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Journal of Periodontology

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https://www.readbyqxmd.com/read/28523955/collaborative-cross-mouse-population-for-studying-the-alveolar-bone-changes-and-impaired-glucose-tolerance-comorbidity-after-high-fat-diet-consumption
#1
Aysar Nashef, Hanifa J Abu-Toamih Atamni, Yuval Buchnik, Hatice Hasturk, Alpdogan Kantarci, Danielle Stephens, Ervin I Wiess, Yael Houri-Haddad, Fuad A Iraqi
BACKGROUND: High-fat diet (HFD), body weight (BW) gain and impaired glucose tolerance development were associated with alveolar bone loss in susceptible individuals. This report explores the Collaborative Cross (CC) mouse population for studying the impact of genetic background on the comorbidity of alveolar bone change and glucose tolerance following HFD consumption. METHODS: 78 mice from 19 different CC lines were maintained on rodents chow diet (CH) for 8 weeks, and subsequently, transferred to HFD (42% Fat) for an additional 12 weeks...
May 19, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28523954/photometric-cielab-analysis-of-the-gingiva-a-novel-approach-to-assess-response-to-periodontal-therapy
#2
Yaniv Mayer, Ofir Ginesin, Eli E Machtei
OBJECTIVE: A new photometric method is introduced for the assessment of the gingival condition and changes following periodontal therapy. MATERIAL AND METHODS: Clinical data (probing depth, plaque index, gingival index, bleeding on probing, clinical attachment level) and photographs from 53 subjects (49% males, 51% females) undergoing initial periodontal treatment were used for this analysis. Each maxillary anterior area was photographed before treatment and three months after...
May 19, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28517975/relationship-between-periodontal-screening-and-recording-index-scores-and-need-for-periodontal-access-surgery
#3
Thomas E Rams, Walter J Loesche
BACKGROUND: The validity of using pretreatment Periodontal Screening and Recording (PSR) index sextant scores to estimate periodontal access surgery needs was evaluated in chronic periodontitis patients both before and after the completion of non-surgical periodontal therapy. METHODS: In 110 adults, pretreatment probing data identified 486 sextants with PSR scores of 4, and 125 sextants with PSR scores of 3. Periodontal access surgery needs in each sextant were determined prior to treatment by two experienced periodontist examiners, and also after completion of non-surgical periodontal therapy for 213 sextants in 38 patients...
May 18, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28517974/the-impact-of-docosahexaenoic-acid-therapy-on-subgingival-plaque-microbiota
#4
Asghar Z Naqvi, Lin Mu, Hatice Hasturk, Thomas E Van Dyke, Kenneth J Mukamal, J Max Goodson
OBJECTIVE: The aim of this study was to evaluate the impact of docosahexaenoic acid (DHA) with low-dose aspirin therapy on periodontal bacterial profile in patients with periodontitis. BACKGROUND: We recently showed that oral DHA + aspirin therapy reduces periodontal pocket depth and local inflammatory mediators in gingival crevicular fluid (GCF) among patients with untreated chronic periodontal disease. Whether or not DHA + aspirin therapy influences specific bacterial burden in this setting is unknown...
May 18, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28517973/periodontal-referral-patterns-in-australia-2000-versus-2015
#5
Leah M Brown, Patrick Bowman, Vincent J O'Rourke, Faustino Mercado, Roderick Marshall, Scott Parsons
BACKGROUND: A previous study had investigated differences in the severity of periodontal disease on referral for specialist care between 1980 and 2000 across the USA. This study found patients referred in 2000 had a greater severity of periodontal disease than those referred twenty years prior. METHODS: A retrospective chart analysis of 384 charts was completed from three periodontal practices across the east coast of Australia. Two time periods were investigated; 2000-2001 and 2015-2016...
May 18, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28517972/glycated-collagen-stimulates-the-differentiation-of-gingival-myofibroblasts
#6
Ignacio N Retamal, Romina Hernández, Francisco Melo, Paulina Zapata, Constanza Martínez, Jorge Martínez, Patricio C Smith
BACKGROUND: Glucose-derived metabolites may alter the structure and biological properties of important proteins in the periodontium such as collagens. As a consequence, it is possible that collagen-binding cells may change their phenotypic traits. Though the glucose derived product methylglyoxal has been detected in periodontal lesions, the precise effect of collagen glycation on gingival connective tissue biology is far from being understood. In the present study we have evaluated whether collagen glycation by methylglyoxal may affect the phenotypic properties and remodeling capacity of human gingival fibroblasts...
