational diabetes mellitus (GDM) and systemically healthy counterparts with different status of periodontal health. MATERIALS & METHODS: 71 women with GDM and gingivitis (Gg), 30 women with GDM and healthy periodontium (Gh), 28 systemically and periodontally healthy women (Hh) and 37 systemically healthy women with gingivitis (Hg) were evaluated...
October 20, 2016: Journal of Periodontology
Pakchisa Khonsuphap, Prasit Pavasant, Rizky Aditya Irwandi, Chidchanok Leethanakul, Anjalee Vacharaksa
BACKGROUND: Prostaglandin E2 (PGE2) accumulates in inflamed periodontal tissue and induces the receptor activator of nuclear factor kappa-B ligand (RANKL)-RANK-osteoprotegerin (OPG) signaling associated with bone resorption. Although oral epithelial cells maintain tissue homeostasis, the role of these cells in RANKL regulation remains unknown. METHODS: To mimic inflamed condition, RANKL upregulation in human mandibular osteoblast-like cells (HMOBs) were stimulated with PGE2...
October 20, 2016: Journal of Periodontology
Şivge Kurgan, Shevali Kansal, Daniel Nguyen, Danielle Stephens, Yannis Koroneos, Hatice Hasturk, Thomas E Van Dyke, Alpdogan Kantarci
BACKGROUND: Neutrophil function is critical for the initiation and progression of infecto-inflammatory diseases. Key quorum-sensing plaque bacteria such as Fusobacterium nucleatum act as bridging species between early and late colonizer pathogens such as Porphyromonas gingivalis as the biofilm ages and periodontal inflammation increases. This study was designed to determine the impact of different F. nucleatum strains on neutrophil function. MATERIALS AND METHODS: HL-60 cells were differentiated into neutrophil-like cells and cultured with F...
October 20, 2016: Journal of Periodontology
Diego F Gualtero, Sergio M Viafara-Garcia, Sandra J Morantes, Diana M Buitrago, Octavio A Gonzalez, Gloria I Lafaurie
BACKGROUND: Rosuvastatin exhibits anti-inflammatory effects and reduces periodontal diseases and atherosclerosis; however, its role in regulating periodontopathogen-induced endothelial pro-inflammatory responses remains unclear. The purpose of this study was to determine whether rosuvastatin can reduce the pro-inflammatory response induced by A. actinomycetemcomitans in human coronary artery endothelial cells (HCAECs). METHODS: HCAECs were stimulated with purified A...
October 14, 2016: Journal of Periodontology
Po-Chun Chang, Yi-Chi Chao, Meng-Hsuan Hsiao, Hao-Syun Chou, Yi-Han Jheng, Xin-Hong Yu, Ning Lee, Connie Yang, Dean-Mo Liu
BACKGROUND: Developing a drug carrier with favorable handling characteristics that can respond to environmental changes following inflammation, such as pH changes, may be beneficial for treating periodontitis. This study aimed to investigate the preclinical feasibility of using naringin, a naturally derived polymethoxylated flavonoid compound with anti-inflammatory properties, to inhibit periodontitis induction via a thermo-gelling and pH-responsive injectable hydrogel. METHODS: The hydrogel was made of amphipathic carboxymethyl-hexanoyl chitosan (CHC), beta glycerol-phosphate (β-GP), and glycerol, and the thermo-gelling and pH-responsive characteristics of the hydrogel as well as the cell viability after treatment with the hydrogel containing naringin were evaluated in vitro...
October 14, 2016: Journal of Periodontology
Jaffer A Shariff, Kavita P Ahluwalia, Panos N Papapanou
BACKGROUND: Recreational use of cannabis following its legalization in several countries poses an emergent oral and periodontal health concern. The objective of this study was to examine the relationship between frequent recreational cannabis (marijuana and hashish) use and periodontitis prevalence among U.S adults. METHODS: Data from the National Health and Nutrition Examination Survey (NHANES 2011-12) were analyzed. The primary outcome (periodontitis) was defined using the CDC/AAP classification as well as continuous measurements of probing depth (PD) and clinical attachment loss (AL)...
