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Journal of Periodontology

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https://www.readbyqxmd.com/read/30653263/molecular-signatures-of-chronic-periodontitis-in-gingiva-a-genomic-and-proteomic-analysis
#1
Esra Guzeldemir-Akcakanat, Begum Alkan, Deniz Sunnetci-Akkoyunlu, Busra Güral, V Merve Balta, Bahadir Kan, Emel Akgun, Elif Busra Yilmaz, Ahmet Tarik Baykal, Naci Cine, Vakur Olgac, Esen Gumuslu, Hakan Savlı
BACKGROUND: To elucidate molecular signatures of chronic periodontitis (CP) using gingival tissue samples through omics-based whole-genome transcriptomic and whole protein profiling. METHODS: Gingival tissues from 18 CP and 25 controls were analysed using gene expression microarrays to identify gene expression patterns and the proteins isolated from these samples were subjected to comparative proteomic analysis by LC-MS/MS. The data from transcriptomics and proteomics were integrated to reveal common shared genes and proteins...
January 17, 2019: Journal of Periodontology
https://www.readbyqxmd.com/read/30648265/the-effect-of-different-gingival-phenotypes-on-dimensional-stability-of-free-gingival-graft-a-comparative-6-month-clinical-study
#2
Serap K Akcan, Berceste Güler, Hasan Hatipoğlu
BACKGROUND: The aim of this study is to compare the effect of mesial and distal adjacent gingival phenotypes of the tooth / teeth region of free gingival graft (FGG) on the shrinkage ratio of graft at 6 months postoperatively. METHODS: Thirty-one patients had suffered from inadequate keratinized gingival width (KGW) around mandibular incisors were included this study. The phenotype of the mesial and distal terminal teeth was evaluated by the probe transparency method and keratinized gingival thickness measurements; study groups were divided as thick and thin phenotype...
January 15, 2019: Journal of Periodontology
https://www.readbyqxmd.com/read/30644104/periodontal-ligament-derived-mesenchymal-stem-cells-modulate-neutrophil-responses-via-paracrine-mechanisms
#3
Mônica Yuri Orita Misawa, Karina Gonzales Silvério Ruiz, Francisco Humberto Nociti, Mayra Laino Albiero, Miki Taketomi Saito, Rafael Nóbrega Stipp, Antônio Condino-Neto, Marinella Holzhausen, Henrique Palombo, Cristina Cunha Villar
BACKGROUND: Mesenchymal stem cells differentiate into distinct mesenchymal cell lineages and regulate the immune response. The aim of this study was to determine whether periodontal ligament-derived mesenchymal stem cells (PDLSCs) have the ability to modulate neutrophil responses via paracrine mechanisms. METHODS: CD105-enriched PDLSCs were seeded for 24h and challenged with Porphyromonas gingivalis total protein extract (PgPE) (0 or 2ug/ml) for 3h. Cells were then washed and further cultured for 18h and the supernatants were collected and stored...
January 15, 2019: Journal of Periodontology
https://www.readbyqxmd.com/read/30644101/retrospective-cohort-study-of-4591-dental-implants-analysis-of-risk-indicators-for-bone-loss-and-prevalence-of-peri-implant-mucositis-and-peri-implantitis
#4
David French, H Michelle Grandin, Ronen Ofec
BACKGROUND: Due to the risk of peri-implantitis, following dental implant placement, this study aimed to evaluate risk indicators associated with marginal bone loss from a retrospective open cohort study of 4591 dental implants, placed in private practice, with 5 to 10-year follow-up. Furthermore, the prevalence of mucositis and peri-implantitis among the study cohort was evaluated, comparing strict versus relaxed criteria for bleeding on probing. MATERIALS AND METHODS: Periapical radiographs were used to evaluate changes in crestal bone level...