May 18, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28517971/soft-tissue-changes-around-immediately-placed-implants-a-systematic-review-and-meta-analyses-with-at-least-12-months-follow-up-after-functional-loading
#7
Bassam M Kinaia, Filip Ambrosio, Periodontal Resident, Monica Lamble, Periodontal Resident, Kristyn Hope, Periodontal Resident, Maanas Shah, Anthony L Neely
BACKGROUND: Immediate implant placement (IIP) is predictable but can lead to esthetic challenges including mid-facial recession (MFR) and papillary height (PH) loss. The focused question of this systematic review was: What is the effect of IIP on MFR and PH after at least 12-months of functional loading? METHODS: Literature review of the COCHRANE and MEDLINE electronic databases and hand search up to January 2016 identified eligible studies. Four reviewers independently assessed data quality and methodology...
May 18, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28517970/osteoblast-progenitors-enhance-osteogenic-differentiation-of-periodontal-ligament-stem-cells
#8
Miao Yu, Limei Wang, Pengfei Ba, Linxia Li, Long Sun, Xiaoqi Duan, Pishan Yang, Chengzhe Yang, Qinfeng Sun
BACKGROUND: Osteoblasts and periodontal ligament stem cells (PDLSCs) play an important role in maintaining physiological function of periodontal tissues and participating in periodontal regeneration. Elucidation of interactions between osteoblasts and PDLSCs will aid understanding of periodontal regeneration mechanisms. This study aimed to determine whether pre-osteoblasts can promote osteoblastic/cementoblastic differentiation of PDLSCs. METHODS: PDLSCs were cultured alone (control group), or co-cultured indirectly with human gingival fibroblasts (HGFs) (HGFs group) or MC3T3-E1 cells (OB groups)...
May 18, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28492362/microbiota-analysis-of-biofilms-on-experimental-abutments-mimicking-dental-implants-an-in-vivo-model
#9
Berta Cortés-Acha, Rui Figueiredo, Ramón Seminago, Francisco J Roig, Carlos Llorens, Eduard Valmaseda-Castellón
BACKGROUND: The microbiota colonizing dental implants has been said to be similar to the microbiome surrounding teeth. In the absence of inflammation, a biofilm with pathological bacteria can cover implant surfaces exposed to the oral cavity, due for example, to a remodeling process. The aim of the present study was to identify the microbiota surrounding exposed dental implants in patients with and without a history of periodontitis through a deep-sequencing approach. METHODS: An experimental abutment with the same surface and structure as a commercially available dental implant was used...
May 11, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28492361/influence-of-rs2228570-on-transcriptional-activation-by-the-vitamin-d-receptor-in-human-gingival-fibroblasts-and-periodontal-ligament-cells
#10
Kaining Liu, Bing Han, Huanxin Meng, Jianxia Hou
BACKGROUND: Rs2228570 is the only known single nucleotide polymorphism of the vitamin D receptor (VDR) that alters the protein structure. VDRs can be distinguished using the restriction endonuclease FokI, and accordingly divided into three genotypes: FF, Ff and ff. The influence of rs2228570 on transcriptional activation by VDR in human gingival fibroblasts (hGFs) and periodontal ligament cells (hPDLCs) was investigated in this study. METHODS: hGFs and hPDLCs from 15 donors were cultured, genomic DNA was extracted, and genotypes were determined using the PCR-RFLP method...
May 11, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28492360/resveratrol-inhibits-periodontitis-related-bone-loss-in-rats-submitted-to-cigarette-smoke-inhalation
#11
Fernanda V Ribeiro, Danilo S Pino, Felipe C Franck, Bruno B Benatti, Howard Tenenbaum, Dip Perio, John E Davies, Suzana P Pimentel, Renato C Casarin, Fabiano R Cirano, Marcio Z Casati
BACKGROUND: Alternative therapeutic approaches have been explored in order to modulate the host's response to periodontal disease. The knowledge of new strategies to treat periodontitis is particularly relevant in patients presenting augmented risk to periodontitis, as smokers. The aim of this study was to investigate the impact of Resveratrol (RESV) on the progression of experimental periodontitis (EP) in the presence of cigarette smoke inhalation (CSI). METHODS: Rats were assigned to: CSI+RESV(n=20); CSI+placebo(n=20); Non-CSI(n=20)...