October 8, 2016: Journal of Periodontology
Shruti Garg, A R Pradeep
BACKGROUND: Statins are one of the lipid lowering drugs that help in reducing cholesterol levels in the body by specifically inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase; which is a rate limiting enzyme for cholesterol synthesis. Rosuvastatin (RSV) and atorvastatin (ATV) have shown to have bone stimulatory and anti-inflammatory effects. The present study aims to explore the efficacy of 1.2% RSV and 1.2% ATV gel as a local drug delivery and redelivery system as an adjunct to scaling and root planing (SRP) for the treatment of class II furcation defects...
October 7, 2016: Journal of Periodontology
Stefan Roehling, Monika Astasov-Frauenhoffer, Irmgard Hauser-Gerspach, Olivier Braissant, Henriette Woelfler, Tuomas Waltimo, Heinz Kniha, Michael Gahlert
BACKGROUND: It has been hypothesized that zirconia might have a reduced bacterial adhesion compared to titanium; however, results from experimental studies are rather controversial. The aim of the present study was to compare biofilm formation on zirconia and titanium implant surfaces using an in vitro 3-species biofilm and human plaque samples. METHODS: Experimental disks made of titanium (Ti-M, Ti-SLA) or zirconia (ZrO2-M, ZrO2-ZLA) with a machined or a sandblasted and acid-etched surface topography were produced...
October 7, 2016: Journal of Periodontology
Ji-Young Joo, Gil Sun Cha, Jin Chung, Ju-Youn Lee, Sung-Jo Kim, Jeomil Choi
BACKGROUND: Although periodontal pathogens show a strong association with the development of atherosclerosis, little is known about how a microorganism contributes to disease onset and progression. Oxidation of low-density lipoprotein (LDL) is a major risk factor of atherogenesis. The principal objective of our study was to evaluate the ability of peptide 19 (Pep19) of Porphyromonas gingivalis (P. gingivalis) heat shock protein (HSP) as a potent inducer of LDL oxidation, and as a secondary objective, to compare this ability with that of Pep19 from different bacteria...
October 7, 2016: Journal of Periodontology
Dr Dharmendra Kanoriya, Dr A R Pradeep, Dr Vibhuti Garg, Dr Sandeep Singhal
BACKGROUND: Different materials have been instigated for renewal of lost supporting periodontal structures and tested for furcation defects treatment. Platelet-rich fibrin (PRF) is a pool of growth promoting factors and cytokines which promotes bone regeneration and maturation of soft tissue. Alendronate (ALN), an influential member of bisphosphonate group is known to enhance osteoblastogenesis and inhibits osteoclastic bone resorption, thus promoting tissue regeneration. This randomized trial was done to assess the effectiveness of PRF and 1% ALN gel combination in mandibular degree II furcation defects treatment in comparison to PRF and access therapy alone...
October 7, 2016: Journal of Periodontology
Thiago César Lima, Natália Maria Vieira-Barbosa, Camila Grasielli de Sá Azevedo, Fabiana Rodrigues de Matos, Dhelfeson Willya Douglas de Oliveira, Evandro Silveira de Oliveira, Maria Letícia Ramos-Jorge, Patricia Furtado Gonçalves, Olga Dumont Flecha
BACKGROUND: The aim of this longitudinal study was to verify changes in patients' oral health related quality of life 180 days after the treatment of dentin hypersensitivity with laser and cyanoacrylate. METHODS: This clinical, controlled, randomized, double-blind trial used a split-mouth design, and quadrants were randomized to receive either laser or cyanoacrylate treatments. All patients received both treatments. The study included 62 patients from 12-60 years of age (mean: 31...
October 7, 2016: Journal of Periodontology
Keumjin Baek, Yun Sik Choi, Cheol Keun Kang, Youngnim Choi
BACKGROUND: Porphyromonas gingivalis, a periodontal pathogen, has inter-strain variability in virulence. The aim of this study was to determine the contribution of the cell invasion ability and proteolytic activity of P. gingivalis to its virulence in a murine model of periodontitis. METHODS: Three clinical isolates, including KUMC-P1 (P1: low cell invasion ability and low proteolytic activity), KUMC-P4 (P4: low cell invasion ability and high proteolytic activity), and KUMC-P8 (P8: high cell invasion ability and low proteolytic activity), were orally administered into mice...