January 15, 2019: Journal of Periodontology
https://www.readbyqxmd.com/read/30637748/platelet-derived-growth-factor-bb-levels-in-gingival-crevicular-fluid-of-localized-intrabony-defect-sites-treated-with-platelet-rich-fibrin-membrane-or-collagen-membrane-containing-recombinant-human-platelet-derived-growth-factor-bb-a-randomized-clinical-and
#5
Amruta A Joshi, Ashvini M Padhye, Himani S Gupta
BACKGROUND: Development of autologous and recombinant growth factor/matrix combination products represent a new emerging trend in regenerative therapeutics and have gained increasing attention as a strategy to optimize tissue regeneration. The aim of the present study was to evaluate the levels of Platelet derived growth factor BB (PDGF-BB) in gingival crevicular fluid (GCF) during early healing period after the regenerative treatment of intrabony defects using beta tricalcium phosphate (β-TCP) as a bone regeneration material with either platelet rich fibrin (PRF) membrane or collagen membrane (CM) treated with recombinant human PDGF-BB (rhPDGF-BB)...
January 13, 2019: Journal of Periodontology
https://www.readbyqxmd.com/read/30632612/photodynamic-therapy-versus-systemic-antibiotic-for-the-treatment-of-periodontitis-in-a-rat-model
#6
Jianxing Zhang, Hui Liang, Yixin Zheng, Dongcai Wang, Jiang Xia, Wenming Peng, Kangjie Cheng, Lianfei Wang, Yunfeng Liu, Wei Peng, Qingyong Li
BACKGROUP: To compare the therapeutic effect of photodynamic therapy (PDT) with Toluidine blue O hydrogel versus systemic antibiotic (SA) in treating periodontitis on rats. METHODS: Thirty-two Wistar rats were divided into 4 groups and treated differently: Negative Control (NC) group, normal rats; Positive Control (PC) group, rats with periodontitis; SA group, rats with periodontitis treated with systemic antibiotic; PDT group, rats with periodontitis treated with PDT...
January 11, 2019: Journal of Periodontology
https://www.readbyqxmd.com/read/30632606/reshapeable-hydrogel-tissue-expander-for-ridge-augmentation-results-of-a-series-of-successive-insertions-at-the-same-intraoral-site
#7
John Garner, Darrell D Davidson, Daria Barwinska, George J Eckert, Sunil S Tholpady, Kinam Park, Clark T Barco
BACKGROUND: Tissue expansion of oral mucosa prior to ridge augmentation promises to reduce the soft tissue exposure and improve the final intraoral bone graft density and volume. This study explored a novel, shapeable hydrogel tissue expander (HTE) in intraoral sites that had undergone previous expansion and surgery. METHODS: Nine beagle dogs had all premolar teeth extracted with alveolar bone reduction. At least 3 months healing followed before placing the hydrogels at 4 sites for each dog: maxilla and mandible, right and left...
January 11, 2019: Journal of Periodontology
https://www.readbyqxmd.com/read/30618100/dysregulation-of-mir-146a-by-periodontal-pathogens-a-risk-for-acute-coronary-syndrome
#8
Gita J Bagavad, Ann V George, N Pavithra, S C Chandrasekaran, K Latchumanadhas, A Gnanamani
BACKGROUND: Periodontitis is a polymicrobial, chronic inflammatory disease leading to loss of tooth-supporting structures. The bacteremia, endotoxemia, and systemic low-grade inflammation associate periodontitis with systemic illnesses such as diabetes mellitus and coronary artery disease. Periodontal pathogens have been detected from atheromatous plaque by amplification of the genetic material by using specific oligonucleotide primers in polymerase chain reaction. Though the association between periodontitis and cardiovascular diseases has been ascertained by systematic reviews and meta-analyses, its pathophysiology is not lucid...
January 7, 2019: Journal of Periodontology
https://www.readbyqxmd.com/read/30578550/buccal-bone-thickness-adjacent-to-virtual-dental-implants-following-guided-bone-regeneration
#9
Daniel J Phillips, Dane T Swenson, Thomas M Johnson
BACKGROUND: Crestal bone thickness is a critical determinant of peri-implant tissue stability. This retrospective observational study sought to quantify the buccal bone thickness achieved adjacent to virtual dental implants following guided bone regeneration (GBR) surgery and evaluate the influence of patient- and procedure-related variables on buccal bone thickness. METHODS: Cone-beam computed tomography (CBCT) images acquired from patients who had undergone GBR surgery between July 1, 2012, and November 7, 2016, were utilized for this analysis...