May 11, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28492359/periodontitis-and-endothelial-dysfunction-periodontal-clinical-parameters-and-the-levels-of-salivary-markers-il-1%C3%AE-tnf-%C3%AE-mmp2-timp2-complex-and-nitric-oxide
#12
Marcela Faria Moura, Túlio Pinho Navarro, Tarcília Aparecida Silva, Luís Otávio Miranda Cota, Alcione Maria Soares Dutra Oliveira, Fernando Oliveira Costa
BACKGROUND: Periodontitis has been associated with a greater risk for arteriosclerotic cardiovascular disease (ACD). Endothelial dysfunction (ED) is a parameter of early ACD, and its association with periodontitis has rarely been investigated to date. The objective of this study was to evaluate the association between periodontitis and ED by means of periodontal clinical parameters and salivary markers IL-1β, TNF-α, nitric oxide-(NO) and MMP2/TIMP2 complex. METHODS: Forty-seven individuals were divided into two groups: 24 individuals with chronic periodontitis and 23 individuals without chronic periodontitis...
May 11, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28474968/additive-effect-of-plasma-rich-in-growth-factors-with-guided-tissue-regeneration-in-treatment-of-intrabony-defects-in-chronic-periodontitis-patients-a-split-mouth-randomized-controlled-clinical-trial
#13
Sheethalan Ravi, Sankari Malaiappan, Sheeja Varghese, N D Jayakumar, Gopinath Prakasam
BACKGROUND: Periodontal regeneration can be defined as the complete restoration of lost periodontal tissues to their original architecture and function. Variety of treatment modalities have been proposed to achieve it. Plasma rich in growth factors (PRGF) is a concentrated suspension of growth factors that promotes restoration of the lost periodontal tissues. The objective of the present study was to assess the effect of Plasma rich in growth factors (PRGF) associated with Guided Tissue regeneration (GTR) versus GTR only in the treatment of intrabony defects in chronic periodontitis patients...
May 5, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28474967/salivary-colony-stimulating-factor-1-interleukin-34-and-matrix-metalloproteinase-8-as-markers-of-periodontal-disease
#14
G L Martinez, M Majster, N Bjurshammar, A Johannsen, C M Figueredo, E A Boström
BACKGROUND: Colony-stimulating factor (CSF)-1 and interleukin (IL)-34 are macrophage growth factors and regulators of osteoclastogenesis. The potential involvement of CSF-1 and IL-34 in periodontal disease is yet unknown. The aim of this study was to explore the presence of CSF-1 and IL-34 in whole saliva in relation to periodontal disease. METHODS: Protocol validation was assessed in saliva of healthy donors (n=21) by ELISA. Salivary CSF-1, IL-34, and matrix metalloproteinase (MMP)-8, a biomarker candidate of periodontitis, were determined in 48 patients (29 periodontitis, 12 gingivitis, 7 healthy) and related to the clinical periodontal parameters bleeding on probing (BOP), probing depth (PD), clinical attachment loss (AL), and plaque index (PI)...
May 5, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28452623/advantages-of-autologous-platelet-rich-fibrin-membrane-on-gingival-crevicular-fluid-growth-factor-levels-and-periodontal-healing-a-randomized-split-mouth-clinical-study
#15
Taner Arabaci, Oguz Kose, Mevlut Albayrak, Yasin Cicek, Alper Kizildag
AIM: To evaluate the contributions of platelet rich fibrin (PRF) combined with conventional flap surgery on the growth factor levels in gingival crevicular fluid (GCF) and periodontal healing. MATERIALS AND METHOD: 26 patients (52 sites) with chronic periodontitis were treated either with autologous PRF with open flap debridement (OFD+PRF) or open flap debridement (OFD) alone. Growth factor levels in GCF at baseline and 2, 4 and 6 weeks postoperatively were analyzed, and clinical parameters such as probing depth (PD), relative attachment level (RAL) and gingival margin level (GML) at baseline and 9 months after surgery were compromised...