September 30, 2016: Journal of Periodontology
Daniel Fernando Pereira Vasconcelos, Felipe Rodolfo Pereira da Silva, Moara E Silva Conceição Pinto, Lucas de Araújo Bastos Santana, Ingrid Grazielle Souza, Luan Kelves Miranda de Souza, Natássia Cristina Martins Oliveira, Claudio Angelo Ventura, Pedro Duarte Novaes, André Luiz Dos Reis Barbosa, Jand-Venes Rolim Medeiros, Ivana Mikolasevic, Arya Mani, Jefferson Soares de Oliveira
BACKGROUND: The damages caused by periodontitis have affected not only periodontal tissues, but have also increased the severity of different illnesses such as: rheumatoid arthritis, diabetes and liver diseases. The aim of this study was to investigate the association between induced periodontitis and the damages caused through its systemic effects on the liver. METHODS: Twenty rats were divided into two groups: control and periodontitis. The following parameters were evaluated: Gingival Bleeding Index (GBI), Probing Pocket Depth (PPD), Myeloperoxidase (MPO) activity, Alveolar Bone Loss (ABL) for periodontal tissues; histopathological examination of gingival and liver tissues; immunohistochemistry to positive cell for neural/glial antigen 2 (NG2) expressed in hepatic pericytes, glutathione (GSH) and malondialdehyde (MDA) concentrations in liver; serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST)...
September 26, 2016: Journal of Periodontology
Y C M de Waal, H V L C Eijsbouts, E G Winkel, A J van Winkelhoff
BACKGROUND: Aim of this case-control study was to compare oral microbiological characteristics of subjects with healthy peri-implant conditions and subjects with peri-implantitis and to explore the influence of various patient-related and implant-related factors on the microbiological characteristics. METHODS: Peri-implant submucosal microbial samples were collected from 85 patients with peri-implantitis (cases) and from 69 patients with only implants with healthy peri-implant conditions (controls)...
September 26, 2016: Journal of Periodontology
Luiz F F Oliveira, Sérgio L Salvador, Pedro H F Silva, Flávia A C Furlaneto, Luciene Figueiredo, Renato Casarin, Edilson Ervolino, Daniela B Palioto, Sérgio L S Souza, Mario Taba, Arthur B Novaes, Michel R Messora
BACKGROUND: This study evaluated the effects of topical administration of probiotic bacteria (PROB) of the genus Bifidobacterium on experimental periodontitis (EP) in rats. METHODS: 32 rats were divided into groups C (control; without EP), EP (EP only), C-HN019 (control+PROB) and EP-HN019 (EP+PROB). On day 0 of the experiment, animals of groups EP and EP-HN019 received cotton ligatures around mandibular first molars (MFM). In groups C-HN019 and EP-HN019, 1mL of suspensions containing Bifidobacterium animalis subsp lactis (B...
September 23, 2016: Journal of Periodontology
Young-Dan Cho, Bong-Soo Kim, Chang-Seok Lee, Kyung-Hwa Kim, Yang-Jo Seol, Yong-Moo Lee, In-Chul Rhyu, Young Ku, Hyun-Mo Ryoo
BACKGROUND: In our previous studies, we demonstrated that a fibronectin (FN)-derived oligopeptide termed F20 stimulates osteoblast differentiation in vitro and bone formation in vivo. However, the fundamental molecular mechanism by which F20 stimulates osteogenesis remains unknown. Therefore, in this study we investigated the molecular mechanism underlying the effect of F20 in osteoblast differentiation. METHODS: The role of F20 in osteoblast differentiation was examined using the mouse bone-marrow-derived ST2 cell line...
September 13, 2016: Journal of Periodontology
Jamal Hassan Assaf, Débora do Canto Assaf, Raquel Pippi Antoniazzi, Leandro Berni Osório, Fabiana Mantovani Gomes França
BACKGROUND: The aim of the study was to evaluate a new technique for treating dehiscence buccal bone sites (Class 2) with immediate implant and collagen-enriched bovine-derived xenograft blocks without a surgical flap or membrane. MATERIALS AND METHODS: Individuals with at least 5 mm of buccal bone dehiscence were selected for a flapless surgical approach to insert xenografts blocks into buccal dehiscence defects as well as the gap between the implant and the residual bone wall...
September 13, 2016: Journal of Periodontology
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