December 21, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/30565232/exploring-a-temporal-relationship-between-biofilm-microbiota-and-inflammatory-mediators-during-resolution-of-naturally-occurring-gingivitis
#10
Simon J Stone, Purnima S Kumar, Steven Offenbacher, Peter A Heasman, Giles I McCracken
BACKGROUND: This study uses multiple, contemporary methodologies to expand our knowledge of the temporal relationship between host-microbial interactions and clinical signs of gingivitis. METHODS: Subgingival plaque and crevicular fluid samples were collected from 31 systemically healthy adults with naturally occurring plaque-induced gingivitis. Professional prophylaxis was administered and participants were followed over seven weeks. Microbial characterization was performed using a bead-based hybridization assay and cytokine analysis using bead-based flow cytometry...
December 19, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/30549272/angiogenin-production-in-response-to-hypoxia-and-l-mimosine-in-periodontal-fibroblasts
#11
Klara Janjić, Peter Bauer, Michael Edelmayer, Barbara Cvikl, Barbara Schädl, Andreas Moritz, Hermann Agis
BACKGROUND: A major mediator of angiogenesis is angiogenin which is expressed in the early phase of healing in oral tissue engineering strategies. It is unclear how angiogenin is regulated in the periodontal tissue. The objective of this study was to reveal the regulation of angiogenin in response to hypoxia and the hypoxia mimetic agent L-mimosine in periodontal fibroblasts METHODS: Human fibroblasts of the periodontal ligament (PDLF) and the gingiva (GF) in monolayer and spheroid cultures were exposed to hypoxia or L-mimosine...
December 14, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/30549271/cytokine-chemokine-and-growth-factor-levels-in-peri-implant-sulcus-during-wound-healing-and-osseointegration-after-piezosurgical-versus-conventional-implant-site-preparation-randomized-controlled-split-mouth-trial
#12
Ali Gürkan, Gözde Peker Tekdal, Nagihan Bostancı, Georgios N Belibasakis
AIM: To evaluate the cytokine, chemokine and growth factor levels in peri-implant sulcular fluid (PISF) during healing and osseointegration at osteotomy sites prepared either with piezosurgery (PS) or drills. MATERIALS AND METHODS: Fourteen patients having contralateral partial edentulism in the posterior maxilla were enrolled and 38 osteotomies were prepared. Implants were placed with one-stage surgery. Insertion torque, early healing index, probing depth and modified gingival and plaque indices and crestal bone loss (CBL) were measured...
December 14, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/30548930/the-effect-of-diabetes-on-tooth-loss-due-to-periodontal-disease-a-nationwide-population-based-cohort-study-in-south-korea
#13
Jin-Joo Yoo, Dong-Wook Kim, Man-Yong Kim, Young-Taek Kim, Joon-Ho Yoon
BACKGROUND: Our purpose was to compare the risk of tooth loss due to periodontal disease between diabetic and non-diabetic individuals and to estimate the relative risk of tooth loss according to the severity and control of diabetes. METHODS: We selected 10,215 individuals who diagnosed as diabetes in the Korean National Health Insurance Service - National Sample Cohort (NHIS-NSC) database in 2003 and the same number of individuals who had never been diagnosed with diabetes during the period covered by the NHIS-NSC (2002-2013) with propensity score matching...
December 13, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/30548620/necessity-for-standardization-of-relative-centrifugal-force-values-in-studies-on-platelet-rich-fibrin-response-to-letter-to-the-editor
#14
LETTER
Richard J Miron, Joseph Choukroun, Shahram Ghanaati
No abstract text is available yet for this article.
December 13, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/30536725/gingival-crevicular-fluid-and-salivary-hif-1%C3%AE-vegf-and-tnf-%C3%AE-levels-in-periodontal-health-and-disease
#15
Beral Afacan, Veli Özgen Öztürk, Çiğdem Paşalı, Emir Bozkurt, Timur Köse, Gülnur Emingil
AIM: Hypoxia-inducible factor-1 alpha (HIF-1α) is expressed as an adaptive response to hypoxia, mediates angiogenesis through the expression of vascular endothelial growth factor (VEGF) and can be induced by tumor necrosis factor-alpha (TNF-α). This study aimed to investigate the gingival crevicular fluid (GCF) and salivary HIF-1α, VEGF, and TNF-α levels in periodontal health and disease. METHODS: A total of 87 individuals, 20 generalized aggressive periodontitis (G-AgP), 20 chronic periodontitis (CP), 26 gingivitis patients, and 21 periodontally healthy individuals, were included...