April 28, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28452622/histologic-evaluation-of-wound-healing-following-ridge-preservation-with-cortical-cancellous-and-combined-cortico-cancellous-freeze-dried-bone-allograft-a-randomized-controlled-clinical-trial
#16
Randy S Demetter, Blaine G Calahan, Brian L Mealey
BACKGROUND: Cortical and cancellous mineralized freeze-dried bone allografts (FDBA) are available for use in alveolar ridge preservation after tooth extraction. There are currently no data regarding the use of a combination 50/50% cortico-cancellous FDBA compared to a 100% cortical or 100% cancellous FDBA in ridge preservation. The primary objective of this study is to dimensionally and histologically evaluate healing following ridge preservation in non-molar sites using 50/50% cortico-cancellous FDBA versus 100% cortical and 100% cancellous FDBA...
April 28, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28452621/the-number-of-teeth-is-inversely-associated-with-metabolic-syndrome-a-korean-nationwide-population-based-study
#17
Hye-Sun Shin
BACKGROUND: The objectives of this research are to determine the relationship between the number of natural teeth and metabolic syndrome (MetS) in a representative sample of the Korean population. METHODS: From the Korea National Health and Nutrition Examination Survey, a cross- sectional study was conducted on 13,066 participants over the age of 19 years. The number of teeth was assessed by clinical oral examination. MetS was defined based on the Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention...
April 28, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28452620/effect-of-intensive-periodontal-therapy-on-blood-pressure-and-endothelial-microparticles-in-prehypertensive-patients-with-periodontitis-a-randomized-controlled-trial
#18
Qian-Bing Zhou, Wen-Hao Xia, Jing Ren, Bing-Bo Yu, Xin-Zhu Tong, Yan-Bin Chen, Shan Chen, Lei Feng, Jing Dai, Jun Tao, Jun-Ying Yang
BACKGROUND: Although some studies show the positive association between periodontitis and blood pressure (BP) elevation, the effect of intensive periodontal treatment on decline in BP levels and endothelial microparticles (EMPs) without any antihypertensive management is lacking. Therefore, we conducted an intervention clinical trial to explore whether intensive periodontal therapy would lower BP levels and EMPs of prehypertensive patients with periodontitis. METHODS: A total 107 patients underwent randomization, of whom 95 (47 assigned to the Control-treatment group and 48 to the Intensive-treatment group) completed the trial...
April 28, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28440743/targeting-underlying-biologic-mechanisms-in-selecting-adjunctive-therapies-to-improve-periodontal-treatment-in-smokers-a-commentary
#19
Maria L Geisinger, Nicolaas C Geurs, Dorothy Ogdon, Michael S Reddy
Despite well-established evidence that cigarette smoking is the largest modifiable risk factor for periodontal disease and has many deleterious health effects, the treatment of periodontal disease in smokers remains a challenge of periodontal therapy. A recent meta-analysis revealed that the adjunctive use of local delivery of antimicrobials, but not systemic antibiotic usage, with nonsurgical periodontal therapy resulted in an improvement in clinical periodontal parameters. Further evaluation of the current literature reveals that host modulation therapy may also result in a clinical benefit in smokers...
April 25, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28440742/leptin-overexpression-in-bone-marrow-stromal-cells-promotes-periodontal-regeneration-in-a-rat-model-of-osteoporosis
#20
Baoyu Zheng, Jun Jiang, Yuling Chen, Minkui Lin, Zhibin Du, Yin Xiao, Kai Luo, Fuhua Yan
BACKGROUND: Osteoporosis (OP) is associated with widespread periodontitis and impaired periodontal healing. However, there is a lack of information about the outcomes of regenerative approaches under the influence of OP. This study investigated the effect of leptin (LEP) overexpression on the regenerative potential of bone marrow stromal cells (BMSCs) in an osteoporotic rat periodontal fenestration defect model. METHODS: Rat BMSCs were transfected with adenoviruses harboring the human (h) LEP gene...
April 25, 2017: Journal of Periodontology
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