December 11, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/30536765/interleukin-17-producing-t-cells-and-interleukin-17-mrna-expression-in-periodontitis-and-longstanding-gingivitis-lesions
#16
Sara Thorbert-Mros, Lena Larsson, Josephine Kalm, Tord Berglundh
BACKGROUND: T helper17 cells (Th17) are key targets in the evaluation of differences between "destructive" and "non-destructive" periodontal lesions. The aim of the present study was to analyze the density of interleukin-17 (IL-17) producing T cells and IL-17 mRNA expression in lesions representing severe periodontitis and longstanding gingivitis. METHODS: Two groups of patients were recruited. The gingivitis group consisted of 28 patients, 41-70 years old, with evident signs of gingival inflammation but no attachment loss...
December 7, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/30517975/a-randomized-clinical-trial-of-cyanoacrylate-tissue-adhesives-in-donor-site-of-connective-tissue-grafts
#17
Chrysi Stavropoulou, Reem N Atout, Meredith Brownlee, Robert J Schroth, Anastasia Kelekis-Cholakis
BACKGROUND: The purpose was to compare patient-centered outcomes, early wound healing and post-operative complications at palatal donor area of subepithelial connective tissue grafts (CTG) between cyanoacrylates tissue adhesives and Polytetrafluoroethylene (PTFE) sutures. METHODS: 36 patients who required harvesting of CTG were enrolled in this randomized clinical trial and assigned to one of two groups. In the "suture" group, wound closure was achieved with standardized continuous interlocking 6-0 PTFE sutures, while in the "cyanoacrylate" group, a high viscosity blend of n-butyl and 2-octyl cyanoacrylate was applied until hemostasis was achieved...
December 5, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/30517775/pattern-recognition-receptor-polymorphisms-in-early-periodontitis
#18
Fábio R M Leite, Christian Enevold, Klaus Bendtzen, Vibeke Baelum, Rodrigo López
BACKGROUND: Even though bacteria trigger inflammation, most of the tissue destruction in periodontitis is due to the host inflammatory response. In addition to immunological events that drive development of early periodontitis, numerous environmental factors like genetics and smoking play a role. We investigated whether the carriage of selected single nucleotide polymorphisms (SNP) of toll-like receptors (TLR), NOD-like receptors (NLR) and RIG-I-like receptors (RLR) was associated with the diagnosis of early periodontitis in a case-control study...
December 5, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/30506795/effects-of-statins-on-multispecies-oral-biofilm-identify-simvastatin-as-a-drug-candidate-targeting-porphyromonas-gingivalis
#19
Marta Kamińska, Ardita Aliko, Annelie Hellvard, Ewa Bielecka, Veronika Binder, Agata Marczyk, Jan Potempa, Nicolas Delaleu, Tomasz Kantyka, Piotr Mydel
BACKGROUND: Statins effectively reduce risk of cardiovascular-related morbidity and mortality in patients with hyperlipidemia, hypertension or type-II diabetes. In addition to lowering cholesterol levels, several studies have attributed statins with immunomodulatory and bactericidal properties. Therefore, the aim of this study was to investigate statins' antimicrobial activity against relevant for periodontal homeostasis bacteria. METHODS: Statin effect on bacterial growth was tested using planktonic monocultures and multibacterial biofilms...
December 2, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/30499115/membrane-proteome-characterization-of-periodontal-ligament-cell-sets-from-deciduous-and-permanent-teeth
#20
Priscila A Giovani, Cristiane R Salmon, Luciane Martins, Adriana F P Leme, Regina M Puppin-Rontani, Luciana S Mofatto, Francisco H Nociti, Kamila R Kantovitz
BACKGROUND: Physiological roles for the periodontal ligament (PDL) include tooth eruption and anchorage, force absorption, and provision of proprioceptive information. Despite the advances in understanding the biology of PDL cells, there is a lack of information regarding the molecular signature of deciduous (DecPDL) and permanent (PermPDL) PDL tissues. Thus, the present study was designed to characterize the membrane proteome of DecPDL and PermPDL cells. METHODS: Primary PDL cells were obtained (n = 6) and a label-free quantitative proteome of cell membrane-enriched components was performed...
November 29, 2018: Journal of Periodontology
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